Ozonoterapia

Terapia realizada con gas Ozono que es generado  a partir de Oxigeno médico (pureza  99,9% ), en concentraciones programables.  Ya sea como tratamiento único o como terapia complementaria . Las dosis son acumulativas y sus efectos perduran en el tiempo. No tiene efectos secundarios y muy pocas contraindicaciones.

Efectos biológicos del ozono

Efectos biológicos del ozono

efectos-biologicos-del-ozonoCuando el ozono se introduce en el organismo, se disuelve rápidamente en el agua del plasma, o en los fluidos extracelulares o en la fina capa de agua que cubre la piel o en las mucosas del intestino, vagina, etc y reaccionando inmediatamente con diferentes biomoléculas generando un conjunto de mensajeros importantes (especies reactivas del oxigeno ERO y productos de oxidación lipídica POL, para luego desaparecer).

Inmediatamente y debido a su gran reactividad, el ozono reacciona con compuestos como antioxidantes, proteínas, carbohidratos y preferentemente los ácidos grasos poliinsaturados (AGPI), ácido ascórbico y úrico.

Se conoce que un exceso de radicales libres es dañino, sin embargo, el ozono induce un pequeño, controlado y transitorio estrés oxidativo, que lejos de producir daño, estimula los sistemas de defensa antioxidante, aspecto este que no debe ser confundido con el estrés continuado y progresivo (estrés crónico) que se mantiene en muchas patologías. Este efecto precondicionante del ozono es capaz de reequilibrar el estado redox alterado en el organismo por algún estímulo patológico.

sustancias-que-reaccionan-con-ozono

Otros de los efectos biológicos del ozono son:

  • mejora la circulación sanguínea y los procesos de oxigenación
  • modula el sistema inmunológico, regula el metabolismo
  • efecto germicida (bactericida, virucida, fungicida y antiparasitario)
  • interviene en la liberación de autacoides

Es importante recalcar que estas variadas acciones biológicas alcanzan resultados terapéuticos cuando el ozono es aplicado a dosis adecuadas y por una vía no dañina para el organismo. De este modo, no se producen reacciones adversas  ni daño genotóxico y el amplio espectro de efectos que genera, hace posible su aplicación en una gran diversidad de especialidades médicas y dentro de estas, en una disímil variedad de procesos patológicos.
Cerrar

Ventajas del tratamiento con ozono

¿Como actua?

  • Efectos del ozono sobre el metabolismo del oxígeno:

En los casos de alteración de la oxigenación pueden ser explicados los efectos del ozono, dado a sus acciones directas e indirectas, en las siguientes reacciones:

  1. Mediante un cambio en las propiedades reológicas de la sangre.
  2. Mediante un incremento en la velocidad de la glicólisis en el eritrocito.
  3. Mediante activación de la cadena respiratoria mitocondrial.
  • El ozono como modulador del estrés oxidativo:

Aunque la producción de especies reactivas del oxígeno tales como: radical hidroxilo, el anión superóxido y especies no radicálicas como el peróxido de hidrógeno, el ácido hipocloroso, son partes del metabolismo biológico normal y es además un fenómeno necesario para el adecuado funcionamiento de procesos vitales como es la fagocitosis, por otro lado, el incremento no controlado de estos productos están muy relacionados, así como el envejecimiento.

  • El ozono como agente modulador de la respuesta inmunitaria:

El ozono ha sido considerado como agente inductor ideal de citocinas, su eficacia inmunoduladora hacen posible su aplicación no solo en las deficiencias sino también en las enfermedades autoinmunes.

  • Efectos del ozono sobre la síntesis y/o liberación de autacoides:

La palabra autacoides deriva del griego ¨auto¨(propio) y del vocablo ¨akos¨ (agente medicinal o remedios) y se considera como tal aun grupo de sustancias endógenas con diversas acciones fisiológicas y farmacológicas las cuales participan en muchos eventos fisiológicos. Dos familias diferentes de autacoides derivados de los fosfolípidos de las membranas celulares han sido identificadas. Los eicosanoides, formados a partir de ciertos ácidos grasos polinsaturados (principalmente ácido araquidónico) donde se incluyen las prostanglandinas, prostaciclina, el tromboxano A2 y los leucotrienos, y otros fosfolípidos representados por el Factor Activador de Plaquetas.

  • Efecto del ozono como regulador metabólico:

En diferentes estudios realizados se ha constatado la acción reguladora del ozono en diferentes parámetros bioquímicos, tales como glicemia, colesterol, triglicéridos, creatinina, siendo normalizados  al concluir el ciclo y aquellos con valores normales se mantienen a lo largo del mismo. El ozono mediante mecanismos endógenos trata de normalizar el funcionamiento del organismo.

  • Efecto germicida del ozono:

El ozono es reconocido como un agente germicida poderoso contra virus, bacterias y hongos. Esta propiedad lo ha hecho útil en enfermedades infecciosas de variada etiología dado a su acción directa al microorganismo, así como por la respuesta inmunitaria que puede accionar.

  • Efecto del ozono sobre la activación plaquetaria:

En investigaciones realizadas (Matsuno K, 1997) encontraron que en el plasma rico en plaquetas (PRP)  y en la suspensión de plaquetas lavadas, tratadas con ozono, se observó la inhibición de la agregación plaquetaria, al parecer el ozono inhibió el aumento  de la concentración  de calcio inducida por colágeno y la trombina, inhibiendo a su vez  la señal de transducción entre el inductor y la activación plaquetaria.

Cerrar

Las aplicaciones clínicas de la ozonoterapia

Las aplicaciones clínicas de la ozonoterapia

Los resultados clínicos disponibles hasta ahora han demostrando que la ozonoterapia es a menudo tan útil o más que los tratamientos usuales en enfermedades tales como:

  • Osteomielitis
  • Empiema pleural
  • Abscesos con fístulas
  • Heridas infectadas
  • Úlceras por presión
  • Úlceras crónicas
  • Pie diabético
  • Quemaduras

(Payr, 1935; Aubourg, 1940; Rokitansky, 1982; Miroshin and Kontorshikova, 1995; Werkmeister, 1995; Shaschova et al., 1995; Filippi and Kirschner, 1995; Wasser, 1995a; Bulinin et al., 1995; Kudravcev et al., 1995; Kasumjan et al., 1995; Steinhart et al., 1999; Valacchi et al., 2005; Travagli et al., 2009a; Menendez et al., 2010).

Enfermedades isquémicas avanzadas (isquemia de las extremidades inferiores y del corazón, secuelas de accidentes vasculares encefálicos y cardiacos, posiblemente también ataque cardíaco, cuando los pacientes llegan demasiado tarde para la trombólisis) (Rokitansky, 1981, 1982; Romero et al., 1988; Amato, 2000; Giunta et al., 2001;Tylicki et al., 2001, 2003, 2004a, b; Biedunkiewicz et al., 2004; Di Paolo et al., 2005; Clavo et al., 2011).

Degeneración macular senil (forma atrófica),  porque la oftalmología  aún no tiene un tratamiento significativo (Riva Sanseverino et al., 1990; Bocci, 2002; Borrelli and Bocci, 2013).

Enfermedades neuro-degenerativas, tales como:

  • disfunciones del nervio óptico
  • retinitis pigmentosa
  • glaucoma primario de ángulo abierto
  • demencias seniles, incluyendo Alzheimer
  • enfermedad isquémica cerebrovascular
  • síndrome cócleo-vestibular
  • etc.

(Rodríguez, García, et al. 1998; Rodríguez, Menéndez, Devesa, et al. 1998; Rodríguez, Menéndez, García, et al. 1998; Copello et al., 2003; Copello et al., 2013).

Enfermedades ortopédicas degenerativas e inflamatorias (osteoartrosis,, etc)

(Riva Sanseverino, 1989; Verga, 1989; Siemsen, 1995; Bocci et al., 2000; Jucopilla et al., 2000; Alexandre et al., 2000, 2002; Bonetti et al., 2001; Fabris et al., 2001; Petralia et al., 2001; Tabaracci, 2001; Andreula et al., 2003).

 Síndrome de fatiga crónica y fibromialgia

(Cosentino et al., 2000; Loconte, 2000; Borrelli and Bocci, 2002; Hidalgo-Tallón et al., 2012).

Estomatología:

Lesiones de las raíces dentales por caries, especialmente en niños (Baysan et al., 2000).

Infecciones crónicas y recurrentes en la cavidad oral (Lynch, 2004).

Enfermedades agudas y crónicas infecciosas,

especialmente las que implican bacterias, virus y hongos, quimio y antibióticorresistentes (hepatitis, VIH-SIDA, infecciones herpéticas y herpes zoster, infecciones por papillomavirus, onicomicosis, candidiasis, giardiasis y criptosporidiosis) – la ozonoterapia parece un apoyo útil (Mattassi et al., 1985; Bocci and Paulesu, 1990; Konrad, 1995, 2001; Bocci et al., 1998c; Amato et al., 2000; Mawsouf et al., 2004; Bocci et al., 2009b).

En la fatiga por cáncer y la tolerancia a los quimioterápicos, la ozonoterapia, asociada con tratamientos habituales ha demostrado (Clavo, 2004b) su utilidad al mejorar la calidad de vida y disminuir los efectos adversos asociados a la quimio y la radioterapia.

 Enfermedades autoimmunes (enfermedades reumáticas, psoriasis, Crohn, etc)

(Menéndez et al., 1989; D’Ambrosi, 2002b; Esperanza, S., Ortellado, M., 2011; Molinari et al., 2014).

Demencia senil (Rodríguez et al., 1998).

Enfermedades pulmonares (enfisema, asma, enfermedad pulmonar obstructiva crónica, fibrosis pulmonar idiopática y síndrome agudo de dificultad respiratoria)

(Hernandez et al.,2005; Bocci, 2007b).

Enfermedades cutáneas (psoriasis, síndrome de Stevens-Johnson y dermatitis atópica)

(Abeck and Plötz, 2008; Borrelli et al., 2008; Izzo, 2008; Menendez et al., 2010; Sirito, 2006; Travagli et al., 2009a, b, 2010c; Zamora et al., 2008, Re et al., 2015).

Cáncer metastásico (Akbarov et al., 2010).

Sepsis severa y disfunción múltiple de órganos (Bocci and Brito, 2006).

Cerrar

Contraindicaciones

Contraindicaciones de la ozonoterapia.

  • Favismo mayor: Pacientes que sufren de un déficit significativo de la glucosa 6 fosfato deshidrogenasa
  • Embarazo: No estudiado en mujeres embarazadas. En estudios teratogénicos realizados en animales, no se han observado anomalías.

 Precauciones:

En algunas situaciones anormales (descompensación) en pacientes con hipertiroidismo y trombocitopenia.

Inestabilidad cardiovascular severa, (infarto del miocardio reciente).

Status convulsivos.

Cuadros hemorrágicos.

Reacciones adversas. «La ozonoterapia si se aplica respetando reglas sencillas, no tiene efectos colaterales y tiene muy pocas contraindicaciones».Numerosos experimentos clínicos indican que las reacciones adversas a los tratamientos con la mezcla ozono/oxígeno son raros y en la mayoría de las oportunidades están relacionados con errores en la técnica de suministración.

El Ozono no es un fármaco y como tal no provoca efectos colaterales, no desarrolla trastornos alérgicos y en general no se han descrito interacciones con los otros fármacos.Solo en casos excepcionales el estímulo doloroso inducido por la punción de la aguja, o la percepción por el paciente de su propia sangre, puede inducir en el paciente una crisis vagal (bradicardia, baja presión y sudoración) que en general es transitoria y no necesita tratamiento farmacológico.

Por otro lado la ozonoterapia obtiene también efectos secundarios positivos generales: aproximadamente 3/4 de los pacientes, particularmente aquellos que se sienten depresivos y asténicos, informan de una sensación de bienestar y euforia tras unos tratamientos, así como refieren un sueño más reparador; también se observa, generalmente a partir de cierta edad, aumento de la capacidad física, disminución del stress, mejora del apetito, etc.

Cerrar

Vías de administración

Vías de administración:

Ozonoterapia sistémica:

  • Ozonoterapia  Sistémica  Venosa:Se extrae sangre en cantidad ajustada al peso del paciente,  en un circuito cerrado, homologado por la agencia europea del medicamento, estéril  y con anticoagulante.  Se pone en contacto con una cantidad de ozono médico determinada por el Facultativo.  Una vez mezclada, estabilizada y utilizando la misma vía, se reinfunde al paciente.
  • Ozonoterapia Rectal:Mediante una sonda de tamaño y longitud adecuada al paciente,  se insufla con una jeringa, una mezcla de oxigeno y ozono en el recto,  con una concentración, volumen y frecuencia indicado por el médico.

Ozonoterapia tópica:

  • Local (bolsa o campana):Se coloca un dispositivo de aislamiento de la lesión/lesiones (bolsa o campana), en la zona afectada:  herida, úlcera, quemadura.   Se crea vacío y se establece un flujo de ozono a una concentración y tiempo determinado. La cantidad, número de sesiones y tipo de aplicación son decididas por el médico, en función del paciente y puede modificarlas según la respuesta al tratamiento.
  • Paravertebral:Se inyecta en la musculatura paravertebral  y/o  cerca de la lesión, una mezcla de oxigeno con gas ozono. La técnica se puede realizar con anestesia local.  La concentración de ozono, número de sesiones y tipo de infiltración son decididas por el médico,  en función del caso concreto del paciente y de la respuesta del mismo al tratamiento.
  • Infiltración:Se inyecta en la lesión una mezcla de oxigeno con gas ozono. Se puede realizar con anestesia local. La concentración de ozono, número de sesiones y tipo de infiltración son decididas por el médico,  en función del caso concreto del paciente y de la respuesta del mismo al tratamiento.
  • Intravaginal:Mediante una sonda,  se insufla con una jeringa ,una mezcla de oxigeno y ozono en la vagina con una concentración, volumen, frecuencia y número de sesiones  indicado por el médico.
  • Subcutanea:Se inyecta en la (hipodermis) una mezcla de oxigeno con gas ozono. La concentración de ozono, y número de sesiones, se realizaran en función del caso concreto del paciente y de la respuesta del mismo al tratamiento.

Cerrar

Historia

Historia:

Por el Dr. Saul Pressman, DCH LTOH c.

El ozono en la naturaleza

En la naturaleza, hay un ciclo de oxígeno al igual que hay un ciclo de agua.El oxígeno es liberado de las plantas terrestres y el plancton en el mar durante la fotosíntesis. El oxígeno es más ligero que el aire y flota hacia arriba en la atmósfera. El ozono esta presente de forma natural en pequeñas proporciones prácticamente en toda la atmósfera particularmente en la estratosfera a una distancia de 20 a 30 km sobre la superficie de la tierra. Una fuerte radiación ultravioleta en la longitud de onda de 185 a 200 nanómetros bombardea el oxígeno y se convierte una parte en ozono. El ozono creado existe como una fina capa en la atmósfera y que bloquea la pequeña porción del espectro UV que absorbe. La gran mayoría de la UV llega a la tierra lo que permite el bronceado.

El ozono también es creado por un rayo, y la cantidad producida en una tormenta promedio es a menudo el triple del límite permisible de 0.015 PPM según lo establecido por la EPA de Estados Unidos. Este ozono es lo que da el aire el maravilloso olor fresco después de una lluvia. El ozono también es creado por cascadas y olas rompiendo, lo que explica la sensación de energía y la calma experimentado cerca de estos sitios. Otra manera de ozono que se produce es por fotones del sol que se rompe aparte de óxido nitroso, un contaminante formado por la combustión de hidrocarburos en el motor de combustión interna. Este ozono se puede acumular en la niebla con humo debido a los cambios de temperatura y es un irritante de los pulmones y los ojos.

Estas son las formas de ozono creados por procesos naturales en la atmósfera.

El ozono médico

1870: Los primeros generadores de ozono fueron desarrollados por Werner von Siemens en Alemania en 1857, y 1870 vio el primer informe sobre el ozono se utiliza terapéuticamente para purificar la sangre, por C. Prestamista en Alemania.
1881: Hay evidencia del uso del ozono como desinfectante a partir de 1881, mencionado por el Dr. Kellogg en su libro sobre la difteria.
1893: En octubre de 1893, la planta de tratamiento de aguas primera del mundo que utiliza el ozono se instaló en Ousbaden, Holanda, y hoy hay más de 3.000 municipios de todo el mundo que utilizan el ozono para limpiar el agua y las aguas residuales.
1885: En 1885, la Asociación Médica de la Florida publicó “El ozono” por el Dr. Charles J. Kenworth, MD, detallando el uso del ozono con fines terapéuticos.
1896: En septiembre de 1896, el genio de la electricidad Nikola Tesla patentó su primer generador de ozono, y en 1900, formó  la empresa de ozono Tesla. Tesla vende máquinas de ozono a los médicos para uso médico, lo mismo que estamos haciendo 100 años más tarde, con un diseño basado en una de sus máquinas desde la década de 1920. Hemos visto uno de estos viejos generadores de 75 años, y todavía funciona perfectamente. Tesla produce aceite de oliva ozonizado y lo vendio a los naturópatas, y lo siguen haciendo.
1898: En 1898, el Instituto para la terapia de oxígeno se inició en Berlín por Thauerkauf y Luth. Se inyecta ozono en los animales y el ozono unido a magnesio, produciendo Homozon.
A partir de 1898, el Dr. Benedict Lust, un médico alemán que ejerce en Nueva York, que fue el creador y fundador de la Naturopatía, escribió muchos artículos y libros sobre el ozono.
1902: En 1902, J. H. Clarke de “Un diccionario de la práctica Materia Medica”, Londres, describe el uso exitoso de agua ozonizada en el tratamiento de la anemia, el cáncer, la diabetes, la gripe, el envenenamiento por morfina, úlceras bucales, envenenamiento por estricnina y la tos ferina.
1911: En 1911, “Un Manual de Trabajo de corrientes de alta frecuencia” fue publicado por el Dr. Noble Eberhart, MD. El Dr. Eberhart fue jefe del Departamento de Terapéutica fisiológicos en la Universidad de Loyola. Se utiliza el ozono para el tratamiento de la tuberculosis, anemia, clorosis, zumbido de oídos, tos ferina, asma, bronquitis, fiebre del heno, el insomnio, la neumonía, la diabetes, la gota y la sífilis.
1913: En 1913, la Asociación Oriental para la terapia de oxígeno se formó por el Dr. Blass y algunos socios alemanes.
1915: Durante la Primera Guerra Mundial , se utilizó el ozono para el tratamiento de heridas, pie de trinchera, gangrena y los efectos del gas venenoso. El Dr. Albert Wolff de Berlín también utiliza el ozono para el cáncer de colon, cáncer de cuello uterino y las úlceras decúbito en 1915.
1920: En 1920, el Dr. Charles Neiswanger, MD, Presidente del Hospital de la Facultad de Medicina de Chicago publicó “Electro Terapéutica Práctica”. El capítulo 32 se titula “El ozono como agente terapéutico.”
1926: En 1926, el Dr. Otto Warburg del Instituto Kaiser en Berlín anunció que la causa del cáncer es la falta de oxígeno a nivel celular. Recibió el Premio Nobel de Medicina en 1931 y nuevamente en 1944, la única persona en recibir dos premios Nobel de Medicina. También fue nominado para un tercero.
1929: En 1929, un libro titulado “El ozono y su acción terapéutica” se publicó en los EE.UU. listado de 114 enfermedades y cómo tratarlas con ozono. Sus autores fueron los jefes de todos los hospitales estadounidenses principales.
1932: El dentista suizo E. A. Fisch fue el uso del ozono en odontología antes de 1932, y lo introdujo al cirujano alemán Erwin Payr que lo utilizó desde ese momento en adelante.
1933: En 1933, la American Medical Association, encabezada por el Dr. Morris Fishbein dedicó a destruir todos los tratamientos médicos que estaban competitiva a la farmacoterapia. La supresión de la terapia de ozono comenzó entonces, y continúa todavía en algunos estados de los EE.UU.
1934: Aubourg y Lacoste eran médicos franceses que utilizan la insuflación de ozono a partir de 1934-1938.
1948: En 1948, el Dr. William Turska de Oregon comenzó a utilizar el ozono, el empleo de una máquina de su propio diseño, y en 1951, el Dr. Turska escribió el artículo “Oxidación”, que sigue siendo relevante hoy en día, y que se incluye en nuestro folleto. Dr. Turska fue pionera en la inyección de ozono en la vena porta, alcanzando de este modo el hígado.
1953: De 1953 en adelante, el médico alemán Hans Wolff utiliza ozono en su práctica, escribir el libro “Ozono Médico”, y la formación de muchos médicos en la terapia de ozono.
1957: En 1957, el Dr. J. Hansler patentó un generador de ozono que se ha formado la base de la expansión alemana de la ozonoterapia en los últimos 35 años.
1961: En 1961, Hans Wolff introdujo las técnicas de la autohemoterapia mayor y menor.
1977: En 1977, el Dr. Renate Viebahn proporciona una visión general técnica de la acción del ozono en el cuerpo.
1979: En 1979, el Dr. George Freibott comenzó a tratar a su primer paciente de SIDA con el ozono, y en 1980, el Dr. Horst Kief también informó éxito el tratamiento del SIDA con el ozono.
1987: En 1987, el Dr. Rilling y el Dr. Viebahn publicaron “El uso del ozono en la medicina,” el texto estándar sobre el tema.
1990: En 1990, los cubanos informaron de su éxito en el tratamiento del glaucoma, conjuntivitis y retinitis pigmentosa con ozono.
1992: En 1992, los rusos revelaron sus técnicas de uso del ozono burbujeado en salmuera para el tratamiento de las víctimas de quemaduras con resultados sorprendentes.

Hoy, después de 125 años de uso, la terapia de ozono es una modalidad reconocida en muchos países: Alemania, Francia, Italia, Rusia, Rumania, República Checa, Polonia, Hungría, Bulgaria, Israel, Cuba, Japón, México, y diez estados de Estados Unidos.
Cerrar

Bibliografía

Bibliografía:

Referencias de estudios científicos integradas en el Documento realizado por la World Federation of Ozone Therapy – WFOT

Revisión WFOT sobre Ozonoterapia Basada en Evidencias, 2015

  1. Abe, H., Ikebuchi, K., Shimbo, M., and Sekiguchi, S., 1998, Hypotensive reactions with a white cell-reduction filter: activation of kallikrein-kinin cascade in a patient, Transfusion 38:411–412.
  2. Abeck, D., Plötz, S., 2008. [Colloidal silver and ozonized olive oil for atopic dermatitis?]. Med Monatsschr Pharm 31, 265–266.
  3. Abraham, N. G., Drummond, G. S., Lutton, J. D., and Kappas, A., 1996, The biological significance and physiological role of heme oxygenase, Cell. Physiol. Biochem. 6:129–168.
  4. Aejmelaeus, R. T., Holm, P., Kaukinen, U., Metsä-Ketelä, T. J. A., Laippala, P., Hervonen, A. L. J., and Alho, H. E. R., 1997, Age-related changes in the peroxyl radical scavenging capacity of human plasma, Free Radic. Biol. Med. 23:69–75.
  5. Age-Related Eye Disease Study Research Group, 2001, A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8, Arch. Ophthalmol. 119:1417–1436.
  6. Agostini, G., and Agostini, S., 1994, Contributo alla conoscenza e al trattamento della parmiculopatia edemato-fibro-sclerotica, in Proceedings: VII National Meeting of Ozonetherapy,Roma.
  7. Agus, D. B., Vera, J. C., and Golde, D. W., 1999, Stromal cell oxidation: a mechanism by which tumors obtain vitamin C, Cancer Res. 59:4555–4558. Ahlman, H., and Nilsson, O., 2001, The gut as the largest endocrine organ in the body, Ann. Oncol. 12:S63–S68.
  8. Aicher, A., Heeschen, C., Mildner-Rihm, C., Urbich, C., Ihling, C., Technau-Ihling, K., Zeiher, A.M., and Dimmeler, S., 2003, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells, Natl. Med. 9:1370–1376.
  9. Aird, W. C., 2003, The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome, Blood 101:3765–3777.
  10. Aitken, C., and Jeffries, D. J., 2001, Nosocomial spread of viral disease, Clin. Microbiol. Rev. 14:528–546.
  11. Akaike, T., Suga, M., and Maeda, H., 1998, Free radicals in viral pathogenesis: molecular mechanisms involving superoxide and NO, Proc. Soc. Exp. Biol. Med. 217:64–73.
  12. Akbarov, E.T., Navruzov, S.N., Abdujapparov, S.B., Islamov, H.D., 2010. 350 Target therapy and endoarterial chemotherapy with ozonotherapy in combined treatment of metastatic colorectal cancer. Eur J Cancer Suppl 8, 111. doi:10.1016/S1359-6349(10)72057-7
  13. Akdis, C. A., and Blaser, K., 2001, Mechanisms of interleukin-10-mediated immune suppression, Immunology 103:136.
  14. Akdis, C. A., Blesken, T., Akdis, M., Wüthrich, B., and Blaser, K., 1998, Role of interleukin 10 in specific immunotherapy, J. Clin. Invest. 102:98–106.
  15. Akey, D., and Walton, T. E., 1985, Liquid-phase study of ozone inactivation of Venezuelan Equine Encephalomyelitis virus, Appl. Environ. Microbiol. 50:882–886.
  16. Alary, J., Geuraud, F., and Cravedi, J. P., 2003, Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways, Mol. Aspects Med. 24:177–187.
  17. Al Dalain, S. M., Martinez, G., Candelario-Jalil, E., Menendez, S., Re, L., Giuliani, A., and Leon,
  18. O. S., 2001, Ozone treatment reduces markers of oxidative and endothelial damage in an experimental diabetes model in rats, Pharmacol. Res. 44:391–396.
  19. Aldini, G., Gamberoni, L., Orioli, M. et al., 2006, Mass spectrometric characterization of covalent modification of human serum albumin by 4-hydroxy-trans-2-nonenal, J. Mass Spectrom. 41:1149–1161.
  20. Aldini, G., Vistoli, G., Regazzoni, L., et al., 2008, Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species? Chem. Res. Toxicol. 21:824–835.
  21. Al Sa’doni, H., and Ferro, A., 2000, S-Nitrosothiols: a class of nitric oxide-donor drugs, Clin. Sci. (Colch.) 98:507–520.
  22. Alexander, H. R., Jr., 2003, Hyperthermia and its modern use in cancer treatment, Cancer 98: 219–221.
  23. Alexandre, A., and Fumo, G., 1998, Discolisi percutanea mediante O2 –O3 nell’ernia discale lombare, in Lombalgie e lombosciatalgie. Criteri di diagnosi e cura (F. Ceccherelli, and A. Ricciardi, Eds.), Edizioni Libreria Cortina, Torino, pp. 367–377.
  24. Alexandre, A., Buric, J., Corò, L., Rigobello, L., and Scopetta, S., 2000, Discolisi percutanea mediante O2 –O3 intradiscale, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, pp. 7–8.
  25. Alexandre, A., Buric, J., Paradiso, R., Salgado, H., Murga, M., Corò, L., Albarreal, A., Scopetta, S., Giocoli, H., and Marin, F., 2002, Intradiscal injection of O2 –O3 to treat lumbar disc herniations: results at five years, Riv. Ital. Di Ossigeno Ozonoterapia 1:165–169.
  26. Alexandre, A., Pentimalli, L., Rigobello, L., and Corò, N., 1999, Amaurosi fugax in un caso di discolisi cervicale mediante O2 –O3 . in L’Ozonoterapia nel 2000 (F. Ceccherelli, and F. Giron, Eds.), Edizioni Libreria Cortina, Torino, pp.141–144.
  27. Allain, T. J., Bearn, J. A., Coskeran, P., Jones, J., Checkley, A., Butler, J., Wessely, S., and Miell, J. P., 1997, Changes in growth hormone, insulin, insulinlike growth factors (IGFs), and IGFbinding protein-1 in chronic fatigue syndrome, Biol. Psychiatry 41:567–573.
  28. Amato, G., 2000, Uso dell’ozonoterapia mediante grande autoemotrasfusione nella terapia dell’angina abdominis, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 Novembre 2000, p. 10.
  29. Amato, G., Sacchetta, A., Borrelli, E., and Bocci, V., 2000, Ruolo dell’ozonoterapia mediante grande autoemotrasfusione nel trattamento delle epatiti croniche post-epatite virale (II parte), in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, p. 11.
  30. American Diabetes Association, 2007, Standards of medical care in diabetes – 2007, Diabetes Care 30:S4–S41.
  31. Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A. J., Shen, X. D., Zhao, D., Zaky, J., Melinek, J., Lassman, C. R., Kolls, J. K., Alam, J., Ritter, T., Volk, H. D., Farmer, D. G., Ghobrial, R. M., Busuttil, R. W., and Kupiec-Weglinski, J. W., 1999, Upregulation of heme oxygenase1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury, J. Clin. Invest. 104:1631–1639.
  32. Ames, B. N., 2004, A role for supplements in optimizing health: the metabolic tune-up, Arch. Biochem. Biophys. 423:227–234.
  33. Ames, B. N., Shigenaga, M. K., and Hagen, T. M., 1993, Oxidants, antioxidants, and the degenerative diseases of aging, Proc. Natl. Acad. Sci. USA 90:7915–7922.
  34. Anderson, C., 1992, Gene therapy researcher under fire over controversial cancer trials, Nature 360:399–400.
  35. Anderson, M. M., Hazen, S. L., Hsu, F. F., and Heinecke, J. W., 1997, Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxyamino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein, J. Clin. Invest. 99: 424–432.
  36. Andreula, C. F., Simonetti, L., De Santis, F., Agati, R., Ricci, R., and Leonardi, M., 2003, Minimally invasive oxygen-ozone therapy for lumbar disk herniation, AJNR Am. J. Neuroradiol. 24:996–1000.
  37. Angelucci, E., Brittenham, G. M., McLaren, C. E., Ripalti, M., Baronciani, D., Giardini, C., Galimberti, M., Polchi, P., and Lucarelli, G., 2000, Hepatic iron concentration and total body iron stores in thalassemia major, N. Engl. J. Med. 343:327–331.
  38. Angelucci, E., Muretto, P., Lucarelli, G., Ripalti, M., Baronciani, D., Erer, B., Galimberti, M., Giardini, C., Gaziev, D., and Polchi, P., 1997, Phlebotomy to reduce iron overload in patients cured of thalassemia by bone marrow transplantation. Italian Cooperative Group for Phlebotomy Treatment of Transplanted Thalassemia Patients, Blood 90:994–998.
  39. Antonelli, G., Bagnato, F., Pozzilli, C., Simeoni, E., Bastianelli, S., Currenti, M., De Pisa, F., Fieschi, C., Gasperini, C., Salvetti, M., and Dianzani, F., 1998, Development of neutralizing antibodies in patients with relapsing-remitting multiple sclerosis treated with IFN-beta1a, J. Interferon Cytokine Res. 18:345–350.
  40. Antunes, F., and Cadenas, E., 2000, Estimation of hydrogen peroxide gradient across biomembranes, FEBS Lett. 475:121–126.
  41. Ardizzone, S., and Bianchi Porro, G., 2002, Inflammatory bowel disease: new insights into pathogenesis and treatment, J. Intern. Med. 252:475–496.
  42. Argiles, J. M., Moore-Carrasco, R., Fuster, G., Busquets, S., and Lopez-Soriano, F. J., 2003, Cancer cachexia: the molecular mechanisms, Int. J. Biochem. Cell Biol. 35:405–409.
  43. Aris, R. M., Christian, D., Hearne, P. Q., Kerr, K., Finkbeiner, W. E., and Balmes, J. R., 1993, Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy, Am. Rev. Respir. Dis. 148:1363–1372.
  44. Arnason, B. G. W., 1993, Interferon beta in multiple sclerosis, Neurology 43:641–643.
  45. Arvin, A. M., and Prober, C. G., 1997, Herpes simplex virus type 2 – a persistent problem, N. Engl. J. Med. 337:1158–1159.
  46. Aslan, M., Ryan, T. M., Adler, B., Townes, T. M., Parks, D. A., Thompson, J. A., Tousson, A., Gladwin, M. T., Patel, R. P., Tarpey, M. M., Batinic-Haberle, I., White, C. R., and Freeman, B. A., 2001, Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease, Proc. Natl. Acad. Sci. USA 98:15215–15220.
  47. Aslan, M., Freeman, B. A., 2007, Redox-dependent impairment of vascular function in sickle cell disease. Free Radic. Biol. Med. 43:1469–1483.
  48. Asplund, K., 2002, Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review, J. Intern. Med. 251:372–392.
  49. Atherton, D. J., 2003, Topical corticosteroids in atopic dermatitis, BMJ 327:942–943.
  50. Aubourg, P., 1936, Colibacillose aigue, colibacillose cronique: ameliorations cliniques notables par un traitement d’ozone, Bull. Med. Paris 140:644–654.
  51. Aubourg, P., 1940, Ozon in der Chirurgie, Mem. Acad. Chir. 65:1183–1192.
  52. Ault, J. G., and Lawrence, D. A., 2003, Glutathione distribution in normal and oxidatively stressed cells, Exp. Cell Res. 285:9–14.
  53. Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., and Karin, M., 1995, Immunosuppression by glucocorticoids: inhibition of NF-k B activity through induction of IkB synthesis, Science 270:286–290.
  54. Awasthi., Y. C., Ansari, G. A., and Awasthi, S., 2005, Regulation of 4-hydroxynonenal mediated signalling by gluthatione S-transferase, Methods Enzymol. 401:379–407.
  55. Ayres, R. M., Stott, R., Mara, D. D., and Lee, D. L., 1992, Wastewater reuse in agriculture and the risk of intestinal nematode infection, Parasitol. Today 8:32–35.
  56. Babior, B. M., 1978, Oxygen-dependent microbial killing by phagocytes (1st and 2nd part), N. Engl. J. Med. 298:659–668.
  57. Babior, B. M., 2000, Phagocytes and oxidative stress, Am. J. Med. 109:33–44.
  58. Babior, B. M., Takeuchi, C., Ruedi, J., Gutierrez, A., and Wentworth, P., Jr., 2003, Investigating antibody-catalyzed ozone generation by human neutrophils, Proc. Natl. Acad. Sci. USA 100:3031–3034.
  59. Back, T., 1998, Pathophysiology of the ischemic penumbra – revision of a concept, Cell Mol. Neurobiol. 18:621–638.
  60. Badwey, J. A., and Karnovsky, M. L., 1980, Active oxygen species and the functions of phagocytic leukocytes, Annu. Rev. Biochem. 49:695–726.
  61. Baert, F., Noman, M., Vermeire, S., Van Assche, G., D’Haens, G., Carbonez, A., and Rutgeerts, P., 2003, Influence of immunogenicity on the long-term efficacy of infliximab in Crohn’s disease, N. Engl. J. Med. 348:601–608.
  62. Baeuerle, P. A., and Henkel, T., 1994, Function and activation of NF-kB in the immune system, Annu. Rev. Immunol. 12:141–179.
  63. Bailar, J. C., III, and Gornik, H. L., 1997, Cancer undefeated, N. Engl. J. Med. 336:1569–1574.
  64. Bak, I., Papp, G., Turoczi, T., Varga, E., Szendrei, L., Vecsernyes, M., Joo, F., and Tosaki, A., 2002, The role of heme oxygenase-related carbon monoxide and ventricular fibrillation in ischemic/reperfused hearts, Free Radic. Biol. Med. 33:639–648.
  65. Baker, K. H., Hegarty, J. P., Redmond, B., Reed, N. A., and Herson, D. S., 2002, Effect of oxidizing disinfectants (chlorine, monochloramine, and ozone) on Helicobacter pylori, Appl. Environ. Microbiol. 68:981–984.
  66. Barakat, S., Seif-El Nasr, A., Ardel-Maksoud, N., El-Ebiary, F., Amer, H., Zaghloul, A., and Thabet, S., 2004, Induktion der angiogenese durch medizinisches ozon, in Ozon-Handbuch Grundlagen Pravention Therapie (R. Viebahn-Hansler, and H. G. Knoch, Eds.), Ecomed, Landsberg: in press.
  67. Barber, E., Menéndez, S., León, O. S., Barber, M. O., Merino, N., Calunga, J. L., Cruz, E., and Bocci, V., 1999, Prevention of renal injury after induction of ozone tolerance in rats submitted to warm ischaemia, Mediators Inflamm. 8:37–41.
  68. Barnes, P. J., 2000, Chronic obstructive pulmonary disease, N. Engl. J. Med. 343:269–280.
  69. Barnes, P. J., 2009a, Histone deacetylase-2 and airway disease, Ther. Adv. Respir. Dis. 3(5): 235–243.
  70. Barnes, P. J., 2009b, The cytokine network in COPD, Am. J. Respir. Cell Mol. Biol. 41:631–638.
  71. Barnes, P. J., and Karin, M., 1997, Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases, N. Engl. J. Med. 336:1066–1071.
  72. Barnes, P. J., and Liew, F. Y., 1995, Nitric oxide and asthmatic inflammation, Immunol. Today 16:128–130.
  73. Barzilai, N., and Bartke, A., 2009, Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones, J. Gerontol. A Biol. Sci. Med. Sci. 64:187–191.
  74. Basu, S., 2004, Isoprostanes: novel bioactive products of lipid peroxidation, Free Radic. Res. 38:105–122.
  75. Baulieu, E.-E., and Robel, P., 1998, Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids, Proc. Natl. Acad. Sci. USA 95:4089–4091.
  76. Baykal, Y., Yilmaz, M. I., Celik, T., Gok, F., Rehber, H., Akay, C., and Kocar, I. H., 2003, Effects of antihypertensive agents, alpha receptor blockers, beta blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and calcium channel blockers, on oxidative stress, J. Hypertens. 21:1207–1211.
  77. Baynes, J. W., 1991, Role of oxidative stress in development of complications in diabetes, Diabetes 40:405–412.
  78. Baysan, A., Whiley, R. A., and Lynch, E., 2000, Antimicrobial effect of a novel ozone-generating device on micro-organisms associated with primary root carious lesions in vitro, Caries Res. 34:498–501.
  79. Beal, M. F., 2002, Oxidatively modified proteins in aging and disease, Free Radic. Biol. Med. 32:797–803.
  80. Beaglehole, R., and Bonita, R., 2009, Alcohol: a global health priority, Lancet 373:2173–2174.
  81. Beck, L. S., DeGuzman, L., Lee, W. P., Xu, Y., Siegel, M. W., and Amento, E. P., 1993, One systemic administration of transforming growth factor- b1 reverses age- or glucocorticoidimpaired wound healing, J. Clin. Invest. 92:2841–2849.
  82. Beckman, K. B., and Ames, B. N., 1998, The free radical theory of aging matures, Physiol. Rev. 78:547–581.
  83. Belianin, Il., Abdullah, R. Iu., 2000, Use of soluble ozone in combined treatment of pulmonary tuberculosis: lipid peroxidation and blood antioxidative defense system. Probl. Tuberk 3: 41–44.
  84. Bell, D. S., 2004a, Type 2 diabetes mellitus: what is the optimal treatment regimen? Am. J. Med. 116(suppl 5A):23S–29S.
  85. Bell, D. S., 2004b, Advantages of a third-generation beta-blocker in patients with diabetes mellitus, Am. J. Cardiol. 93:49B–52B.
  86. Bell, S., and Kamm, M. A., 2000, Antibodies to tumour necrosis factor alpha as treatment for Crohn’s disease, Lancet 355:858–860.
  87. Bell, M. L., Dominici, F., and Samet, J. M., 2005, A meta-analysis of time-series studies of ozone and mortality with comparison to the national morbidity, mortality and air pollution study, Epidemiology 16:436–445.
  88. Belluzzi, A., Brignola, C., Campieri, M., Pera, A., Boschi, S., and Miglioli, M., 1996, Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease, N. Engl. J. Med. 334: 1557–1560.
  89. Beltrani, V. S., 1999, The clinical spectrum of atopic dermatitis, J. Allergy Clin. Immunol. 104: S87–S98.
  90. Bender, D. A., 2002, Daily doses of multivitamin tablets, BMJ 325:173–174.
  91. Bennett, S. P., Griffiths, G. D., Schor, A. M., Leese, G. P., and Schor, S. L., 2003, Growth factors in the treatment of diabetic foot ulcers, Br. J. Surg. 90:133–146.
  92. Benson, H., and Friedman, R., 1996, Harnessing the power of the placebo effect and renaming it “remembered wellness”, Annu. Rev. Med. 47:193–199.
  93. Bergamini, A., Capozzi, M., Ghibelli, L., Dini, L., Salanitro, A., Milanese, G., Wagner, T., Beninati, S., Delfina Pesce, C., Amici, C., and Rocchi, G., 1994, Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells, J. Clin. Invest. 93:2251– 2257.
  94. Bergers G., Hanahan, D., 2008, Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 8:592–603.
  95. Bergo, G. W., and Tyssebotn, I., 1999, Cardiovascular effects of hyperbaric oxygen with and without addition of carbon dioxide, Eur. J. Appl. Physiol. Occup. Physiol. 80: 264–275.
  96. Bergofsky, E. H., and Bertun, P., 1966, Response of regional circulations to hyperoxia, J. Appl. Physiol. 21:567–572.
  97. Bergqvist, D., 1999, Salvage of critically ischaemic limbs, Lancet 354:1920–1921.
  98. Bernier, J., Denekamp, J., Rojas, A., Minatel, E., Horiot, J., Hamers, H., Antognoni, P., Dahl, O., Richaud, P., van Glabbeke, M., and Pi inverted question m., M., 2000, ARCON: accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the Co-operative group of radiotherapy of the european organization for research and treatment of cancer (EORTC), Radiother. Oncol. 55:111–119.
  99. Berson, E. L., Remulla, J. F. C., Rosner, B., Sandberg, M. A., and Weigel-DiFranco, C., 1996, Evaluation of patients with retinitis pigmentosa receiving electric stimulation, ozonated blood, and ocular surgery in Cuba, Arch. Ophthalmol. 114:560–563.
  100. Bertoletti, A., and Izzo, A., 2006, Oxygen-ozone treatment of Buruli ulcer, Riv. Ital. Ossigeno Ozonoterapia 5:129–134.
  101. Bevers, R. F. M., Bakker, D. J., and Kurth, K. H., 1995, Hyperbaric oxygen treatment for haemorrhagic radiation cystitis, Lancet 346:803–805.
  102. Beyerle, 1996, cited by Null, 1996 (Ozone: a wide-spectrum realer, Penthouse Magazine January). Biedunkiewicz, B., Tylicki, L., Nieweglowski, T., Burakowski, S., and Rutkowski, B., 2004, Clinical efficacy of ozonated autohemotherapy in hemodialyzed patients with intermittent claudication: an oxygen-controlled study, Int. J. Artif. Organs 27:29–34.
  103. Bilger, B., 1995, Forever young, Sciences September/October:26–30.
  104. Bishop, G. A., Ramirez, L. M., Baccam, M., Busch, L. K., Pederson, L. K., and Tomai, M. A., 2001, The immune response modifier resiquimod mimics CD40-induced B cell activation, Cell Immunol. 208:9–17.
  105. Block, J. A., and Sequeira, W., 2001, Raynaud’s phenomenon, Lancet 357:2042–2048.
  106. Bloomer RJ, Kabir MM, Marshall KE, Canale RE, Farney TM, 2010, Postprandial oxidative stress in response to dextrose and lipid meals of differring. Lipid Health Disease 9:79
  107. Bocchi, L., Cervelli, C., and Ferrata, P., 1998, La nucleoaspirazione. in Lombalgie e lombosciatalgie. Criteri di diagnosi e cura (F. Ceccherelli, and A. Ricciardi, Eds.), Edizioni Libreria Cortina, Torino, pp. 285–293.
  108. Bocchi, L., Cervelli, C., and Ferrata, P., 2000, L’ossigeno-ozono terapia nel trattamento delle patologie vertebrali lombari, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, p. 15.
  109. Bocci, V., 1981a, Determinants of erythrocyte ageing: a reappraisal, Br. J. Haematol. 48:515– 522.
  110. Bocci, V., 1981b, Pharmacokinetic studies of interferons, Pharmacol. Ther. 13(3):421–440.
  111. Bocci, V., 1981c, Production and role of interferon in physiological conditions, Biol. Rev. 56: 49– 85.
  112. Bocci, V., 1985a, Immunomodulators as local hormones: new insights regarding their clinical utilization., J. Biol. Resp. Modif. 4:340–352.
  113. Bocci, V., 1985b, Administration of interferon at night may increase its therapeutic index, Cancer Drug Del. 2:313–318.
  114. Bocci, V., 1987a, May hyperbaric oxigenation be useful to patients with AIDS? J. Biol. Regul. Homeost. Agents 1:201.
  115. Bocci, V., 1987b, Metabolism of protein anticancer agents. (Updated and reprinted in 1994 in Int. Encyclopedia of Pharmacology and Therapeutics, Sec.140 Anticancer Drugs, Oxford: Pergamon Press, pp. 387–436), Pharmacol. Ther. 34:1–49.
  116. Bocci, V., 1988a, Roles of interferon produced in physiological conditions. A speculative review, Immunology 64:1–9.
  117. Bocci, V., 1988b, Central nervous system toxicity of interferons and other cytokines, J. Biol. Regul. Homeost. Agents 2:107–118.
  118. Bocci, V., 1988c, Roles of interferon produced in physiological conditions. A speculative review, Immunology 64:1–9.
  119. Bocci, V., 1990a, Catabolism of therapeutic proteins and peptides with implications for drug delivery., Adv. Drug Deliv. Rev. 4:149–169.
  120. Bocci, V., 1990b, Tumor therapy with biological response modifiers. Why is progress slow? EOS-J. Immunol. Immunopharmacol. 10:79–82.
  121. Bocci, V., 1991a, Absorption of cytokines via oropharyngeal-associated lymphoid tissues. Does an unorthodox route improve the therapeutic index of interferon? Clin. Pharmacokinet. 21: 411– 417.
  122. Bocci, V., 1991b, Interleukins. Clinical pharmacokinetics and practical implications, Clin. Pharmacokinet. 21:274–284.
  123. Bocci, V., 1992a, Ozonization of blood for the therapy of viral diseases and immunodeficiencies. A hypothesis, Med. Hypotheses 39:30–34.
  124. Bocci, V., 1992b, Physicochemical and biologic properties of interferons and their potential uses in drug delivery systems, Crit. Rev. Ther. Drug Carr. Syst. 9:91–133.
  125. Bocci, V., 1992c, The neglected organ: bacterial flora has a crucial immunostimulatory role, Perspect. Biol. Med. 35:251–260.
  126. Bocci, V., 1993a, Interferon. Una storia recente ed antichissima. Fisiopatologia e clinica del sistema interferon, Antea Edizioni, pp. 1–205.
  127. Bocci, V., 1993b, Mistletoe (viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy. A review, J. Biol. Regul. Homeost. Agents 7:1–6.
  128. Bocci, V., 1994a, A reasonable approach for the treatment of HIV infection in the early phase with ozonetherapy (autohemotherapy). How inflammatory cytokines may have a therapeutic role, Mediators Inflamm. 3:315–321.
  129. Bocci, V., 1994b, Autohaemotherapy after treatment of blood with ozone. A reappraisal, J. Int. Med. Res. 22:131–144.
  130. Bocci, V., 1996a, Does ozone therapy normalize the cellular redox balance? Med. Hypotheses 46:150–154.
  131. Bocci, V., 1996b, Ozone as a bioregulator. Pharmacology and toxicology of ozonetherapy today, J. Biol. Regul. Homeost. Agents 10:31–53.
  132. Bocci, V., 1996c, Ozone: a mixed blessing. New mechanisms of the action of ozone on blood cells make ozonated major autohaemotherapy (MAH) a rational approach, Forsch. Komplementärmed. 3:25–33.
  133. Bocci, V., 1998a, Ipotetici meccanismi di azione dell’ozono nel trattamento del conflitto discoradicolare, in Lombalgie e lombosciatalgie. Criteri di diagnosi e cura (F. Ceccherelli, and A. Ricciardi, Eds.), Edizioni Libreria Cortina, Torino, pp. 331–340.
  134. Bocci, V., 1998b, Is ozonetherapy therapeutic? Perspect. Biol. Med. 42:131–143.
  135. Bocci, V., 1998c, Ozonetherapy as a possible biological response modifier in cancer, Forsch. Komplementärmed. 5:54–60.
  136. Bocci, V., 1999a, Biological and clinical effects of ozone. Has ozonetherapy a future in medicine? Br. J. Biomed. Sci. 56:270–279.
  137. Bocci, V., 1999b, Ozonetherapy as a complementary medical approach. Where are we and where do we need to go? in Proceedings of the International Ozone Symposium, 21 and 22 October 1999, Basel, Switzerland (IOA – EA3 G, Ed.), Bauer Druck AG, Basel, pp. 353–374.
  138. Bocci, V., 2000, Ossigeno-ozono terapia, Casa Editrice Ambrosiana, Milano, pp. 1–324.
  139. Bocci, V., 2002, Oxygen-ozone therapy, a critical evaluation, Kluwer Academic Publischer, Dordrecht.
  140. Bocci, V., 2004, Ozone as Janus: this controversial gas can be either toxic or medically useful, Mediators Inflamm. 13:3–11.
  141. Bocci, V., 2006a, Scientific and medical aspects of ozone therapy, state of the art, Arch. Med. Res. 37:425–435.
  142. Bocci, V., 2006b, Is it true that ozone is always toxic? The end of the dogma, Toxicol. Appl. Pharmacol. 216:493–504.
  143. Bocci, V., 2007a, Can ozonetherapy be performed if the biochemistry of the process cannot be controlled? Arch. Med. Res. 38:584–585.
  144. Bocci, V., 2007 Può l’Ossigeno-Ozonoterapia migliorare la prognosi della bronco-pneumopatia cronica ostruttiva? Giorn. Ital. Mal. Tor. 61:434–446.
  145. Bocci, V., 2008a, Why orthodox medicine has not yet taken advantage of ozone therapy, Arch. Med. Res. 39:259–260.
  146. Bocci, V., 2008b, The failure of the ACCLAIM trial is due to an irrational technology, Int. J. Cardiol. DOI: 10 1016/ijcrd.2008.10.001.
  147. Bocci, V., 2008c, Non-specific immunomodulation in chronic heart failure, Lancet 371(9630):2083.
  148. Bocci, V., 2008d, Does ozone really “cure” cancer? Int. J. Cancer 123(5):1222.
  149. Bocci, V., 2011, Ozone. A new medical drug. Springer Dordrecht Heidelberg London New York
  150. Bocci, V., Aldinucci, C., Borrelli, E., Corradeschi, F., Diadori, A., Fanetti, G., and Valacchi, G., 2001a, Ozone in medicine, Ozone Sci. Eng. 23:207–217.
  151. Bocci, V., Aldinucci, C., Mosci, C., Carraro, F., and Valacchi, F., 2007a, Ozonation of human blood induces a remarkable upregulation of Heme Oxygenase-1, Mediators Inflamm. 2007:26785, DOI: 10.1155/2007/26785.
  152. Bocci, V., Aldinucci, C., and Bianchi, L., 2005, The use of hydrogen peroxide as a medical drug, Riv. Ital. Ossigeno Ozonoterapia 4:30–39.
  153. Bocci, V., and Aldinucci, C., 2006, Biochemical modifications induced in human blood by oxygenation-ozonation, J. Biochem. Mol. Toxicol. 20:133–138.
  154. Bocci, V., Bianchi, L., Larin, A., 2003, The ozone enigma in medicine. The biochemical relationship between ozone and body fluids may account for its biological, therapeutic and toxic effects, Riv. Ital. Ossigeno Ozonoterapia 2:130-120.
  155. Bocci, V., and Brito, G. S., 2006, Ozone therapy in critical patients. Rationale of the therapy and proposed guidelines, Riv. Ital. Ossigeno Ozonoterapia 5:7–11.
  156. Bocci, V., and Di Paolo, N., 2004, Oxygenation-ozonization of blood during extracorporeal circulation (EBOO). Part III: a new medical approach, Ozone Sci. Eng. 26:195–205.
  157. Bocci, V., Di Paolo, N., 2009, Oxygen-ozone therapy in medicine: an update. Blood Purif. 28: 373–376.
  158. Bocci, V., and Paulesu, L., 1990, Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes, Haematologica 75:510–515.
  159. Bocci, V., Borrelli, E., Corradeschi, F., and Valacchi, G., 2000, Systemic effects after colorectal insufflation of oxygen-ozone in rabbits, Int. J. Med. Biol. Environ. 28:109–113.
  160. Bocci, V., Borrelli, E., Travagli, V., and Zanardi, I., 2009a, The ozone paradox: ozone is a strong oxidant as well as a medical drug, Medic. Res. Rev. 29:646–682.
  161. Bocci, V., Borrelli, E., Valacchi, G., and Luzzi, E., 1999a, Quasi-total-body exposure to an oxygen-ozone mixture in a sauna cabin, Eur. J. Appl. Physiol. Occup. Physiol. 80:549–554.
  162. Bocci, V., Borrelli, E., Travagli, V., and Zanardi, I., 2008, The term “liquid polyatomic oxygen” requires a correction but chemo and radiotherapy combined with ozone therapy may help cancer patients, Int. J. Ozone Ther. 7:63–65.
  163. Bocci, V., Carraro, F., Naldini, A., Paulesu, L., and Pessina, G. P., 1990, Roles of interferons in physiological conditions and for the control of viral diseases. in Microbiological, chemotherapeutical and immunological problems in high risk patients (E. Garaci, G. Renzini, F. Filadoro, A. L. Goldstein, and J. and Verhoef, Eds.), Serono Symposia Publication from Raven Press, New York, NY, pp. 243–250.
  164. Bocci, V., Di Paolo, N., Borrelli, E., Larini, A., and Cappelletti, F., 2001b, Ozonation of blood during extracorporeal circulation II. Comparative analysis of several oxygenators-ozonators and selection of one type, Int. J. Artif. Organs 24:890–897.
  165. Bocci, V., Di Paolo, N., Garosi, G., Aldinucci, C., Borrelli, E., Valacchi, G., Cappelli, F., Guerri, L., Gavioli, G., Corradeschi, F., Rossi, R., Giannerini, F., and Di Simplicio, P., 1999b, Ozonation of blood during extracorporeal circulation. I. Rationale, methodology and preliminary studies, Int. J. Artif. Organs 22:645–651.
  166. Bocci, V., and Di Paolo., N., 2009, Oxygen-ozone therapy in medicine: an update, Blood Purif. 28:373–376.
  167. Bocci, V., Larini, A., and Micheli, V., 2005, Restoration of normoxia by ozone therapy may control neoplastic growth: a review and a working hypothesis, J. Altern. Complement. Med. 11: 257–265.
  168. Bocci, V., Luzzi, E., Corradeschi, F., and Paulesu, L., 1994a, Studies on the biological effects of ozone: 5. Evaluation of immunological parameters and tolerability in normal volunteers receiving ambulatory autohaemotherapy, Biotherapy 7:83–90.
  169. Bocci, V., Luzzi, E., Corradeschi, F., and Silvestri, S., 1994b, Studies on the biological effects of ozone: 6. Production of transforming growth factor b1 by human blood after ozone treatment, J. Biol. Regul. Homeost. Agents 8:108–112.
  170. Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., and Di Stefano, A., 1993a, Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines, Lymphokine Cytokine Res. 12:121–126.
  171. Bocci, V., Luzzi, E., Corradeschi, F., Paulesu, L., Rossi, R., Cardaioli, E., and Di Simplicio, P., 1993b, Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes, J. Biol. Regul. Homeost. Agents 7:133–138.
  172. Bocci, V., Pessina, G. P., Paulesu, L., Muscettola, M., and Valeri, A., 1988, The lymphatic route. V. Distribution of human natural interferon-β in rabbit plasma and lymph, J. Interferon Res. 8:633–640.
  173. Bocci, V., Pogni, R., Corradeschi, F., Busi, E., Cervelli, C., Bocchi, L., and Basosi, R., 2001c, Oxygen-ozone in orthopaedics: EPR detection of hydroxyl free radicals in ozone-treated “nucleus pulposus” material, Riv. Neuroradiol. 14:55–59.
  174. Bocci, V., Russi, M., and Rita, G., 1967, Recovery and identification of interferon in the rabbit urine, Experientia 23:1–5.
  175. Bocci, V., Travagli, V., and Zanardi, I., 2009b, The failure of HIV vaccines: a new autovaccine may overcome some problems, Med. Hypothesis 72:662–664.
  176. Bocci, V., Travagli, V., and Zanardi, I., 2009d, May oxygen-ozone therapy improves cardiovascular disorders? Cardiovasc. Hematol. Disord. Drug Targets 9:78–85.
  177. Bocci, V., Travagli, V., and Zanardi, I., 2009e, Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss, J. Laryngol. Oto. 123(7):820.
  178. Bocci, V., Zanardi, I., and Travagli, V. 2010a, Ozonation of human HIV-infected plasmas for producing a global vaccine. How HIV-patients may help fighting the HIV pandemia. Virulence1:215–217.
  179. Bocci, V., Zanardi, I., Huijberts, M. S. P., Travagli, V., 2010c, Diabetes and chronic oxidative stress: a perspective based on the possible usefulness of ozone therapy. Diabetes Metab.
  180. Syndr. Clin. Res. Rev. doi: 10.1016/j.dsx.2010.05.014, in press.
  181. Bocci, V., Valacchi, G., Corradeschi, F., Aldinucci, C., Silvestri, S., Paccagnini, E., and Gerli, R., 1998a, Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone, J. Biol. Regul. Homeost. Agents 12:67–75.
  182. Bocci, V., Valacchi, G., Corradeschi, F., and Fanetti, G., 1998b, Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production, Mediators Inflamm. 7:313–317.
  183. Bocci, V., Valacchi, G., Rossi, R., Giustarini, D., Paccagnini, E., Pucci, A. M., and Di Simplicio, P., 1999c, Studies on the biological effects of ozone: 9. Effects of ozone on human platelets, Platelets 10:110–116.
  184. Bocci, V., Venturi, G., Catucci, M., Valensin, P. E., and Zazzi, M., 1998c, Lack of efficacy of ozone therapy in HIV infection, Clin. Microbiol. Infec. 4:667–669.
  185. Bocci, V., Zanardi, I., Travagli, V., and Di Paolo, N., 2007b, Oxygenation-ozonation of blood during extracorporeal circulation: in vitro efficiency of a new gas exchange device, Artif. Organs 31:743–748.
  186. Bocci, V., Zanardi, I., Travagli, V., 2010a, The irrationality of a non-specific immunomodulation therapy used in cardiovascular diseases deserves a critical comment. Atherosclerosis 211:38– 39.
  187. Bocci, V., Zanardi, I., Travagli, V., 2010b, Potentiality of oxygen-ozonetherapy to improve the health of aging people. Curr. Aging Sci. 3: in press Bentham Science Publisher.
  188. Bocci, V., Zanardi, I., Michaeli, D., and Travagli, V., 2009e, Mechanisms of action and chemicalbiological interactions between ozone and body compartments: a critical appraisal of the different administration routes, Curr. Drug Ther. 4:159–173.
  189. Bocci, V., Zanardi, I., Huijberts, M. S. P., and Travagli, V., 2010b, Diabetes and chronic oxidative stress: a hypothesis paper based on the possible usefulness of ozonetherapy. Diabetes Metab.Syndr. Clin. Res. Rev. doi: 10.1016/j.dsx.2010.05.014
  190. Bocci, V., Zanardi, I., Travagli, V., 2011, Ozone acting on human blood yields a hormetic doseresponse relationship. J. Trans. Med. 9:66
  191. Bodmar, A. G., Ouellette, M., Frolkis, M. et al., 1998, Extension of life-span by introduction of telomerase into normal human cells, Science 279:349–352.
  192. Boehm, T., Folkman, J., Browder, T., and O’Reilly, M. S., 1997, Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance, Nature 390:404–407.
  193. Bolton, A. E., 2005, Biologic effects and basic science of a novel immune-modulation therapy, Am. J. Cardio. 95:24C–29C.
  194. Bondy, S. C., 1995, The relation of oxidative stress and hyperexcitation to neurological disease, Proc. Soc. Exp. Biol. Med. 208:337–345.
  195. Boneschi, F. M., Rovaris, M., Johnson, K. P., Miller, A., Wolinsky, J. S., Ladkani, D., Shifroni, G., Comi, G., and Filippi, M., 2003, Effects of glatiramer acetate on relapse rate and accumulated disability in multiple sclerosis: meta-analysis of three double-blind, randomized, placebocontrolled clinical trials, Mult. Scler. 9:349–355.
  196. Bonetti, M., Cotticelli, B., Valdenassi, L., and Richelmi, P., 2001, Analisi dei risultati dopo trattamento con O2 –O3 nelle ernie intra ed extra foraminali lombari, Riv. Neuroradiol. 14:89–92.
  197. Boni, C., Bertoletti, A., Penna, A., Cavalli, A., Pilli, M., Urbani, S., Scognamiglio, P., Boehme, R.,
  198. Panebianco, R., Fiaccadori, F., and Ferrari, C., 1998, Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B, J. Clin. Invest. 102:968–975.
  199. Bonifati, C., and Ameglio, F., 1999, Cytokines in psoriasis, Int. J. Dermatol. 38:241–251.
  200. Booth, S., and Wade, R., 2003, Oxygen or air for palliation of breathlessness in advanced cancer, J. R. Soc. Med. 96:215–218.
  201. Bordone, L., and Guarente, L., 2005, Calorie restriction, SIRT1 and metabolism: understanding longevity, Natl. Rev. Mol. Cell Biol. 6:298–305.
  202. Borrego, A., Zamora, Z. B., Gonzalez, R., Romay, C., Menendez, S., Hernandez, F., Montero, T., and Rojas, E., 2004, Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats, Mediators Inflamm. 13:13–19.
  203. Borrelli, E., 2014, Reduction of oxidative stress index after major ozonated autohaemotherapy : is the ozone concentration important? Proceedings of EUROCOOP meeting, October 2 – 5, 2014, Zurich, Switzerland
  204. Borrelli, E., and Bocci, V., 2002, A novel therapeutic option for chronic fatigue syndrome and fibromyalgia, Riv. Ital. Ossigeno Ozonoterapia 1:149–153.
  205. Borrelli, E., Bocci, V., 2013. Visual Improvement Following Ozonetherapy in Dry Age Related Macular Degeneration; a Review. Med Hypothesis Discov Innov Ophthalmol 2, 47–51.
  206. Borrelli, E., Iabichella, M. L., Mosti, G., and Bocci, V., 2008, Topical ozonated autohaemotherapy for the treatment of skin lesions, Int. J. Ozone Ther. 7:103–107.
  207. Bosch-Morell, F., Flohé, L., Marìn, N., and Romero, F. J., 1999, 4-hydroxynonenal inhibits glutathione peroxidase: protection by glutathione, Free Radic. Biol. Med. 26:1383–1387.
  208. Boxer, L. A., and Smolen, J. E., 1988, Neutrophil granule constituents and their release in health and disease, Hematol. Oncol. Clin. N. Am. 2:101–134.
  209. Brahimi-Horn, C., Berra, E., and Pouyssegur, J., 2001, Hypoxia: the tumor’s gateway to progression along the angiogenic pathway, Trends Cell Biol. 11:S32–S36.
  210. Brandes, M. E., Allen, J. B., Ogawa, Y., and Wahl, S. M., 1991, Transforming growth factor b1 suppresses acute and chronic arthritis in experimental animals, J. Clin. Invest. 87:1108–1113.
  211. Brayda-Bruno, M., and Cinnella, P., 1998, Il trattamento dell’ernia discale con infiltrazioni diossigeno-ozono in paravertebrale. in Lombalgie e lombosciatalgie. Criteri di diagnosi e cura (F. Ceccherelli, and A. Ricciardi, Eds.), Edizioni Libreria Cortina, Torino, pp. 361–365.
  212. Brazzelli, M., McKenzie, L., Fielding, S. et al., 2006, Systematic review of the effectiveness and cost-effectiveness of Healozone for the treatment of occlusal pit/fissure caries and root caries, Health Technol. Assess. 16:iii–iv, ix–80.
  213. Bressler, N. M., Bressler, S. B., and Fine, S. L., 1988, Age-related macular degeneration, Surv. Ophthalmol. 32:375–413.
  214. Bridgeman, M. M., Marsden, M., MacNee, W., Flenley, D. C., and Ryle, A. P., 1991, Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine, Thorax 46:39–42.
  215. Brizel, D. M., Scully, S. P., Harrelson, J. M., Layfield, L. J., Bean, J. M., Prosnitz, L. R., and Dewhirst, M. W., 1996, Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma, Cancer Res. 56:941–943.
  216. Broeckaert, F., Arsalane, K., Hermans, C., Bergamaschi, E., Brustolin, A., Mutti, A., and
  217. Bernard, A., 1999, Lung epithelial damage at low concentrations of ambient ozone, Lancet 353:900–901.
  218. Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M., and Soares, M. P., 2000, Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis, J. Exp. Med. 192:1015–1026.
  219. Brownlee, M., 2001, Biochemistry and molecular cell biology of diabetic complications, Nature 414:813–820.
  220. Brownlee, M. A., 2003, A radical explanation for glucose-induced beta cell dysfunction, J. Clin. Invest. 112:1788–1790.
  221. Brownlee, M., 2005, The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54:1615–1625.
  222. Brugnara, C., Gee, B., Armsby, C. C., Kurth, S., Sakamoto, M., Rifai, N., Alper, S. L., and Platt, O.S., 1996, Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease, J. Clin. Invest. 97:1227– 1234.
  223. Brunet, A., Sweeney, L. B., and Sturgill, J. F., 2004, Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase, Science 303:2011–2015.
  224. Bubenìk, J., 1996, Cytokine gene-modified vaccines in the therapy of cancer, Pharmacol. Ther. 69:1–14.
  225. Buege, J. A., and Aust, S. D., 1994, Microsomal lipid peroxidation, Meth. Enzymol. 233:302– 310.
  226. Bulent, U., Mehmet, Y., Nail, E. et al., 2010, Efficacy of hyperbaric oxygen therapy and medical ozone therapy in experimental acute necrotizing pancreatitis, Pancreas 39:9–15.
  227. Bulinin, V. I., Solod, N. V., and Moshurov, I. P., 1995, The first experience of chronic abscesses and pleura emphyemas treatment by the method of ozonization, in The ozone in biology and medicine. 2nd all Russian scientific-practical conference, September 6–8, 1995. Russian association of ozonetherapy, Reshetnikovskaya street 2, Nizhni Novgorod, 603006 Russia, p. 20.
  228. Bulmer, J., Bolton, A. E., and Pockley, A. G., 1997, Effect of combined heat, ozonation and ultraviolet irradiation (VasoCare) on heat shock protein expression by peripheral blood leukocyte populations, J. Biol. Regul. Homeost. Agents 11:104–110.
  229. Burkey, K. O., and Eason, G., 2002, Ozone tolerance in snap bean is associated with elevated ascorbic acid in the leaf apoplast, Physiol. Plant 114:387–394.
  230. Burgassi, S., Zanardi, I., Travagli, V., Montomoli, E., and Bocci, V., 2009, How much ozone bactericidal activity is compromised by plasma components? J. Appl. Microbiol. 106:1715–1721.
  231. Burstein, H. J., Gelber, S., Guadagnoli, E., and Weeks, J. C., 1999, Use of alternative medicine by women with early-stage breast cancer, N. Engl. J. Med. 340:1733–1739.
  232. Bush, R. S., Jenkin, R. D., Allt, W. E., Beale, F. A., Bean, H., Dembo, A. J., and Pringle, J. F., 1978, Definitive evidence for hypoxic cells influencing cure in cancer therapy, Br. J. Cancer Suppl. 37:302–306.
  233. Bustamante, J., Lodge, J. K., Marcocci, L., Tritschler, H., Packer, L., and Rihn, B. H., 1998, alipoic acid in liver metabolism and disease, Free Radic. Biol. Med. 24:1023–1039.
  234. Butterfield, D. A., and Lauderback, C. M., 2002, Lipid peroxidation and protein oxidation in
  235. Alzheimer’s disease brain: potential causes and consequences involving amyloid betapeptideassociated free radical oxidative stress, Free Radic. Biol. Med. 32:1050–1060.
  236. Cacace, F., De Petris, G., and Troiani, A., 2001, Experimental detection of tetraoxygen, Angew. Chem. Int. Ed. Engl. 40:4062–4065.
  237. Cadenas, E., and Davies, K. J., 2000, Mitochondrial free radical generation, oxidative stress, and aging, Free Radic. Biol. Med. 29:222–230.
  238. Calabrese, E. J., 2002, Hormesis: changing view of the dose-response, a personal account of the history and current status, Mutat. Res. 511:181–189.
  239. Calabrese, E. J., and Baldwin, L. A., 2001, Hormesis: U-shaped dose responses and their centrality in toxicology, Trends Pharmacol. Sci. 22:285–291.
  240. Calabrese, E. J., 2009, Getting the dose-response wrong: why hormesis became marginalized and the threshold model accepted, Arch. Toxicol. 83:227–247.
  241. Calder, P. C., 1998, Fat chance of immunomodulation, Immunol. Today 19:244–247.
  242. Caligiuri, M., Murray, C., Buchwald, D., Levine, H., Cheney, P., Peterson, D., Komaroff, A. L., and Ritz, J., 1987, Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome, J. Immunol. 139:3306–3313.
  243. Callahan, J. T., Collecutt, M. F., Lightbody, J. R., and Faragher, B. S., 1982, Alteration of human red blood cells stored in plastic packs, Transfusion 22:154–157.
  244. Campbell, D. E., Fryga, A. S., Bol, S., and Kemp, A. S., 1999, Intracellular interferon-gamma (IFN-g) production in normal children and children with atopic dermatitis, Clin. Exp. Immunol. 115:377–382.
  245. Cannistra, S. A., and Niloff, J. M., 1996, Cancer of the uterine cervix, N. Engl. J. Med. 334: 1030–1038.
  246. Cardile, V., Jiang, X., Russo, A., Casella, F., Renis, M., and Bindoni, M., 1995, Effects of ozone on some biological activities of cells in vitro, Cell Biol. Toxicol. 11:11–21.
  247. Carette, S., Leclaire, R., Marcoux, S., Morin, F., Blaise, G. A., St-Pierre, A., Truchon, R., Parent, F., Lévesque, J., Bergeron, V., Montminy, P., and Blanchette, C., 1997, Epidural corticosteroidinjections for sciatica due to herniated nucleus pulposus, N. Engl. J. Med. 336:1634–1640.
  248. Carlsson, L. M., Jonsson, J., Edlund, T., and Marklund, S. L., 1995, Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia, Proc. Natl. Acad. Sci. USA 92: 6264– 6268.
  249. Carmeliet, P., and Jain, R. K., 2000, Angiogenesis in cancer and other diseases, Nature 407: 249–257.
  250. Carmeliet, P., Dor, Y., Herbert, J. M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., Koch, C. J., Ratcliffe, P., Moons, L., Jain, R. K., Collen, D., Keshert, E., and Keshet, E., 1998, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature 394:485–490.
  251. Carpendale, M. T. F., and Freeberg, J. K., 1991, Ozone inactivates HIV at noncytotoxic concentrations, Antivir. Res. 16:281–292.
  252. Carpendale, M. T., Freeberg, J., and McLeod Griffiss, J., 1993, Does Ozone alleviate AIDS diarrhea? J. Clin. Gastroenterol. 17:142–145.
  253. Cassileth, B. R., and Chapman, C. C., 1996, Alternative and complementary cancer therapies, Cancer 77:1026–1034.
  254. Castagnola, E., Molinari, A. C., Fratino, G., and Viscoli, C., 2003, Conditions associated with infections of indwelling central venous catheters in cancer patients: a summary, Br. J. Haematol. 121:233–239.
  255. Castrini, A., Facchi, T., Prignacca, E., 2002, Efficacy of oxygen-ozone therapy in diabetes mellitus in the dog. Riv. It Ossigeno Ozonoterapia 1:207–210.
  256. Ceballos-Picot, I., Merad-Boudia, M., Nicole, A., Thevenin, M., Hellier, G., Legrain, S., and Berr, C., 1996a, Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer’s type-place of the extracellular glutathione peroxidase, Free Radic. Biol. Med. 20:579–587.
  257. Ceballos-Picot, I., Witko-Sarsat, V., Merad-Boudia, M., Nguyen, A. T., Thévenin, M., Jaudon, M.C., Zingraff, J., Verger, C., Jungers, P., and Descamps-Latscha, B., 1996b, Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure, Free Radic. Biol. Med. 21:845–853.
  258. Ceccherelli, F., Gagliardi, G., Matterazzo, G., Rossato, M., and Giron, G., 1995, La riflessoterapia per agopuntura. in La riflessoterapia per agopuntura (P. Procacci, A. Di Massa, F. Ceccherelli, and R. Casale, Eds.), Edizioni A.I.R.A.S., Padova, pp. 49–77.
  259. Celli, B. R., Thomas, N. E., Anderson, J. A. : et al., 2008, Effect of pharmacotherapy on rate of decline of lung function in COPD: results from the TORCH study, Am. J. Respir. Crit. Care Med. 178:332–338.
  260. Chader, G. J., 2001, PEDF: raising both hopes and questions in controlling angiogenesis, Proc. Natl. Acad. Sci. USA 98:2122–2124.
  261. Chae, H. Z., Kim, K., and Kim, I.-H., 1999, The novel antioxidant enzyme, thioredoxin peroxidase, and mammalian peroxiredoxins. in Redox regulation of cell signaling and its clinical application (L. Packer, and J. Yodoi, Eds), Marcel Dekker, Inc., New York, NY, pp. 85–92.
  262. Chan, W. M., Lam, D. S., Wong, T. H., Lai, T. Y., Kwok, A. K., Tam, B. S., and Li, K. K., 2003, Photodynamic therapy with verteporfin for subfoveal idiopathic choroidal neovascularization: one-year results from a prospective case series, Ophthalmology 110(12):2395–2402.
  263. Chanock, S. J., El Benna, J., Smith, R. M., and Babior, B. M., 1994, The respiratory burst oxidase, J. Biol. Chem. 269:24519–24522.
  264. Chen, Z., Oberley, T. D., Ho, Y., Chua, C. C., Siu, B., Hamdy, R. C., Epstein, C. J., and Chua, B. H., 2000, Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury, Free Radic. Biol. Med. 29:589–596.
  265. Chen, Q., Espey, M. G., Krishna, M. C. et al., 2005, Pharmacologic ascorbic concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues, Proc. Natl. Acad. Sci. USA 102:13604–13609.
  266. Chen, Q., Espey, M. G., Sun, A. Y. et al., 2007, Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo, Proc. Natl. Acad. Sci. USA 104:8749–8754.
  267. Chen, Q., Espey, M. G., Sun, A. Y. et al., 2008, Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice, Proc. Natl. Acad. Sci. USA 105:11105–11109.
  268. Cherkin, D. C., Deyo, R. A., Battie, M., Street, J., and Barlow, W., 1998, A comparison of physical therapy, chiropractic manipulation, and provision of an educational booklet for the treatment of patients with low back pain, N. Engl. J. Med. 339:1021–1029.
  269. Chlebowski, R. T., Schwartz, A. G., Wakelee, H. et al., 2009, Oestrogen plus progestin and lung cancer in postmenopausal women (Women’s Health Initiative trial): a post-hoc analysis of a randomised controlled trial, Lancet 374:1243–1251.
  270. Cho, H. Y., Zhang, L. Y., and Kleeberger, S. R., 2001, Ozone-induced lung inflammation and hyperreactivity are mediated via tumor necrosis factor-alpha receptors, Am. J. Physiol. Lung Cell Mol. Physiol. 280:L537–L546.
  271. Choi, B. M., Pae, H. O., Kim, Y. M., and Chung, H. T., 2003, Nitric oxide-mediated cytoprotection of hepatocytes from glucose deprivation-induced cytotoxicity: involvement of heme oxygenase-1, Hepatology 37:810–823.
  272. Chopdar, A., Chakravarthy, U., and Verma, D., 2003, Age related macular degeneration, BMJ 326:485–488.
  273. Chow, C. K., and Kaneko, J. J., 1979, Influence of dietary vitamin E on the red cells of ozoneexposed rats, Environ. Res. 19:49–55.
  274. Christian, D. L., Chen, L. L., Scannell, C. H., Ferrando, R. E., Welch, B. S., and Balmes, J. R., 1998, Ozone-induced inflammation is attenuated with multiday exposure, Am. J. Respir. Crit. Care Med. 158:532–537.
  275. Chun, T. W., and Fauci, A. S., 1999, Latent reservoirs of HIV: obstacles to the eradication of virus, Proc. Natl. Acad. Sci. USA 96:10958–10961.
  276. Cianci, P., 2004, Advances in the treatment of the diabetic foot: is there a role for adjunctive hyperbaric oxygen therapy? Wound. Repair Regen. 12:2–10.
  277. Cighetti, G., Duca, L., Bortone, L., Sala, S., Nava, I., Fiorelli, G., and Cappellini, M. D., 2002, Oxidative status and malondialdehyde in beta-thalassaemia patients, Eur. J. Clin. Invest. 32(suppl 1):55–60.
  278. Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., and Doerr, H. W., 2003, Treatment of SARS with human interferons, Lancet 362:293–294.
  279. Cinnella, P., and Brayda-Bruno, M., 2001, La nostra esperienza nel trattamento dei conflitti disco-radicolari e delle radicolopatie post-chirurgiche con ossigeno-ozono terapia infiltrativa paravertebrale, Riv. Neuroradiol. 14:75–79.
  280. Clark, C., Buchwald, D., MacIntyre, A., Sharpe, M., and Wessely, S., 2002, Chronic fatigue syndrome: a step towards agreement, Lancet 359:97–98.
  281. Clavo, B., Català, L., Pérez, J. L., Rodrìguez, V., and Robaina, F., 2004, Effect of ozone therapy on cerebral blood flow: a preliminary report, Evid. Based Complement. Alternat. Med., 1(3): 315–319. http://doi.org/10.1093/ecam/neh039
  282. Clavo, B., Perez, J. L., Lopez, L., Suarez, G., Lloret, M., Rodriguez, V., Macias, D., Santana, M., Morera, J., Fiuza, D., Robaina, F., and Gunderoth, M., 2003, Effect of ozone therapy on muscle oxygenation, J. Altern. Complement. Med. 9:251–256.
  283. Clavo, B., Perez, J. L., Lopez, L., Suarez, G., Lloret, M., Rodriguez, V., Macias, D., Santana, M., Hernandez, M. A., Martin-Oliva, R., and Robaina, F., 2004a, Ozone Therapy for Tumor Oxygenation: a Pilot Study, Evid. Based Complement. Alternat. Med. 1:93–98.
  284. Clavo, B., Ruiz, A., Lloret, M., Lopez, L., Suarez, G., Macias, D., Rodriguez, V., Hernandez, M.A., Martin-Oliva, R., Quintero, S., Cuyas, J. M., and Robaina, F., 2004b, Adjuvant ozonetherapy in advanced head and neck tumors: a comparative study, Evid Based Complement Alternat Med. 1(3): 321–325.
  285. Clavo, B., Suarez, G., Aguilar, Y., Gutierrez, D., Ponce, P., Cubero, A., Robaina, F., Carreras, J.L., 2011. Brain ischemia and hypometabolism treated by ozone therapy. Forsch Komplementmed 18, 283–287. doi:10.1159/000333795
  286. Cleare, A. J., Sookdeo, S. S., Jones, J., O’Keane, V., and Miell, J. P., 2000, Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome, J. Clin. Endocrinol. Metab. 85:1433–1439.
  287. Clinton, S. K., 1998, Lycopene: chemistry, biology, and implications for human health and disease, Nutr. Rev. 56:35–51.
  288. Cohen, J., 2002, The immunopathogenesis of sepsis, Nature 420:885–891.
  289. Cohen, J. A., Barkhof, F., Comi, G. et al., 2010, Oral Fingolimod or intramuscular Interferon for relapsing multiple sclerosis, N. Engl. J. Med. 362:402–415.
  290. Cohen, S. M., Olin, K. L., Feuer, W. J., Hjelmeland, L., Keen, C. L., and Morse, L. S., 1994, Low glutathione reductase and peroxidase activity in age-related macular degeneration, Br. J. Ophthalmol. 78:791–794.
  291. Coleman, C. N., 1988, Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity, J. Natl. Cancer Inst. 80:310–317.
  292. Coleman, H. R., Chan, C.-C., Ferris, F. L. I.I.I., and Chew, E. Y., 2008, Age related maculardegeneration, Lancet 372:1835–1845.
  293. Cooke, E. D., Pockley, A. G., Tucker, A. T., Kirby, J. D. T., and Bolton, A. E., 1997, Treatment of severe Raynaud’s syndrome by injection of autologous blood pretreated by heating, ozonation and exposure to ultraviolet light (H-O-U) therapy, Int. Angiol. 16:250–254.
  294. Cooper, E. L., 2004, Effect of ozone therapy on cerebral blood flow: a preliminary report. Evidence Based Complementary and Alternative Medicine, Mar 17 Pub Med does not report the page number.
  295. Cope, H., David, A., Pelosi, A., and Mann, A., 1994, Predictors of chronic “postviral” fatigue, Lancet 344:864–868.
  296. Corey, L., Wald, A., Patel, R., Sacks, S. L., Tyring, S. K., Warren, T., Douglas, J. M., Jr., Paavonen, J., Morrow, R. A., Beutner, K. R., Stratchounsky, L. S., Mertz, G., Keene, O. N., Watson, H. A., Tait, D., and Vargas-Cortes, M., 2004, Once-daily valacyclovir to reduce the risk of transmission of genital herpes, N. Engl. J. Med. 350:11–20.
  297. Cosentino, R., Manca, S., De Stefano, R., Frati, E., Hammoud, M., Manganelli, S., and Marcolongo, R., 2000, Efficacia dell’ozonoterapia nella sindrome fibromialgica, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, p. 30.
  298. Courbat, R., Urfer, D., Walther, J. L., and Mironova, T. A., 2001, Optimisation of disinfection with ozone at full-scale in Nizhny Novgorod, Russia, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 235–249.
  299. Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., Salomon, R. G., and Hollyfield, J. G., 2002, Drusen proteome analysis: an approach to the etiology of age-related macular degeneration, Proc. Natl. Acad. Sci. USA 99:14682–14687.
  300. Cracowski, J. L., Devillier, P., Durand, T., Stanke-Labesque, F., and Bessard, G., 2001, Vascular biology of the isoprostanes, J. Vasc. Res. 38:93–103.
  301. Cruickshanks, K. J., Klein, R., and Klein, B. E., 1993, Sunlight and age-related macular degeneration. The Beaver Dam Eye Study, Arch. Ophthalmol. 111:514–518.
  302. Crumpacker, C. S., 2004, Use of antiviral drugs to prevent herpesvirus transmission, N. Engl. J. Med. 350:67–68.
  303. Csonka, C., Pataki, T., Kovacs, P., Muller, S. L., Schroeter, M. L., Tosaki, A., and Blasig, I. E., 2000, Effects of oxidative stress on the expression of antioxidative defense enzymes in spontaneously hypertensive rat hearts, Free Radic. Biol. Med. 29:612–619.
  304. Csonka, C., Varga, E., Kovacs, P., Ferdinandy, P., Blasig, I. E., Szilvassy, Z., and Tosaki, A., 1999, Heme oxygenase and cardiac function in ischemic/reperfused rat hearts, Free Radic. Biol. Med. 27:119–126.
  305. Cummins, R. O., 1994, Textbook of advanced cardiac life support, Scientific Publishing American Heart Association, Dallas, TX.
  306. Curran, S. F., Amoruso, M. A., Goldstein, B. D., and Berg, R. A., 1984, Degradation of soluble collagen by ozone or hydroxyl radicals, FEBS Lett. 176:155–160.
  307. Curtis-Prior, P., Vere, D., and Fray, P., 1999, Therapeutic value of Ginkgo biloba in reducing symptoms of decline in mental function, J. Pharm. Pharmacol. 51:535–541.
  308. Dale, J. J., Ruckley, C. V., Harper, D. R., Gibson, B., Nelson, E. A., and Prescott, R. J., 1999, Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers, BMJ 319:875–878.
  309. Daly, M. E., Makris, A., Reed, M., and Lewis, C. E., 2003, Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment? J. Natl. Cancer Inst. 95:1660–1673.
  310. D’Ambrosio, C. M., 2002a, Trattamento delle malattie infiammatorie croniche dell’intestino mediante ossigeno-ozonoterapia, Riv. Ital. Ossigeno Ozonoterapia 1:155–158.
  311. D’Ambrosio, C. M., 2002b, Terapia delle IBD mediante ozonoterapia per via rettale, Riv. Ital. Ossigeno Ozonoterapia 1:159–163.
  312. D’Amico, D. J., 1994, Diseases of the retina, N. Engl. J. Med. 331:95–106.
  313. Darouiche, R. O., 2004, Treatment of infections associated with surgical implants, N. Engl. J. Med. 350:1422–1429.
  314. Darzins, P., Mitchell, P., and Heller, R. F., 1997, Sun exposure and age-related macular degeneration. An Australian case- control study, Ophthalmology 104:770–776.
  315. Das, D., Bandyopadhyay, D., Bhattacharjee, M., and Banerjee, R. K., 1997, Hydroxyl radical is the major causative factor in stress-induced gastric ulceration, Free Radic. Biol. Med. 23:8–18.
  316. Das, U. N., 2003, Folic acid says NO to vascular diseases, Nutrition 19:686–692.
  317. Day, R., 2002, Adverse reactions to TNF-alpha inhibitors in rheumatoid arthritis, Lancet 359: 540–541.
  318. De Capua, B., De Felice, C., D’Onza, M., De Lauretis, A., Monaco, G., Cosentino, G., Tassi,
  319. R., Gistri, M., and Passali, D., 2001, [Idiopathic sudden hearing loss: role of the posterior communicating cerebral arteries of the Willis’ circle], Acta Otorhinolaryngol. Ital. 21:144–150.
  320. De Maio, A., 1999, Heat shock proteins: facts, thoughts, and dreams, Shock 11:1–12.
  321. De Maria, N., Colantoni, A., Fagiuoli, S., Liu, G.-J., Rogers, B. K., Farinati, F., van Thiel, D. H., and Floyd, R. A., 1996, Association between reactive oxygen species and disease activity in chronic hepatitis C, Free Radic. Biol. Med. 21:291–295.
  322. De Meirleir, K., Bisbal, C., Campine, I., De Becker, P., Salehzada, T., Demettre, E., and Lebleu, B., 2000, A 37 kDa 2–5A binding protein as a potential biochemical marker for chronic fatigue syndrome, Am. J. Med. 108:99–105.
  323. De Monte, A., van der Zee, H., and Bocci, V., 2005, Major ozonated auto-haemotherapy in chronic limb ischemia with ulcerations, J. Complement. Altern. Med. 11:363–367.
  324. Dedon, P. C., and Tannenbaum, S. R., 2004, Reactive nitrogen species in the chemical biology of inflammation, Arch. Biochem. Biophys. 423:12–22. Degens, H., 1998, Age-related changes in the microcirculation of skeletal muscle, Adv. Exp. Med. Biol. 454:343–348.
  325. Delgado, J., 1991, Tratamiento con ozono del herpes zoster, CENIC Cienc. Biol. 20:160–162.
  326. Denko, N. C., and Giaccia, A. J., 2001, Tumor hypoxia, the physiological link between Trousseau’s syndrome (carcinoma-induced coagulopathy) and metastasis, Cancer Res. 61: 795–798.
  327. Dennog, C., Hartmann, A., Frey, G., and Speit, G., 1996, Detection of DNA damage after hyperbaric oxygen (HBO) therapy, Mutagenesis 11:605–609.
  328. Dernek, S., Tunerir, B., Sevin, B., Aslan, R., Uyguc, O., and Kural, T., 1999, The effects of methylprednisolone on complement, immunoglobulins and pulmonary neutrophil sequestration during cardiopulmonary bypass, Cardiovasc. Surg. 7:414–418.
  329. Devlin, R. B., McDonnell, W. F., Mann, R., Becker, S., House, D. E., Schreinemachers, D., and Koren, H. S., 1991, Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung, Am. J. Respir. Cell Mol. Biol. 4:72–81.
  330. Dewey, W. C., Hopwood, L. E., Sapareto, S. A., and Gerweck, L. E., 1977, Cellular responses to combinations of hyperthermia and radiation, Radiology 123:463–474.
  331. Di Mascio, P., Kaiser, S., and Sies, H., 1989, Lycopene as the most efficient biological carotenoid singlet oxygen quencher, Arch. Biochem. Biophys. 274:532–538.
  332. Di Paolo, N., Bocci, V., Cappelletti, F., Petrini, G., and Gaggiotti, E., 2002, Necrotizing fasciitis successfully treated with extracorporeal blood oxygenation and ozonization (EBOO), Int. J. Artif. Organs 25:1194–1198.
  333. Di Paolo, N., Bocci, V., Garosi, G., Borrelli, E., Bravi, A., Bruci, A., Aldinucci, C., and Capotondo, L., 2000, Extracorporeal blood oxigenation and ozonation (EBOO) in man. Preliminary report, Int. J. Artif. Organs 23:131–141.
  334. Di Paolo, N., Bocci, V., Salvo, D. P. et al., 2005, Extracorporeal blood oxygenation and ozonation (EBOO). A controlled trial in patients with peripheral artery disease, Int. J. Artif. Organs 28:1039–1050.
  335. Dianzani, F., 1999, Chronic hepatitis B, biological basis for new therapeutic strategies, J. Biol. Regul. Homeost. Agents 13:71–79.
  336. Dianzani, M. U., 1998, 4-Hydroxynonenal and cell signalling, Free Radic. Res. 28:553–560.
  337. Diaz, S., Menendez, S., Eng, L., and Fernandez, I., 1995, No increase in sister chromatid exchanges and micronuclei frequencies in human lymphocytes exposed to ozone in vitro, in Proceedings Ozone in Medicine 12th World Congress of the International Ozone Association, 15th to 18th May 1995, Lille France (International Ozone Association, Ed.), Instaprint S.A., Tour,pp. 43–52.
  338. Diaz-Llera, S., Gonzalez-Hernandez, Y., Prieto-Gonzalez, E. A., and Azoy, A., 2002, Genotoxic effect of ozone in human peripheral blood leukocytes, Mutat. Res. 517:13–20.
  339. Didier, C., Pouget, J. P., Cadet, J., Favier, A., Beani, J. C., and Richard, M. J., 2001, Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation, Free Radic. Biol. Med. 30:537–546.
  340. Dinarello, C. A., 1999, IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family, J. Allergy Clin. Immunol. 103:11–24.
  341. Dische, S., Anderson, P. J., Sealy, R., and Watson, E. R., 1983, Carcinoma of the cervix – anaemia, radiotherapy and hyperbaric oxygen, Br. J. Radiol. 56:251–255.
  342. Dobie, R. A., Sakai, C. S., Sullivan, M. D., Katon, W. J., and Russo, J., 1993, Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit, Am. J. Otol. 14:18–23.
  343. Dockrell, H. M., and Playfair, J. H., 1983, Killing of blood-stage murine malaria parasites by hydrogen peroxide, Infect. Immun. 39:456–459.
  344. Dogan, H., and Qalt, S., 2001, Effects of chelating agents and sodium hypochlorite on mineral content of root dentin, J. Endod. 27:578–580.
  345. Dong, Z., Lavrovsky, Y., Venkatachalam, M. A., and Roy, A. K., 2000, Heme oxygenase-1 in tissue pathology: the Yin and Yang, Am. J. Pathol. 156:1485–1488.
  346. Dore, S., 2002, Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer’s disease, Free Radic. Biol. Med. 32:1276–1282.
  347. Doroshow, J. H., 1995, Glutathione peroxidase and oxidative stress, Toxicol. Lett. 82/83:395– 398.
  348. Dreher, D., and Junod, A. F., 1996, Role of oxygen free radicals in cancer development, Eur. J. Cancer 32A:30–38.
  349. DuBois, A. B., 1962, Oxygen toxicity, Anestesiology 23:473–477.
  350. Duckers, H. J., Boehm, M., True, A. L., Yet, S. F., San, H., Park, J. L., Clinton, W. R., Lee, M. E., Nabel, G. J., and Nabel, E. G., 2001, Heme oxygenase-1 protects against vascular constriction and proliferation, Natl. Med. 7:693–698.
  351. Duda, P. W., Schmied, M. C., Cook, S. L., Krieger, J. I., and Hafler, D. A., 2000, Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis, J. Clin. Invest. 105:967–976.
  352. Dumaswala, U. J., Wilson, M. J., Wu, Y. L., Wykle, J., Zhuo, L., Douglass, L. M., and Daleke, D.L., 2000, Glutathione loading prevents free radical injury in red blood cells after storage, Free Radic. Res. 33:517–529.
  353. Durante, W., 2003, Heme oxygenase-1 in growth control and its clinical application to vascular disease, J. Cell Physiol. 195:373–382.
  354. Durelli, L., Verdun, E., Barbero, P., Bergui, M., Versino, E., Ghezzi, A., Montanari, E., and Zaffaroni, M., 2002, Every-other-day interferon beta-1b versus once-weekly interferon beta1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN), Lancet 359:1453–1460.
  355. Dworkin, R. H., 1999, Prevention of postherpetic neuralgia, Lancet 353:1636–1637.
    Página 70 70
  356. Eaton, L., 2003, World cancer rates set to double by 2020, BMJ 326:728.
  357. Ebos, J. M., Lee, C. R., Kerbel, R. S., 2009, Tumor and host-mediated pathways of resistance and diseases progression in response to antiangiogenic therapy. Clin. Cancer Res. 15:5020– 5025.
  358. Edmunds, L. H., Jr., 1998, Inflammatory response to cardiopulmonary bypass, Ann. Thorac. Surg. 66:S12–S16.
  359. Eliakim, R., Karmeli, F., Rachmilewitz, D., Cohen, P., and Zimran, A., 2001, Ozone enema: a model of microscopic colitis in rats, Dig. Dis. Sci. 46:2515–2520.
  360. Emanuel, E. J., Schnipper, L. E., Kamin, D. Y., Levinson, J., and Lichter, A. S., 2003, The costs of conducting clinical research, J. Clin. Oncol. 21:4145–4150.
  361. Emery, P., and Buch, M., 2002, Treating rheumatoid arthritis with tumor necrosis factor alpha blockade, BMJ 324:312–313.
  362. Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., Van Swieten, J. C., Hofman, A., Witteman, J. C., and Breteler, M. M., 2002, Dietary intake of antioxidants and risk of Alzheimer disease, JAMA 287:3223–3229.
  363. Enwonwu, J. W., 1989, Increased metabolic demand for arginine in sickle cell anemia, Med. Sci. Res. 17:997–998.
  364. Ernst, A., and Zibrak, J. D., 1998, Carbon monoxide poisoning, N. Engl. J. Med. 339:1603–1608.
  365. Ernst, E., 1997, Thymus therapy for cancer? A criteria-based, systematic review, Eur. J. Cancer 33:531–535.
  366. Ernst, E., 2001, Mistletoe for cancer? Eur. J. Cancer 37:9–11.
  367. Ernst, E., 2003, The current position of complementary/alternative medicine in cancer, Eur. J. Cancer 39:2273–2277.
  368. Ernst, E., and Cohen, M. H., 2001, Informed consent in complementary and alternative medicine, Arch. Int. Med. 161:2288–2292.
  369. Ernst, E., and Resch, K. L., 1996, Evaluating specific effectiveness of complementary therapies – a position paper, Forsch. Komplementärmed. 3:35–38.
  370. Eskens, F. A., 2004, Angiogenesis inhibitors in clinical development: where are we now and where are we going. Brit. J. Cancer 90:1–7.
  371. Esperanza, S., Ortellado, M., 2011. Ozonoterapia en el tratamiento de Artritis Reumatoide, seguimiento y evolución Desde Setiembre 2006Abril 2011 [Ozone therapy in the treatment of rheumatoid arthritis, monitoring and evolution From September 2006-April 2011]. Presented at the III. Iberoamerican Congress of Ozonetherapy. II. Brazilian Congress of Ozonetherapy. I. Brazilian Congress of Hydro- Ozonetherapy, Rio de Janeiro (Brazil).
  372. Esterbauer, H., Schaur, R. J., and Zollner, H., 1991, Chemistry and biochemistry of 4hydroxynonenal, malonaldehyde and related aldehydes, Free Radic. Biol. Med. 11:81–128.
  373. Evans, H., Bauer, M., Luckman, I., and Page, M., 2001, An assessment of the benefits afforded by the continuous versus intermittent operation of ozone for drinking water treatment, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 219–234.
  374. Evans, J. L., Goldfine, I. D., Maddux, B. A., and Grodsky, G. M., 2002, Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes, Endocr. Rev. 23: 599–622.
  375. Evans, J. R., 2001, Risk factors for age-related macular degeneration, Prog. Retin. Eye Res. 20:227–253.
  376. Fabris, G., Tommasini, G., Petralia, B., Lavaroni, A., De Nardi, F., De Luca, G., Biasizzo, E., and Iaiza, F., 2001, L’ossigeno-ozono terapia intra-foraminale, Riv. Neuroradiol. 14:61–66.
  377. Falk, S. J., Ward, R., and Bleehen, N. M., 1992, The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography, Br. J. Cancer 66: 919– 924.
  378. Falm, E., 2004, Angiogenesis inhibitor in clinical development; where are we now and where are we going? Br. J. Cancer 90:1–7.
  379. Farber, J. L., Kyle, M. E., and Coleman, J. B., 1990, Biology of disease. Mechanisms of cell injury by activated oxygen species, Lab. Invest. 62:670–679.
  380. Farquharson, C. A., Butler, R., Hill, A., Belch, J. J., and Struthers, A. D., 2002, Allopurinol improves endothelial dysfunction in chronic heart failure, Circulation 106:221–226.
  381. Farr, C. H., 1993, Protocol for the intravenous administration of hydrogen peroxide, International Bio-Oxidative Medicine Foundation, Oklahoma City, OK, pp. 29–31.
  382. Faus Vitoria, J., 2006, El ozono y los factores de crecimiento en la curacion de las ulceras. Riv. It Ossigeno Ozonoterapia 5:41–46.
  383. Faus Vitoria, J., 2008, A case of gangrenous pyoderma treated with ozone therapy, Int. J. Ozone Ther. 7:161–165.
  384. Feldmann, M., and Maini, R. N., 2001, Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19:163–196.
  385. Fehervari, Z., and Sakaguchi, S., 2004, Control of Foxp3+CD25+CD4+ regulatory cell activation and function by dentritic cells, Int. Immunol. 16:1769–1780.
  386. Fehervari, Z., and Sakagushi, S., 2005, CD4+ regulatory cells as a potential immunotherapy, Philos. Trans. R. Soc. Lond. B. Biol. Sci. 360:1647–1661.
  387. Fehervari, Z., Sakagushi, S., 2006, Peacekeepers of the immune system. Sci. Am. 295:56–63.
  388. Ferrara, N., 2009, Tumor angiogenesis: VEGF-dependent and independent pathways, Pezcoller Found. J. 19:3–7.
  389. Fialkow, L., Wang, Y., and Downey, G. P., 2007, Reactive oxygen and nitrogen species as signalling molecules regulating neutrophil function, Free Radic. Biol. Med. 42:153–164.
  390. Fields, H. L., 1986, La generazione ectopica di impulsi negli afferenti primari, in Il dolore: meccanismi di insorgenza e trattamento terapeutico McGraw-Hill, pp. 126–129.
  391. Figueroa, M. S., Regueras, A., and Bertrand, J., 1996, Laser photocoagulation to treat macular soft drusen in age-related macular degeneration, Retina 14:391–396.
  392. Filippi, A., 2001, The influence of ozonised water on the epithelial wound healing process in the oral cavity, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 109–116.
  393. Filippi, A., and Kirschner, H., 1995, Ozoniertes Wasser zur Desinfektion und Prophylaxe in der Zahn-Mund-Kieferheilkunde. in Ozon-Handbuch Grundlagen Prävention Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. V-12.2 1–V-12.2 12.
  394. Filippini, G., Munari, L., Incorvaia, B., Ebers, G. C., Polman, C., D’Amico, R., and Rice, G.P., 2003, Interferons in relapsing remitting multiple sclerosis: a systematic review, Lancet 361:545– 552.
  395. Finger, P. T., Gelman, Y. P., Berson, A. M., and Szechter, A., 2003, Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study, Br. J. Ophthalmol. 87: 1497–1503.
  396. Finch, C. E., 2009, Evolution of the human lifespan and diseases of aging: roles of infection, inflammation and nutrition, Proc. Soc. Natl. Acad. Sci. DOI: 10.1073/pnas 0909606106.
  397. Fiocchi, C., 1998, Inflammatory bowel disease: etiology and pathogenesis, Gastroenterology 115:182–205.
  398. Fiocchi, C., 1999, From immune activation to gut tissue injury: the pieces of the puzzle are coming together, Gastroenterology 117:1238–1241.
  399. Fiocchi, C., 2004, Closing fistulas in Crohn’s disease – should the accent be on maintenance or safety? N. Engl. J. Med. 350:934–936.
  400. Fishman, A., Martinez, F., Naunheim, K., Piantadosi, S., Wise, R., Ries, A., Weinmann, G., and Wood, D. E., 2003, A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema, N. Engl. J. Med. 348:2059–2073.
  401. FitzGerald, G. A., and Patrono, C., 2001, The coxibs, selective inhibitors of cyclooxygenase-2, N. Engl. J. Med. 345:433–442.
  402. Flach, J., and Seachrist, L., 1994, Mind-body meld may boost immunity, J. Natl. Cancer Inst. 86:256–258.
  403. Fleischer, A. B., Jr., 1999, Treatment of atopic dermatitis: role of tacrolimus ointment as a topical noncorticosteroidal therapy, J. Allergy Clin. Immunol. 104:S126–S130.
  404. Floyd, R. A., 1999, Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development, Free Radic. Biol. Med. 26: 1346–1355.
  405. Foksinski, M., Bialkowski, K., Skiba, M., Ponikowska, I., Szmurlo, W., and Olinski, R., 1999, Evaluation of 8-oxodeoxyguanosine, typical oxidative DNA damage, in lymphocytes of ozonetreated arteriosclerotic patients, Mutat. Res. 438:23–27.
  406. Folkman, J., 1974, Tumor angiogenesis: role in regulation of tumor growth, Symp. Soc. Dev. Biol. 30:43–52.
  407. Fontana, L., McNeill, K. L., Ritter, J. M., and Chowienczyk, P. J., 1999, Effects of vitamin C and of a cell permeable superoxide dismutase mimetic on acute lipoprotein induced endothelial dysfunction in rabbit aortic rings, Br. J. Pharmacol. 126:730–734.
  408. Fontana, L., Meyer, T. E., Klein, S., and Holloszy, J. O., 2004, Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans, Proc. Natl. Acad. Sci. USA 101:6659–6663.
  409. Forman, H. J., 2008, Hydrogen peroxide: the good, the bad and the ugly, in Oxidants in Biology (G. Valacchi, and P. Davis, Eds.), Springer, Dordrecht, The Netherlands, pp. 1–17.
  410. Forman, H. J., Fukuto, J. M., Miller, T. et al., 2008, The chemistry of cell signalling by reactive oxygen and nitrogen species and 4-hydroxynonenal, Arch. Biochem. Biophys. 477: 183–195.
  411. Frank, R. N., 2004, Diabetic retinopathy, N. Engl. J. Med. 350(1):48–58.
  412. Freeman, B. A., Miller, B. E., and Mudd, J. B., 1979, Reaction of ozone with human erythrocytes, in Assessing toxic effects of environmental pollutants (S. D. Lee, and J. B. Mudd, Eds.), Ann Arbor Science Publishers, Ann Arbor, MI, pp. 151–171.
  413. Frei, B., 1999, On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction, Proc. Soc. Exp. Biol. Med. 222:196–204.
  414. Frei, B., and Lawson, S., 2008, Vitamin C and cancer revisited, Proc. Natl. Acad. Sci. 105: 11037–11038.
  415. Fridovich, I., 1995, Superoxide radical and superoxide dismutases, Annu. Rev. Biochem. 64: 97–112.
  416. Friedman-Kien, A. E., Eron, L. J., Conant, M., Growdon, W., Badiak, H., Bradstreet, P. W., Fedorczyk, D., Trout, J. R., and Plasse, T. F., 1988, Natural interferon alfa for treatment of condylomata acuminata, JAMA. 259:533–538.
  417. Fuchs, J., and Kern, H., 1998, Modulation of UV-light-induced skin inflammation by Dalphatocopherol and L-ascorbic acid: a clinical study using solar simulated radiation, Free Radic. Biol. Med. 25:1006–1012.
  418. Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., and Komaroff, A., 1994, The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group, Ann. Int. Med. 121:953–959.
  419. Fukunaga, K., Nakazono, N., Suzuki, T., and Takama, K., 1999, Mechanism of oxidative damage to fish red blood cells by ozone, IUBMB Life 48:631–634.
  420. Fulle, S., Mecocci, P., Fano, G., Vecchiet, I., Vecchini, A., Racciotti, D., Cherubini, A., Pizzigallo, E., Vecchiet, L., Senin, U., and Beal, M. F., 2000, Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome, Free Radic. Biol. Med. 29:1252–1259.
  421. Fung, W. E., 1991, Interferon alpha 2a for treatment of age-related macular degeneration, Am. J. Ophthalmol. 112:349–350.
  422. Fyles, A., Milosevic, M., Hedley, D., Pintilie, M., Levin, W., Manchul, L., and Hill, R. P., 2002, Tumor hypoxia has independent predictor impact only in patients with node-negative cervix cancer, J. Clin. Oncol. 20:680–687.
  423. Gabriel, C., Blauhut, B., Greul, R., Schneewels, B., and Roggendorf, M., 1996, Transmission of hepatitis C by ozone enrichment of autologous blood, Lancet 347:541.
  424. Galbraith, R., 1999, Heme oxygenase: who needs it? Proc. Soc. Exp. Biol. Med. 222:299–305.
  425. Galleano, M., and Puntarulo, S., 1995, Role of antioxidants on the erythrocytes resistance to lipid peroxidation after acute iron overload in rats, Biochim. Biophys. Acta 1271:321–326.
  426. Galli, F., Jul 22, 2007, Protein damage and inflammation in uraemia and dialysis patients, Nephrol. Dial Transplant 22(suppl 5):v20–v36.
  427. Galli, F., Piroddi, M., Annetti, C. et al., 2005, Oxidative stress and reactive oxygen species, Contrib. Nephrol. 149:240–260.
  428. Garber, G. E., Cameron, D. W., Hawley-Foss, N., Greenway, D., and Shannon, M. E., 1991, The use of ozone-treated blood in the therapy of HIV infection and immune disease: a pilot study of safety and efficacy, AIDS 5:981–984.
  429. Garg, A., 2004, Acquired and inherited lipodystrophies, N. Engl. J. Med. 350:1220–1234.
  430. Gatenby, R. A., Kessler, H. B., Rosenblum, J. S., Coia, L. R., Moldofsky, P. J., Hartz, W. H., and Broder, G. J., 1988, Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy, Int. J. Radiat. Oncol. Biol. Phys. 14:831–838.
  431. Georgiades, E., Behan, W. M., Kilduff, L. P., Hadjicharalambous, M., Mackie, E. E., Wilson, J., Ward, S. A., and Pitsiladis, Y. P., 2003, Chronic fatigue syndrome: new evidence for a central fatigue disorder, Clin. Sci. (Lond) 105:213–218.
  432. Ghiselli, A., Serafini, M., Natella, F., and Scaccini, C., 2000, Total antioxidant capacity as a tool to assess redox status: critical view and experimental data, Free Radic. Biol. Med. 29:1106– 1114.
  433. Ghosh, S., Goldin, E., Gordon, F. H., Malchow, H. A., Rask-Madsen, J., Rutgeerts, P., Vyhnalek, P., Zadorova, Z., Palmer, T., and Donoghue, S., 2003, Natalizumab for active Crohn’s disease, N. Engl. J. Med. 348:24–32.
  434. Ghosh, D., Griswold, J., Erman, M., and Pangborn, W., 2009, Structural basis for androgen specificity and oestrogen synthesis in human aromatase, Nature 457:219–223.
  435. Gionchetti, P., Rizzello, F., Ferrieri, A., Venturi, A., Brignola, C., Ferretti, M., Peruzzo, S., Miglioli, M., and Campieri, M., 1999, Rifaximin in patients with moderate or severe ulcerative colitis refractory to steroid-treatment: a double-blind, placebo-controlled trial, Dig. Dis. Sci. 44: 1220– 1221.
  436. Giovannoni, G., Comi, G., Cook, S. et al., 2010, A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis, N. Engl. J. Med. 362:416–426.
  437. Giunta, R., Coppola, A., Luongo, C., Sammartino, A., Guastafierro, S., Grassia, A., Giunta, L., Mascolo, L., Tirelli, A., and Coppola, L., 2001, Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease, Ann. Hematol. 80:745–748.
  438. Gjonovich, A., Sattin, G. F., Girotto, L., Bordin, M., Gallo, L., and Preciso, G., 2001, Lombalgie ribelli: l’ossigeno-ozono terapia a confronto con altre metodiche, Riv. Neuroradiol. 14:35–38.
  439. Gladwin, M. T., Crawford, J. H., and Patel, R. P., 2004, The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation, Free Radic. Biol. Med. 36:707–717.
  440. Gladwin, M. T., Schechter, A. N., Shelhamer, J. H., Pannell, L. K., Conway, D. A., Hrinczenko, B. W., Nichols, J. S., Pease-Fye, M. E., Noguchi, C. T., Rodgers, G. P., and Ognibene, F. P., 1999, Inhaled nitric oxide augments nitric oxide transport on sickle cell hemoglobin without affecting oxygen affinity, J. Clin. Invest. 104:937–945.
  441. Glover, R. E., Ivy, E. D., Orringer, E. P., Maeda, H., and Mason, R. P., 1999, Detection of nitrosyl hemoglobin in venous blood in the treatment of sickle cell anemia with hydroxyurea, Mol. Pharmacol. 55:1006–1010.
  442. Goldman, M., 1996, Cancer risk of low-level exposure, Science 271:1821–1822.
  443. Goldstein, B. D., and Balchum, O. J., 1967, Effect of ozone on lipid peroxidation in the red blood cell, Proc. Soc. Exp. Biol. Med. 126:356–359.
  444. Gomez, M., Espinosa, E., and Caplan, J. A., 1995, Application of medicinal ozone/oxygen in patients with sickle cell anemia, Townsend Lett. Doctors January:48–52.
  445. Gonzalez, R., Borrego, A., Zamora, Z., Romay, C., Hernandez, F., Menendez, S., Montero, T., and Rojas, A., 2004, Reversion by ozone treatment of acute nephrotoxicity induced by cisplatin in rats, Mediators Inflamm. 13:13–20.
  446. Gooch, P. C., Creasia, D. A., and Brewen, J. G., 1976, The cytogenetic effects of ozone: inhalation and in vitro exposures, Environ. Res. 12:188–195.
  447. Gorre, M. E., Mohammed, M., Ellwood, K., Hsu, N., Paquette, R., Rao, P. N., and Sawyers, C. L., 2001, Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification, Science 293:876–880.
  448. Gracer, R. I., and Bocci, V., 2005, Can the combination of localized “proliferative therapy” with minor ozonated autohemotherapy restore the natural healing process? Med. Hypoth. 65: 752– 759.
  449. Grady, D., Rubin, S. M., Petitti, D. B., Fox, C. S., Black, D., Ettinger, B., Ernster, V. L., and Cummings, S. R., 1992, Hormone therapy to prevent disease and prolong life in postmenopausal women, Ann. Int. Med. 117:1016–1037.
  450. Graham, N., and Paraskeva, P., 2001, Recent studies of ozone disinfection of secondary municipal effluents, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 276–291.
  451. Greenberg, J. An electron microscopical examination of cellular constituents of human whole blood after in vitro exposure to ozone gas. In: International Ozone Association Editors. Proceedings of the 11th Ozone World Congress; 1993 August 29 – September 3; San Francisco, USA. Ozone in Medicine, 1993: M-1-15 – M-1-17.
  452. Greider, C. W., and Blackburn, E. H., 1985, Identification of a specific telomere terminal transferase activity in Tetrahymena extracts, Cell 43:405–413.
  453. Greider, C. W., and Blackburn, E. H., 1987, The telomere terminal transferaase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity, Cell 51:887–898.
  454. Griffin, R. J., Okajima, K., Barrios, B., and Song, C. W., 1996, Mild temperature hyperthermia combined with carbogen breathing increases tumor partial pressure of oxygen (pO2 ) and radiosensitivity, Cancer Res. 56:5590–5593.
  455. Grimaud, E., Heymann, D., and Redini, F., 2002, Recent advances in TGF-beta effects on chondrocyte metabolism. Potential therapeutic roles of TGF-beta in cartilage disorders, Cytokine Growth Factor Rev. 13:241–257.
  456. Grisham, M. B., Granger, D. N., and Lefer, D. J., 1998, Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease, Free Radic. Biol. Med. 25:404–433.
  457. Gross, T. J., and Hunninghake, G. W., 2001, Idiopathic pulmonary fibrosis, N. Engl. J. Med. 345:517–525.
  458. Gubitz, G., and Sandercock, P., 2000, Prevention of ischaemic stroke, BMJ 321:1455–1459.
  459. Guerrero, A., Torres, P., Duran, M. T., Ruiz-Diez, B., Rosales, M., and Rodriguez-Tudela, J.L., 2001, Airborne outbreak of nosocomial Scedosporium prolificans infection, Lancet 357: 1267– 1268.
  460. Gutstein, H. B., 2001, The biologic basis of fatigue, Cancer 92:1678–1683.
  461. Haas, A. F., Wong, J. W., Iwahashi, C. K., Halliwell, B., Cross, C. E., and Davis, P. A., 1998, Redox regulation of wound healing? NF-kappaB activation in cultured human keratinocytes upon wounding and the effect of low energy HeNe irradiation, Free Radic. Biol. Med. 25: 998–1005.
  462. Hack, V., Breitkreutz, R., Kinscherf, R., Rohrer, H., Bartsch, P., Taut, F., Benner, A., and Droge, W., 1998, The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention, Blood 92:59–67.
  463. Hahn, M., Fennerty, M. B., Corless, C. L., Magaret, N., Lieberman, D. A., and Faigel, D. O., 2000, Noninvasive tests as a substitute for histology in the diagnosis of Helicobacter pylori infection, Gastrointest. Endosc. 52:20–26.
  464. Halama, N., Zoernig, I., and Jager, D., 2008, Immunotherapy for cancer-modern immunologic strategies in oncology, Dtsch. Med. Wochenschr. 133:2105–2108.
  465. Halliwell, B., 1994, Free radicals and antioxidants: a personal view, Nutr. Rev. 52:253–265.
  466. Halliwell, B., 1996, Antioxidants in human health and disease, Annu. Rev. Nutr. 16:33–50.
  467. Halliwell, B., 1999a, Antioxidant defence mechanisms: from the beginning to the end (of the beginning), Free Radic. Res. 31:261–272.
  468. Halliwell, B., 1999b, Vitamin C: poison, prophylactic or panacea? Trends Biochem. Sci. 24: 255–259.
  469. Halliwell, B., 2001, Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment, Drugs Aging 18:685–716.
  470. Halliwell, B., 2003, Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett. 540:3–6.
  471. Halliwell, B., Clement, M. V., and And Long, L. H., 2000a, Hydrogen peroxide in the human body, FEBS Lett. 486:10–13.
  472. Halliwell, B., Zhao, K., and Whiteman, M., 2000b, The gastrointestinal tract: a major site of antioxidant action? Free Radic. Res. 33:819–830.
  473. Hamilton, M. L., Van Remmen, H., Drake, J. A., Yang, H., Guo, Z. M., Kewitt, K., Walter, C. A., and Richardson, A., 2001, Does oxidative damage to DNA increase with age? Proc. Natl. Acad. Sci. USA 98:10469–10474.
  474. Hanauer, S. B., and Dassopoulos, T., 2001, Evolving treatment strategies for inflammatory bowel disease, Annu. Rev. Med. 52:299–318.
  475. Hanauer, S. B., Feagan, B. G., Lichtenstein, G. R., Mayer, L. F., Schreiber, S., Colombel, J. F., Rachmilewitz, D., Wolf, D. C., Olson, A., Bao, W., and Rutgeerts, P., 2002, Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial, Lancet 359: 1541–1549.
  476. Haniflin, J. M., and Tofte, S. J., 1999, Update on therapy of atopic dermatitis, J. Allergy Clin. Immunol. 104:S123–S125.
  477. Hannuksela, M. L., and Ellahham, S., 2001, Benefits and risks of sauna bathing, Am. J. Med. 110:118–126.
  478. Hansel, T. T., and Barnes, P. J., 2009, New drugs for exacerbations of chronic obstructive pulmonary disease, Lancet 374:744–755.
  479. Hardwick, C., 1940, The indications for and technique of whole-blood inkìjections, Practitioner 144:79–82.
  480. Harman, D., 1956, A theory based on free radical and radiation chemistry, J. Gerontol. 11:298– 300.
  481. Harman, D., 1972, The biologic clock the mitochondria? J. Am. Geriatr. Soc. 20:145–147.
  482. Harris, A. L., 2002, Hypoxia – a key regulatory factor in tumour growth, Natl. Rev. Cancer 2: 38– 47.
  483. Harris, J. P., Weisman, M. H., Derebery, J. M., Espeland, M. A., Gantz, B. J., Gulya, A. J.,
  484. Hammerschlag, P. E., Hannley, M., Hughes, G. B., Moscicki, R., Nelson, R. A., Niparko, J.K., Rauch, S. D., Telian, S. A., and Brookhouser, P. E., 2003, Treatment of corticosteroidresponsive autoimmune inner ear disease with methotrexate: a randomized controlled trial, JAMA 290:1875–1883.
  485. Harrison, D. E., Strong, R., Sharp, Z. D. et al., 2009, Rapamycin fed late in life extends lifespan in genetically heterogenous mice, Nature 460:392–395.
  486. Hasselwander, O., and Young, I. S., 1998, Oxidative stress in chronic renal failure, Free Radic. Res. 29:1–11.
  487. Hatoum, O. A., Miura, H., and Binion, D. G., 2003, The vascular contribution in the pathogenesis of inflammatory bowel disease, Am. J. Physiol. Heart Circ. Physiol. 285:H1791– H1796.
  488. Hawkins, C. L., and Davies, M. J., 1996, Direct detection and identification of radicals generated during the hydroxyl radical-induced degradation of hyaluronic acid and related materials, Free Radic. Biol. Med. 21:275–290.
  489. Hayflick, L., 1973, The biology of human aging, Am. J. Med. Sci. 265:432–445.
  490. Hayflick, L., 2000, The future of ageing, Nature 408:267–269.
  491. Head, C. A., Brugnara, C., Martinez-Ruiz, R., Kacmarek, R. M., Bridges, K. R., Kuter, D., Bloch,K. D., and Zapol, W. M., 1997, Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo, J. Clin. Invest. 100:1193–1198.
  492. Heaney, M. L., Gardner, J. R., Karasavvas, N. et al., 2008, Vitmain C anatonizes the cytotoxic effects of antineoplastic drugs, Cancer Res. 68:8031–8038.
  493. Helczynska, K., Kronblad, A., Jogi, A., Nilsson, E., Beckman, S., Landberg, G., and Pahlman, S., 2003, Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ, Cancer Res. 63:1441–1444.
  494. Heng, H., Rucker, R. B., Crotty, J., and Dubick, M. A., 1987, The effects of ozone on lung, heart, and liver superoxide dismutase and glutathione peroxidase activities in the protein-deficient rat, Toxicol. Lett. 38:225–237.
  495. Henke, M., Laszig, R., Rube, C., Schafer, U., Haase, K. D., Schilcher, B., Mose, S., Beer, K. T., Burger, U., Dougherty, C., and Frommhold, H., 2003, Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebocontrolled trial, Lancet 362:1255–1260.
  496. Hennekens, C. H., Buring, J. E., and Peto, R., 1994, Antioxidant vitamins – benefits not yet proved, N. Engl. J. Med. 330:1080–1081.
  497. Hermann, M. T., Strong, M. A., Hao, L. Y., and Greider, C. W., 2001, The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability, Cell 107: 67–77.
  498. Hernandez, F., Menendez, S., Wong, R., Gonzalez, M., 1989, [Effect of intravascular ozone therapy on the Glutation Peroxidase system] Rev. CNIC, 20: 37-40.
  499. Hernandez, F., Menendez, S., Wong, R., 1995, Decrease of blood cholesterol and stimulation of antioxidative response in cardiopathy patients treated with endovenous ozone therapy, Free Radic. Biol. Med. 19:115–119.
  500. Hernandez, F., Alvarez, I., Corcho, I., Gonzalez, M., 2004, Changes in glutathione antioxidant pathway components, HLA-DR and IgE in blood from asthma patients treated with ozone therapy, Proceedings of the 15th Ozone World Congress, London, UK. 11th-15th September 2001. Medical Therapy Conference (IOA 2001, Ed.). Ealing, London, UK: Speedprint MacMedia Ltd. pp.l31-141.
  501. Hernandez, F., Calunga, F., Turrent Figueras, J. et al., 2005, Ozone therapy effects on biomarkers and lung function in asthma, Arch. Med. Res. 36:549–554.
  502. Hernandez, F., 2007, To what extent does ozone therapy need a real biochemical control system? assessment and importance of oxidative stress. Arch. Med. Res. 38: 571–578.
  503. Herrmann, M., Voll, R. E., and Kalden, J. R., 2000, Etiopathogenesis of systemic lupus erythematosus, Immunol. Today 21:424–426.
  504. Herzenberg, L. A., De Rosa, S. C., Dubs, J. G., Roederer, M., Anderson, M. T., Ela, S. W., Deresinski, S. C., and Herzenberg, L. A., 1997, Glutathione deficiency is associated with impaired survival in HIV disease, Proc. Natl. Acad. Sci. USA 94:1967–1972.
  505. Hidalgo-Tallón, J., Menéndez-Cepero, S., Vilchez, J.S., Rodríguez-López, C.M., Calandre, E.P., 2012. Ozone Therapy as Add-On Treatment in Fibromyalgia Management by Rectal Insufflation: An Open-Label Pilot Study. J Altern Complement Med. doi:10.1089/acm.2011.0739
  506. Hijnen, W. A. M., Bosklopper, Th. G. J., Hofman, J. A. M. H., Bosch, A. D., and Medema, G. J., 2001, Improvement of the disinfection efficiency of the full-scale ozonation of the River-Iake waterworks of Amsterdam water supply, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 250–261.
  507. Hillerdal, G., 1997, New principles for the treatment of diffuse pulmonary emphysema, J. Int. Med. 242:441–448.
  508. Hirsch, K. R., and Wright, T. L., 2000, The dilemma of disease progression in hepatitis C patients with normal serum aminotransferase levels, Am. J. Med. 109:66–67.
  509. Ho, D. D., 1997, Perspectives series: host/pathogen interactions. Dynamics of HIV-1 replication in vivo, J. Clin. Invest. 99:2565–2567.
  510. Hockel, M., and Vaupel, P., 2001, Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects, J. Natl. Cancer Inst. 93:266–276.
  511. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., and Vaupel, P., 1996, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix, Cancer Res. 56:4509–4515.
  512. Hodgson, H. J., 1996, Keeping Crohn’s disease quiet, N. Engl. J. Med. 334:1599–1600.
  513. Holmboe, E. S., 2002, Oral antihyperglycemic therapy for type 2 diabetes: clinical applications, JAMA 287:373–376.
  514. Holmgren, A., 1989, Thioredoxin and glutaredoxin systems, J. Biol. Chem. 264:13963–13966.
  515. Honess, D. J., Andrews, M. S., Ward, R., and Bleehen, N. M., 1995, Pentoxifylline increases RIF-1 tumour pO2 in a manner compatible with its ability to increase relative tumour perfusion, Acta Oncol. 34:385–389.
  516. Hooper, D. C., Scott, G. S., Zborek, A., Mikheeva, T., Kean, R. B., Koprowski, H., and Spitsin, S. V., 2000, Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood- CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis, FASEB J. 14:691–698.
  517. Hooper, L. V., and Gordon, J. I., 2001, Commensal host-bacterial relationships in the gut, Science 292:1115–1118.
  518. Hoppe, C. C., and Walters, M. C., 2001, Bone marrow transplantation in sickle cell anemia, Curr. Opin. Oncol. 13:85–90.
  519. Hornsby, P. J., 1995, Biosynthesis of DHEAS by the human adrenal cortex and its age-related decline. Ann. NY Acad. Sci. 774:29–46.
  520. Horsman, M. R., Chaplin, D. J., and Brown, J. M., 1989, Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation, Radiat. Res. 118:139–150.
  521. Houston, M., Estevez, A., Chumley, P., Aslan, M., Marklund, S., Parks, D. A., and Freeman, B. A., 1999, Binding of xanthine oxidase to vascular endothelium. Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling, J. Biol. Chem. 274: 4985–4994.
  522. Hrinczenko, B. W., Alayash, A. I., Wink, D. A., Gladwin, M. T., Rodgers, G. P., and Schechter, A. N., 2000, Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport, Br. J. Haematol. 110:412–419.
  523. Hruz, P. W., Murata, H., and Mueckler, M., 2001, Adverse metabolic consequences of HIV protease inhibitor therapy: the search for a central mechanism, Am. J. Physiol. Endocrinol. Metab. 280:E549–E553.
  524. Hu, M.-L., 1994, Measurement of protein thiol groups and glutathione in plasma, Meth. Enzymol. 233:380–385.
  525. Huang, L. E., and Bunn, H. F., 2003, Hypoxia-inducible factor and its biomedical relevance, J. Biol. Chem. 278:19575–19578.
  526. Hui, C. K., Yuen, M. F., Sablon, E., Chan, A. O., Wong, B. C., and Lai, C. L., 2003, Interferon and ribavirin therapy for chronic hepatitis C virus genotype 6: a comparison with genotype 1, J. Infect. Dis. 187:1071–1074.
  527. Humayun, M. S., 2001, Intraocular retinal prosthesis, Trans. Am. Ophthalmol. Soc. 99:271–300. Ikeda, F., Shimomura, H., Miyake, M., Fujioka, S. I., Itoh, M., Takahashi, A., Iwasaki, Y., Sakaguchi, K., Yamamoto, K., Higashi, T., and Tsuji, T., 2000, Early clearance of circulating hepatitis C virus enhanced by induction therapy with twice-a-day intravenous injection of IFNbeta, J. Interferon Cytokine Res. 20:831–836.
  528. Ikonomidis, S., Tsaousis, P., Fyntanis, A. et al., 2005, New data regarding the use of oxidative stress (ozone therapy) in the former Soviet Union countries, Riv. Ital. Ossigeno Ozonoterapia 4:40–43.
  529. Imray, C. H., Walsh, S., Clarke, T., Tiivas, C., Hoar, H., Harvey, T. C., Chan, C. W., Forster, P. J., Bradwell, A. R., and Wright, A. D., 2003, Effects of breathing air containing 3% carbon dioxide, 35% oxygen or a mixture of 3% carbon dioxide/35% oxygen on cerebral and peripheral oxygenation at 150 m and 3459 m, Clin. Sci. (Lond) 104:203–210.
  530. Inaba, D., Ruben, J., Takagi, O., and Arends, J., 1996, Effect of sodium hypochlorite treatment on remineralization of human root dentine in vitro, Caries Res. 30:218–224.
  531. Inch, W. R., McCredie, J. A., and Sutherland, R. M., 1970, Effect of duration of breathing 95 percent oxygen plus 5 percent carbon dioxide before x-irradiation on cure of C3H mammary tumor, Cancer 25:926–931.
  532. Inui, Y., and Ichiyanagi, I., 2001, “Ozone Cleaner for Bedding, Bedclothes, etc.”, Japanese Patent 2001 161797 A2 (Assignee: Yasunaga K.K.).
  533. Inzucchi, S. E., 2002, Oral antihyperglycemic therapy for type 2 diabetes: scientific review, JAMA 287:360–372.
  534. Iuliano, L., Colavita, A. R., Leo, R., Praticò, D., and Violi, F., 1997, Oxygen free radicals and platelet activation, Free Radic. Biol. Med. 22:999–1006.
  535. Izzo, A., 2008, Oxygen-Ozone treatment of leg ulcers, Int. J. Ozone Ther. 7:126–135.
  536. Jackson, K. A., Majka, S. M., Wang, H., Pocius, J., Hartley, C. J., Majesky, M. W., Entman, M. L., Michael, L. H., Hirschi, K. K., and Goodell, M. A., 2001, Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells, J. Clin. Invest. 107:1395–1402.
  537. Jacobs, M.-T., 1982, Untersuchung uber Zwischenfalle und typische Komplikationen in der OzonSauerstoff-Therapie, OzoNachrichten 1:5.
  538. Jacobson, M. D., 1996, Reactive oxygen species and programmed cell death, Trends Biochem. Sci. 21:83–86.
  539. Jaeschke, H., 1995, Mechanisms of oxidant stress-induced acute tissue injury, Proc. Soc. Exp. Biol. Med. 209:104–111.
  540. Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W., Fong, H. H., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., and Pezzuto, J. M., 1997, Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Science 275:218–220.
  541. Jeffcoate, W. J., and Harding, K. G., 2003, Diabetic foot ulcers, Lancet 361:1545–1551.
  542. Jenner, P., 1994, Oxidative damage in neurodegenerative disease, Lancet 344:796–798.
  543. Jerrett, M., Burnett, R. T., Pope, C. A. et al., 2009, Long-term ozone exposure and mortality, N. Engl. J. Med. 360:1085–1095.
  544. Jia, L., Bonaventura, C., Bonaventura, J., and Stamler, J. S., 1996, S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control, Nature 380:221–226.
  545. Jiang, J., Jordan, S. J., Barr, D. P., Gunther, M. R., Maeda, H., and Mason, R. P., 1997, In vivo production of nitric oxide in rats after administration of hydroxyurea, Mol. Pharmacol. 52:1081– 1086.
  546. Jindal, N., and Dellinger, R. P., 2000, Inhalation of nitric oxide in acute respiratory distress syndrome, J. Lab. Clin. Med. 136:21–28.
  547. Johnson, P. W., Dixon, R., and Ross, A. D., 1998, An in-vitro test for assessing the viability of Ascaris suum eggs exposed to various sewage treatment processes, Int. J. Parasitol. 28: 627– 633.
  548. Johnson, R. J., Willson, R., Yamabe, H., Couser, W., Alpers, C. E., Wener, M. H., Davis, C., and Gretch, D. R., 1994, Renal manifestations of hepatitis C virus infection, Kidney Int. 46: 1255–1263.
  549. Jolly, C., and Morimoto, R. I., 2000, Role of the heat shock response and molecular chaperones in oncogenesis and cell death, J. Natl. Cancer Inst. 92:1564–1572.
  550. Jordan, L., Beaver, K., and Foy, S., 2002, Ozone treatment for radiotherapy skin reactions: is there an evidence base for practice? Eur. J. Oncol. Nurs. 6:220–227.
  551. Jornot, L., Mirault, M. E., and Junod, A. F., 1991, Differential expression of hsp70 stress proteins in human endothelial cells exposed to heat shock and hydrogen peroxide, Am. J. Respir. Cell Mol. Biol. 5:265–275.Joyce, J., Rabe-Hesketh, S., and Wessely, S., 1998, Reviewing the reviews: the example of chronic fatigue syndrome, JAMA 280:264–266. Joyner, M. J., and Dietz, N. M., 1997, Nitric oxide and vasodilation in human limbs, J. Appl. Physiol. 83:1785–1796.
  552. Jucopilla, N., Ferrarese, C., Tirapelle, G., Battista, R., Mazzo, G., and Robert, A., 2000, Infiltrazioni disco-foraminali con O2 –O3 nelle SDR da conflitto disco-radicolari lombari, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, p. 38.
  553. Kadokawa, N., Morioka, T., Motoyama, N., Hashino, M., Mori, Y., Nishijima, W., Okada, M., and Moniwa, T., 2001, Advanced water treatment using ozone resistant microfiltration membrane, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 125–133.
  554. Kalebic, T., Kinter, A., Poli, G., Anderson, M. E., Meister, A., and Fauci, A. S., 1991, Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine, Proc. Natl. Acad. Sci. USA 88:986–990.
  555. Kamp, D. W., 2003, Idiopathic pulmonary fibrosis: the inflammation hypothesis revisited, Chest 124:1187–1190.
  556. Kang, H. J., Kim, H. S., Zhang, S. Y., Park, K. W., Cho, H. J., Koo, B. K., Kim, Y. J., Soo Lee, D., Sohn, D. W., Han, K. S., Oh, B. H., Lee, M. M., and Park, Y. B., 2004, Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial, Lancet 363:751–756.
  557. Kappos, L., Radue, E. W., and O’Connor, P., 2010, A placebo-controlled trial of oral Fingolimod in relapsing multiple sclerosis, N. Engl. J. Med. in press.
  558. Karandikar, N. J., Crawford, M. P., Yan, X., Ratts, R. B., Brenchley, J. M., Ambrozak, D. R., Lovett-Racke, A. E., Frohman, E. M., Stastny, P., Douek, D. C., Koup, R. A., and Racke, M. K., 2002, Glatiramer acetate (Copaxone) therapy induces CD8(+) T cell responses in patients with multiple sclerosis, J. Clin. Invest. 109:641–649.
  559. Karp, C. L., Biron, C. A., and Irani, D. N., 2000, Interferon beta in multiple sclerosis: is IL-12 suppression the key? Immunol. Today 21:24–28.
  560. Karppinen, J., Korhonen, T., Malmivaara, A., Paimela, L., Kyllonen, E., Lindgren, K. A., Rantanen, P., Tervonen, O., Niinimaki, J., Seitsalo, S., and Hurri, H., 2003, Tumor necrosis factor-alpha monoclonal antibody, infliximab, used to manage severe sciatica, Spine 28:750– 753.
  561. Kashiba, M., Kasahara, E., Chien, K. C., and Inoue, M., 1999, Fates and vascular action of Snitrosoglutathione and related compounds in the circulation, Arch. Biochem. Biophys. 363: 213–218.
  562. Kasumjan, S. A., Lelyanov, A. D., Guseva, E. D., and Alexeev, B. P., 1995, The ozonetherapy of the acute suppurative infection, in The ozone in biology and medicine. 2nd all Russian Scientific-Practical Conference, September 6–8, 1995. Russian association of ozonetherapy, Reshetnikovskaya street 2, Nizhni Novgorod, 603006 Russia, p. 16.
  563. Katano, H., Pesnicak, L., and Cohen, J. I., 2004, Simvastatin induces apoptosis of EpsteinBarr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas, Proc, Natl. Acad. Sci. USA 101:4960–4965.
  564. Kaul, D. K., Tsai, H. M., Liu, X. D., Nakada, M. T., Nagel, R. L., and Coller, B. S., 2000, Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cellendothelium interactions induced by platelet-activating factor, Blood 95:368–374.
  565. Keane, J., Gershon, S., Wise, R. P., Mirabile-Levens, E., Kasznica, J., Schwieterman, W. D., Siegel, J. N., and Braun, M. M., 2001, Tuberculosis associated with infliximab, a tumor necrosis factor alpha- neutralizing agent, N. Engl. J. Med. 345:1098–1104. Keane, M. P., and Strieter, R. M., 2002, The importance of balanced pro-inflammatory and antiinflammatory mechanisms in diffuse lung disease, Respir. Res. 3:5.
  566. Keegan, B. M., and Noseworthy, J. H., 2002, Multiple sclerosis, Annu, Rev. Med. 53:285–302.
  567. Kelly, F. J., Mudway, I., Krishna, M. T., and Holgate, S. T., 1995, The free radical basis of air pollution: focus on ozone, Resp. Med. 89:647–656.
  568. Kiang, J. G., and Tsokos, G. C., 1998, Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology, Pharmacol. Ther. 80:183–201.
  569. Kief, H., 1993, The treatment of malignant diseases with AHIT, in Proceedings: IOA Congress, San Francisco, CA (International Ozone Association, Ed.), pp. 26–31.
  570. Kim, C. H., Choi, H., Chun, Y. S., Kim, G. T., Park, J. W., and Kim, M. S., 2001, Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium, Pflugers. Arch. 442:519–525.
  571. Kim, N. W., Piatyszek, M. A., Prowse, kR. et al., 1994, Specific association of human telomerase activity with immortal cells and cancer, Science 266:2011–2015.
  572. Kimberlin, D. W., and Rouse, D. J., 2004, Clinical practice. Genital herpes, N. Engl. J. Med. 350:1970–1977.
  573. Kimura, I., Shinoda, K., Tanino, T., Ohtake, Y., Mashima, Y., and Oguchi, Y., 2003, Scanning laser Doppler flowmeter study of retinal blood flow in macular area of healthy volunteers, Br. J. Ophthalmol. 87:1469–1473.
  574. Kindwall, E. P., 1993, Hyperbaric Oxygen, BMJ 307:515–516.
  575. King, G. L., and Suzuma, K., 2000, Pigment-epithelium-derived factor – a key coordinator of retinal neuronal and vascular functions, N. Engl. J. Med. 342:349–351.
  576. Kinnula, V. L., and Crapo, J. D., 2004, Superoxide dismutases in malignant cells and human tumors, Free Radic, Biol. Med. 36:718–744.
  577. Kipnis, J., Yoles, E., Porat, Z., Cohen, A., Mor, F., Sela, M., Cohen, I. R., and Schwartz, M., 2000, T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies, Proc, Natl. Acad. Sci. USA 97:7446–7451.
  578. Kirby, P. K., Kiviat, N., Beckman, A., Wells, D., Sherwin, S., and Corey, L., 1988, Tolerance and efficacy of recombinant human interferon gamma in the treatment of refractory genital warts, Am. J. Med. 85:183–188.
  579. Kleeberger, S. R., Levitt, R. C., Zhang, L. Y., Longphre, M., Harkema, J., Jedlicka, A., Eleff, S. M., DiSilvestre, D., and Holroyd, K. J., 1997, Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice, Nat. Genet. 17:475–478.
  580. Klein HG, Anstee DJ., 2014, Mollison’s Blood Transfusion in Clinical Medicine – 12th edition, Malden (MA): Oxford: Blackwell Publishing.
  581. Klein, R., Klein, B. E., and Franke, T., 1993, The relationship of cardiovascular disease and its risk factors to age- related maculopathy. The Beaver Dam Eye Study, Ophthalmology 100:406–414.
  582. Klein, R., Klein, B. E., Jensen, S. C., and Meuer, S. M., 1997, The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study, Ophthalmology 104:7–21.
  583. Klomp, H. M., Spincemaille, G. H. J. J., Steyerberg, E. W., Habbema, J. D. F., and van Urk, H., and for the ESES study group, 1999, Spinal-cord stimulation in critical limb ischaemia: a randomised trial, Lancet 353:1040–1044.
  584. Knoch, H.-G., and Klug, W., 1990, Ozon-Sauerstoff-Therapie der Proktitis, Med. Welt. 41: 371– 374.
  585. Knoch, H.-G., Roschke, W., and Klug, W., 1987, Ozone/oxygen therapy in proctology, OzoNachrichten 6:51–70.
  586. Knudsen, P. J., Leon, J., Ng, A. K., Shaldon, S., Floege, J., and Koch, K. M., 1989, Hemodialysisrelated induction of beta-2 – microglobulin and interleukin-1 synthesis and release by mononuclear phagocytes, Nephron 53:188–193.
  587. Kohner, E., 2003a, Extracts from “concise clinical evidence”. Commentary: treatment of diabetic retinopathy, BMJ 326:1023–1025.
  588. Kohner, E. M., 2003b, Aspirin for diabetic retinopathy, BMJ 327:1060–1061.
  589. Kokura, S., Yoshida, N., and Yoshikawa, T., 2002, Anoxia/reoxygenation-induced leukocyteendothelial cell interactions, Free Radic. Biol. Med. 33:427–432.
  590. Kollef, M. H., and Fraser, V. J., 2001, Antibiotic resistance in the intensive care unit, Ann. Intern. Med. 134:298–314.
  591. Komaroff, A. L., 2000, The biology of chronic fatigue syndrome, Am. J. Med. 108:169–171.
  592. Komaroff, A. L., and Buchwald, D. S., 1998, Chronic fatigue syndrome: an update, Annu. Rev. Med. 49:1–13.
  593. Kondo, S., Toyokuni, S., Iwasa, Y., Tanaka, Y., Onodera, H., Hiai, H., and Imamura, M., 1999, Persistent oxidative stress in human colorectal carcinoma, but not in adenoma, Free Radic. Biol. Med. 27:401–410.
  594. Konrad, H., 1995, Ozone therapy for herpes simplex and herpes zoster, in Proceedings Ozone in Medicine, 12th World Congress of the International Ozone Association, Lille, France, 15th– 18th May 1995 (International Ozone Association, Ed.), Instaprint S.A., Tours, pp. 187–194.
  595. Konrad, H., 2001, Ozone therapy for post-herpetic neuralgia. A retrospective study of 55 cases, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 85–88.
  596. Konstantinov, K., von Mikecz, A., Buchwald, D., Jones, J., Gerace, L., and Tan, E. M., 1996, Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome, J. Clin. Invest. 98:1888–1896.
  597. Kotler, D. P., 2003, HIV infection and lipodystrophy, Prog. Cardiovasc. Dis. 45:269–284.
  598. Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F. et al., 2009, Mitochondria and reactive oxygen species, Free Radic. Biol. Med. in press, May 7.
  599. Kraft, K., Stenkamp, E., Sachinidis, A., Seewald, S., and Vetter, H., 1998, Effect of autohemotherapy with ozone on cardiovascular risk factors in patients with mild hypertension, Perfusion11:216–219.
  600. Kramer, B. S., and Klausner, R. D., 1997, Grappling with cancer, Defeatism versus the reality of progress, N. Engl. J. Med. 337:931–934.
  601. Kremer, J. M., Westhovens, R., Leon, M., Di Giorgio, E., Alten, R., Steinfeld, S., Russell, A., Dougados, M., Emery, P., Nuamah, I. F., Williams, G. R., Becker, J. C., Hagerty, D. T., and Moreland, L. W., 2003, Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig, N. Engl. J. Med. 349:1907–1915.
  602. Krinsky, N. I., Landrum, J. T., and Bone, R. A., 2003, Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye, Annu. Rev. Nutr. 23:171–201.
  603. Kruger, C., Greten, T. F., and Korangy, F., 2007, Immune based therapies in cancer, Histol. Histopathol. 22:687–696.
  604. Kudravcev, B. P., Miroshin, S. J., and Semyonov, S. V., 1995, The use of ozonized solutions in complex treatment of peritonitis, in The ozone in biology and medicine. 2nd All Russian Scientific-Practical Conference, September 6–8, 1995, Russian Association of Ozonetherapy, Reshetnikovskaya stret, 2 – Nizhni Novgorod, 603006 Russia, Nizhni Novgorod, p. 20.
  605. Kumaraguruparan, R., Subapriya, R., Viswanathan, P., and Nagini, S., 2002, Tissue lipid peroxidation and antioxidant status in patients with adenocarcinoma of the breast, Clin. Chim. Acta 325:165–170.
  606. Kume, M., Yamamoto, Y., Saad, S., Gomi, T., Kimoto, S., Shimabukuro, T., Yagi, T., Nakagami, M., Takada, Y., Morimoto, T., and Yamaoka, Y., 1996, Ischemic preconditioning of the liver in rats: implications of heat shock protein induction to increase tolerance of ischemia-reperfusion injury, J. Lab. Clin. Med. 128:251–258.
  607. Kupper, T. S., 2003, Immunologic targets in psoriasis, N. Engl. J. Med. 349:1987–1990.
  608. Kuruvilla, A. P., Shah, R., Hochwald, G. M., Liggitt, H. D., Palladino, M. A., and Thorbecke, G. J., 1991, Protective effect of transforming growth factor b1 on experimental autoimmune diseases in mice., Proc. Natl. Acad. Sci. USA 88:2918–2921.
  609. Labow, R. S., Tocchi, M., and Rock, G., 1986, Contamination of platelet storage bags by phthalate esters, Toxicol. Environ. Health 19:591–598.
  610. Laitinen, M., Mäkinen, K., Manninen, H., Matsi, P., Kossila, M., Agrawal, R. S., Pakkanen, T., Luoma, J. S., Viita, H., Hartikainen, J., Alhava, E., Laakso, M., and Ylä-Herttuala, S., 1998, Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia, Hum. Gene. Ther. 9:1481–1486.
  611. Lalezari, J. P., Henry, K., O’Hearn, M., Montaner, J. S., Piliero, P. J., Trottier, B., Walmsley, S., Cohen, C., Kuritzkes, D. R., Eron, J. J., Jr., Chung, J., DeMasi, R., Donatacci, L., Drobnes, C., Delehanty, J., and Salgo, M., 2003, Enfuvirtide, an HIV-1 fusion inhibitor, for drug-resistant HIV infection in North and South America, N. Engl. J. Med. 348:2175–2185. Lal, G., and Bromberg, J. S., 2009, Epigenetic mechanisms of regulation of Foxp3 esxpression, Blood 114:3727–3735.
  612. Lamberts, S. W., van den Beld, A. W., and van der Lely, A. J., 1997, The endocrinoly of aging, Science 278:419–424.
  613. Lambeth, J. D., 2004, NOX enzymes and the biology of reactive oxygen, Nat. Rev. Immunol. 4:181–189.
  614. Landay, A. L., Jessop, C., Lennette, E. T., and Levy, J. A., 1991, Chronic fatigue syndrome: clinical condition associated with immune activation, Lancet 338:707–712.
  615. Lane, R., and Phillips, M., 2003, Rhabdomyolysis, BMJ 327:115–116.
  616. Lang, A. E., and Lozano, A. M., 1998a, Parkinson’s disease. First of two parts, N. Engl. J. Med. 339:1044–1053.
  617. Lang, A. E., and Lozano, A. M., 1998b, Parkinson’s disease. Second of two parts, N. Engl. J. Med. 339:1130–1143.
  618. Langen, R. C., Korn, S. H., and Wouters, E. F., 2003, ROS in the local and systemic pathogenesis of COPD, Free Radic. Biol. Med. 35:226–235.
  619. Larbi, A., Franceschi, C., Mazzatti, D. et al., 2008, Aging of the immune system as a prognostic factor for human longevity, Physiology (Bethesda) 23:64–74.
  620. Larini, A., and Bocci, V., 2004, Effects of ozone on isolated peripheral blood mononuclear cells, Toxicol. Vitro. in press.
  621. Larini, A., Bianchi, L., and Bocci, V., 2003, The ozone tolerance: (I) Enhancement of antioxidant enzymes is ozone dose-dependent in Jurkat cells, Free Radic. Res. 37: 1163–1168.
  622. Larini, A., Bianchi, L., and Bocci, V., 2004, Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells, Free Radic. Res. 38:509–516.
  623. Larrea, E., Beloqui, O., Muñoz-Navas, M. A., Civeira, M. P., and Prieto, J., 1998, Superoxide dismutase in patients with chronic hepatitis C virus infection, Free Radic. Biol. Med. 24: 1235– 1241.
  624. Last, J. A., Warren, D. L., Pecquet-Goad, E., and Witschi, H., 1987, Modification by ozone of lung tumor development in mice, J. Natl. Cancer Inst. 78:149–154.
  625. Lawrence, W. H., 1978, Phthalate esters: the question of safety, Clin. Toxicol. 13:89.
  626. Leach, R. M., Rees, P. J., and Wilmshurst, P., 1998, Hyperbaric oxygen therapy, BMJ 317: 1140–1143.
  627. Lebwohl, M., Tyring, S. K., Hamilton, T. K., Toth, D., Glazer, S., Tawfik, N. H., Walicke, P., Dummer, W., Wang, X., Garovoy, M. R., and Pariser, D., 2003, A novel targeted T-cell modulator, efalizumab, for plaque psoriasis, N. Engl. J. Med. 349:2004–2013.
  628. Lederman, R. J., Mendelsohn, F. O., Anderson, R. D., Saucedo, J. F., Tenaglia, A. N., Hermiller, J. B., Hillegass, W. B., Rocha-Singh, K., Moon, T. E., Whitehouse, M. J., and Annex, B. H., 2002, Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial, Lancet 359:2053–2058.
  629. Lee, T. S., and Chau, L. Y., 2002, Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice, Nat. Med. 8:240–246.
  630. Leist, M., Raab, B., Maurer, S., and Brigelius-Flohé, R., 1996, Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity, Free Radic. Biol. Med. 21:297–306.
  631. León, O. S., Menéndez, S., Merino, N., Castillo, R., Sam, S., Pérez, L., Cruz, E., and Bocci, V., 1998, Ozone oxidative preconditioning: a protection against cellular damage by free radicals, Mediators Inflamm. 7:289–294.
  632. Leonardi, C. L., Powers, J. L., Matheson, R. T., Goffe, B. S., Zitnik, R., Wang, A., and Gottlieb, A. B., 2003, Etanercept as monotherapy in patients with psoriasis, N. Engl. J. Med. 349: 2014– 2022.
  633. Leonardi, M., Simonetti, L., and Barbara, C., 2001, Effetti dell’ozono sul nucleo polposo: reperti anatomo-patologici su un caso operato, Riv. Neuroradiol. 14:57–59.
  634. Lescai, F., Blanchè, H., Nebel, A. et al., 2009, Human longevità and IIp15.5: a study in 1321 centenarians, Eur. J. Hum. Genet. 17:1515–1519.
  635. Letterio, J. J., and Roberts, A. B., 1998, Regulation of immune responses by TGF-b, Annu. Rev. Immunol. 16:137–161.
  636. Leung, D. Y., 1999, Pathogenesis of atopic dermatitis, J. Allergy Clin. Immunol. 104:S99–S108.
  637. Levi, F., Lucchini, F., Negri, E., Boyle, P., and La Vecchia, C., 1999, Cancer mortality in Europe, 1990–1994, and an overview of trends from 1955 to 1994, Eur. J. Cancer 35:1477–1516.
  638. Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., and Cantilena, L. R., 1996, Vitamin C pharmacokinetics in health volunteers: evidence for a recommended dietary allowance, Proc. Natl. Acad. Sci. USA 93:3704–3709.
  639. Levine, M., Daruwala, R. C., Park, J. B., Rumsey, S. C., and Wang, Y., 1998, Does vitamin C have a pro-oxidant effect? Nature 395:231.
  640. Levine, M., Espey, M. G., and Chen, Q., 2009, Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment, Free Radic. Biol. Med. 47:27–29.
  641. Levine, R. L., 2002, Carbonyl modified proteins in cellular regulation, aging, and disease, Free Radic. Biol. Med. 32:790–796.
  642. Lewin, N., Craik, S., Li, H., Smith, D. W., and Belosevic, M., 2001, Sequential inactivation of Cryptosporidium using ozone followed by free chlorine in natural water, Ozone Sci. Eng. 23:411–420.
  643. Lewis, L. M., Flechtner, T. W., Kerkay, J., Pearson, K. H., Chen, W. T., Popowniak, K. L., and Nakamoto, S., 1977, Determination of plasticizer levels in serum of hemodialysis patients, Trans. Am. Soc. Artif. Intern. Organs 23:566–572.
  644. Li, C. K., Chan, P. K., Ling, S. C., and Ha, S. Y., 2002, Interferon and ribavirin as frontline treatment for chronic hepatitis C infection in thalassaemia major, Br. J. Haematol. 117: 755–758.
  645. Li, P. A., Liu, G. J., He, Q. P., Floyd, R. A., and Siesjo, B. K., 1999, Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia, Free Radic. Biol. Med. 27:1033–1040.
  646. Liao, J. K., 2002, Isoprenoids as mediators of the biological effects of statins, J. Clin. Invest. 110:285–288.
  647. Liaw, K.-L., Glass, A. G., Manos, M. M., Greer, C. E., Scott, D. R., Sherman, M., Burk, R. D., Kurman, R. J., Wacholder, S., Rush, B. B., Cadell, D. M., Lawler, P., Tabor, D., and Schiffman, M., 1999, Detection of human papillomavirus DNA in cytologically normal women and subsequent cervical squamous intraepithelial lesions, J. Natl. Cancer Inst. 91: 954–960.
  648. Lilienfeld, D. E., and Perl, D. P., 1993, Projected neurodegenerative disease mortality in the United States, 1990–2040, Neuroepidemiology 12:219–228.
  649. Lindner, A., Charra, B., Sherrard, D. J., and Scribner, B. H., 1974, Accelerated atherosclerosis in prolonged maintenance hemodialysis, N. Engl. J. Med. 290:697–701.
  650. Liou, C. T., Wang, J. S., and Ooi, H. K., 2002, Effect of ozone treatment on Eimeria colchici oocysts, J. Parasitol. 88:159–162.
  651. Lippman, M., 1989, Health effects of ozone, a critical review, J. Am. Air Pollut. Control Assoc. 39:672–695.
  652. Littlewood, T. J., Bajetta, E., Nortier, J. W., Vercammen, E., and Rapoport, B., 2001, Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial, J. Clin. Oncol. 19:2865–2874.
  653. Liu, H., Bravata, D. M., Olkin, I. et al., 2007, Systematic review; the safety and efficacy of growth hormone in the healthy elderly, Ann. Intern. Med. 146:104–115.
  654. Liu, H., Ren, J. G., Cooper, W. L., Hawkins, C. E., Cowan, M. R., and Tong, P. Y., 2004, Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site, Proc. Natl. Acad. Sci. USA 101:6605–6610.
  655. Livrea, M. A., Tesoriere, L., Pintaudi, A. M., Calabrese, A., Maggio, A., Freisleben, H. J., D’Arpa, D., D’Anna, R., and Bongiorno, A., 1996, Oxidative stress and antioxidant status in betathalassemia major: iron overload and depletion of lipid-soluble antioxidants, Blood 88:3608– 3614.
  656. Llevadot, J., Murasawa, S., Kureishi, Y., Uchida, S., Masuda, H., Kawamoto, A., Walsh, K., Isner, J. M., and Asahara, T., 2001, HMG-CoA reductase inhibitor mobilizes bone marrow – derived endothelial progenitor cells, J. Clin. Invest. 108:399–405.
  657. Lockwood, A. H., Salvi, R. J., and Burkard, R. F., 2002, Tinnitus, N. Engl. J. Med. 347:904–910.
  658. Loconte, S., 2000, La sindrome fibromialgica primaria, in Proceedings: I Congresso IMOS, Italia, Siena, 2–4 novembre 2000, p. 40.
  659. Loebstein, R., Lehotay, D. C., Luo, X., Bartfay, W., Tyler, B., and Sher, G. D., 1998, Diabetic nephropathy in hypertransfused patients with beta-thalassemia. The role of oxidative stress, Diabetes Care 21:1306–1309.
  660. Long, N. C., Suh, J., Morrow, J. D., Schiestl, R. H., Murthy, G. G., Brain, J. D., and Frei, B., 2001, Ozone causes lipid peroxidation but little antioxidant depletion in exercising and nonexercising hamsters, J. Appl. Physiol. 91:1694–1700.
  661. Loprete, F., 1999, Utilizzo dell’ossigeno-ozonoterapia nel trattamento della malattia varicosa e sue complicanze, in L’Ozonoterapia nel 2000 (F. Ceccherelli, and F. Giron, Eds.), Edizioni Libreria Cortina, Torino, pp. 129–135.
  662. Los, M., Dröge, W., Stricker, K., Baeuerle, P. A., and Schulze-Osthoff, K., 1995, Hydrogen peroxide as a potent activator of T lymphocyte functions, Eur. J. Immunol. 25:159–165.
  663. Love, I. N., 1888, Peroxide of hydrogen as a remedial agent, JAMA 262–265.
  664. Lovell, D. J., Giannini, E. H., Reiff, A., Cawkwell, G. D., Silverman, E. D., Nocton, J. J., Stein, L. D., Gedalia, A., Ilowite, N. T., Wallace, C. A., Whitmore, J., and Finck, B. K., 2000, Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group, N. Engl. J. Med. 342:763–769.
  665. Lusis, A. J., 2000, Atherosclerosis, Nature 407:233–241.
  666. Lynch, E., (Ed.), 2004, The revolution in dentistry. Quintessence Copenhagen Publisher, Copenhagens.
  667. Mach, F., 2003, Statins as novel immunomodulators: from cell to potential clinical benefit, Thromb. Haemost. 90:607–610.
  668. Macular photocoagulation group, 1991, Argon laser photocoagulation for neovascular maculopathy after five years: results for randomized clinical trials, Arch. Ophthalmol. 109: 1109–1114.
  669. Maddox, K., and Back, R. F., 1935, An enquiry into the value of autohaemotherapy in juvenile asthma, Arch. Dis. Child. 10:381–388.
  670. Madej, P., Plewka, A., Madej, J. A. et al., 2007, Ozone therapy in induced endotoxemic shock. II. The effect of Ozone therapy upon selected histochemical reactions on organs of rats in endotoxemic shock, Inflammation 30:69–86.
  671. Maestrelli, P., Paska, C., Saetta, M., Turato, G., Nowicki, Y., Monti, S., Formichi, B., Miniati, M., and Fabbri, L. M., 2003, Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients, Eur. Respir. J. 21:971–976.
  672. Maggio, M., Ceda, G. P., Basaria, S. et al., 2008, Dehydroepiandrosterone sulphate has not been substantiated as an anabolic hormone-reply, Arch. Intern. Med. 168:1470.
  673. Maini, R., St Clair, E. W., Breedveld, F., Furst, D., Kalden, J., Weisman, M., Smolen, J., Emery, P., Harriman, G., Feldmann, M., and Lipsky, P., 1999, Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group, Lancet 354:1932–1939.
  674. Major, E. O., 2009, Reemergence of PML in natalizumab-tretaed patients—new cases, same concerns, N. Engl. J. Med. 361:1041–1043.
  675. Makino, Y., Okamoto, K., Yoshikawa, N., Aoshima, M., Hirota, K., Yodoi, J., Umesono, K., Makino, I., and Tanaka, H., 1996, Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system, J. Clin. Invest. 98:2469–2477.
  676. Mallozzi, C., Di Stasi, A. M., and Minetti, M., 1997, Peroxynitrite modulates tyrosine-dependent signal transduction pathway of human erythrocyte band 3, FASEB J. 11:1281–1290.
  677. Manu, P., 2000, Chronic fatigue syndrome: the fundamentals still apply, Am. J. Med. 108:172– 173.
  678. Marchegiani, F., Marra, M., Olivieri, F. et al., 2008, Paraoxonase 1: genetics and activities during aging, Rejuvenation Res. 11:113–127.
  679. Marin DP1, dos Santos Rde C, Bolin AP, Guerra BA, Hatanaka E, Otton R., 2011, Cytokines and oxidative stress status following a handball game in elite male players, Oxid Med Cell Longev. 2011:804873.
  680. Markesbery, W. R., 1997, Oxidative stress hypothesis in Alzheimer’s disease, Free Radic. Biol. Med. 23:134–147.
  681. Marrades, R. M., Roca, J., Campistol, J. M., Diaz, O., Barbera, J. A., Torregrosa, J. V., Masclans, J. R., Cobos, A., Rodriguez-Roisin, R., and Wagner, P. D., 1996, Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure, J. Clin. Invest. 97:2092–2100.
  682. Martin, P., 1997, Wound healing-aiming for perfect skin regeneration, Science 276:75–81.
  683. Martinez-Sanchez, G., Al-Dalain, S. M., Menendez, S., et al., 2005, Therapeutic efficacy of ozone in patients with diabetic foot. Eur. J. Pharmacol. 523:151–161.
  684. Martindale, W., and Capper, K. T., 1952, The extra pharmacopoeia, The Pharmaceutical Press, London, pp. 1–816.
  685. Masschelein, W. J., 1996, Iodometric method for the determination of ozone in a process gas, in
    Página 89 89
    Revisión WFOT sobre ozonoterapia basada en evidencias
    Ozon-Handbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. 1–3.
  686. Matos, H. R., Di Mascio, P., and Medeiros, M. H., 2000, Protective effect of lycopene on lipid peroxidation and oxidative DNA damage in cell culture, Arch. Biochem. Biophys. 383:56–59.
  687. Matsumoto, A., Sakurai, S., Shinriki, N., Suzuki, S., and Miura, T., 2001, Therapeutic effects of ozonized olive oil in the treatment of intractable fistula and wound after surgical operation, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 77–84.
  688. Mattassi, R., Bassi, P., D’Angelo, F., Franchina, A., and Sbrascini, S., 1985, Ozone as therapy in herpes simplex and herpes zoster diseases, in Medical applications of ozone (J. LaRaus, Ed.), International Ozone Association, Norwalk, CT, pp. 134–137.
  689. Mattassi, R., D’Angelo, F., Bisetti, P., Colombo, R., and Vaghi, M., 1987, Terapia con ozono per via parenterale nelle arteriopatie obliteranti periferiche: meccanismo biochimico e risultati clinici, Il Giornale Di Chirurgia VIII:109–111.
  690. Mattox, D. E., and Simmons, F. B., 1977, Natural history of sudden sensorineural hearing loss, Ann. Otol. Rhinol. Laryngol. 86:463–480.
  691. Mawsouf, N., Tanbouli, T. T., and El-Tayar, W. I., 2004, Ozonetherapy in HCV infection, in OzonHandbuch. Grundlagen Prävention, therapie (R. von Viebahn-Hänsler, and H. G. Knoch, Eds.), Ecomed, Landsberg, in press.
  692. Mayer, R. J., 2004, Two steps forward in the treatment of colorectal cancer, N. Engl. J. Med. 350:2406–2408.
  693. McCall, M. R., and Frei, B., 1999, Can antioxidant vitamins materially reduce oxidative damage in humans? Free Radic. Biol. Med. 26:1034–1053.
  694. McCarey, D. W., McInnes, I. B., Madhok, R., Hampson, R., Scherbakov, O., Ford, I., Capell, H. A., and Sattar, N., 2004, Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial, Lancet 363:2015–2021.
  695. McConnell, R., Berhane, K., Gilliland, F., London, S. J., Islam, T., Gauderman, W. J., Avol, E., Margolis, H. G., and Peters, J. M., 2002a, Asthma in exercising children exposed to ozone: a cohort study, Lancet 359:386–391.
  696. McConnell, R., Berhane, K., Gilliland, F., London, S. J., Islam, T., Gauderman, W. J., Avol, E., Margolis, H. G., and Peters, J. M., 2002b, Asthma in exercising children exposed to ozone: a cohort study, Lancet 359:386–391.
  697. McCord, J. M., 1974, Free radicals and inflammation: protection of synovial fluid by superoxide dismutase, Science 185:529–531.
  698. McCully, K. K., and Natelson, B. H., 1999, Impaired oxygen delivery to muscle in chronic fatigue syndrome, Clin. Sci. (Lond) 97:603–608.
  699. McDonnell, W. F., 1991, Intersubject variability in human acute ozone responsiveness, Pharmacogenetics 1:110–113.
  700. McInnes, I. B., and Liew, F. Y., 1998, Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis, Immunol. Today 19:75–79.
  701. Mecocci, P., Polidori, M. C., Troiano, L., Cherubini, A., Cecchetti, R., Pini, G., Straatman, M., Monti, D., Stahl, W., Sies, H., Franceschi, C., and Senin, U., 2000, Plasma antioxidants and longevity: a study on healthy centenarians, Free Radic. Biol. Med. 28:1243–1248.
  702. Meewes, C., Brenneisen, P., Wenk, J., Kuhr, L., Ma, W., Alikoski, J., Poswig, A., Krieg, T., and Scharffetter-Kochanek, K., 2001, Adaptive antioxidant response protects dermal fibroblasts from UVA- induced phototoxicity, Free Radic. Biol. Med. 30:238–247.
  703. Mellanby, R. J., Thomas, D. C., and Lamb, J., 2009, Role of regulatory T-cells in autoimmunity, Clin. Sci. 116:639–649.
  704. Mellor, A. L., and Munn, D. H., 1999, Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol. Today 20:469–473.
  705. Mendiratta, S., Qu, Z.-C., and May, J. M., 1998a, Erythrocyte ascorbate recycling: antioxidant effects in blood, Free Radic. Biol. Med. 24:789–797.
  706. Mendiratta, S., Qu, Z.-C., and May, J. M., 1998b, Enzyme-dependent ascorbate recycling in human erythrocytes: role of thioredoxin reductase, Free Radic. Biol. Med. 25:221–228.
  707. Menéndez, F., Díaz, G., Menéndez, S., 1989. [Ozone therapy in rheumatoid arthritis]. Rev CENIC Cienc Biol 20, 144–151.
  708. Menendez, S. et al., 1995, Application of ozonized oil in the treatment of infantile giardiasis, in Proceedings Ozone in Medicine. 12th World Congress of the International Ozone Association, Lille, France, 15th–18th May 1995 (International Ozone Association, Ed.), Instaprint S.A., Tours, pp. 297–300.
  709. Menendez, S., Falcon, L., Simon, D. R., and Landa, N., 2002, Efficacy of ozonized sunflower oil in the treatment of tinea pedis, Mycoses 45:329–332.
  710. Menendez, S., Falcon, L., and Maqueira, Y., 2010, Therapeutic efficacy of topically Oleozon in patients suffering from onychomycosis, Mycoses in press. Merz, T., Bender, M. A., Kerr, H. D., and Kulle, T. J., 1975, Observations of aberrations in chromosomes of lymphocytes from human subjects exposed at a concentration of 0.5 ppm for 6 and 10 hours, Mutat. Res. 3:299–302.
  711. Mezey, E., Key, S., Vogelsang, G., Szalayova, I., Lange, G. D., and Crain, B., 2003, Transplanted bone marrow generates new neurons in human brains, Proc. Natl. Acad. Sci. USA 100: 1364–1369.
  712. Micheli, V., Ricci, C., Taddeo, A., and Gili, R., 1985, Centrifugal fractionation of human erythrocytes according to age: comparison between Ficoll and Percoll density gradients, Quad. Sclavo. Diagn 21:236–248.
  713. Miller, D. H., 2003, Commentary: evaluating disease modifying tretments in multiple sclerosis, BMJ 326:525.
  714. Miller, D. H., Khan, O. A., Sheremata, W. A., Blumhardt, L. D., Rice, G. P., Libonati, M. A., Willmer-Hulme, A. J., Dalton, C. M., Miszkiel, K. A., and O’Connor, P. W., 2003, A controlled trial of natalizumab for relapsing multiple sclerosis, N. Engl. J. Med. 348:15–23.
  715. Miller, N. J., Rice-Evans, C., Davies, M. J., Gopinathan, V., and Milner, A., 1993, A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates, Clin. Sci. 84:407–412.
  716. Milligan, N. G., Newcombe, R., and Compston, D. A. S., 1986, A double-blind controlled trial of high-dose methylprednisolone in patients with multiple sclerosis. 1: clinical effects, J. Neurol. Neurosurg. Psychiatry. 50:511–516.
  717. Minetti, M., Mallozzi, C., Di Stasi, A. M. M., and Pietraforte, D., 1998, Bilirubin is an effective antioxidant of peroxynitrite-mediated protein oxidation in human blood plasma, Arch. Biochem. Biophys. 352:165–174.
  718. Minokoshi, Y., Kim, Y. B., Peroni, O. D., Fryer, L. G., Muller, C., Carling, D., and Kahn, B. B., 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature 415:339–343.
  719. Miroshin, S. J., and Kontorshikova, C. N., 1995, The use of ozonetherapy technology in the treatment of modern war surgical trauma, in The ozone in biology and medicine. 2nd All Russian Scientific-Practical Conference, September 6–8, 1995. Russian association of ozonetherapy, Reshetnikovskaya street 2, Nizhni Novgorod, 603006 Russia, p. 16.
  720. Miura, T., Suzuki, S., Sakurai, S., Matsumoto, A., and Shinriki, N., 2001, Structure elucidation of ozonated olive oil, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 72–76.
  721. Miyazono, M., Garat, C., Morris, K. G., Jr., and Carter, E. P., 2002, Decreased renal heme oxygenase-1 expression contributes to decreased renal function during cirrhosis, Am. J. Physiol. Renal. Physiol. 283:F1123–F1131.
  722. Moldofsky, H., Scarisbrick, P., England, R., and Smythe, H. A., 1975, Musculoskeletal symptoms and non-REM sleep disturbance in patients with “Fibrositis Syndrome” and healthy subjects, Psychosom. Med. 37:341–351.
  723. Molina, M. J., and Rowland, F. S., 1974, Stratospheric sink for chlorofluoromethanes: chlorine atom catalyzed destruction of ozone, Nature 249:810–814.
  724. Molinari, F., Simonetti, V., Franzini, M., Pandolfi, S., Vaiano, F., Valdenassi, L., Liboni, W., 2014. Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients. Int J Immunopathol Pharmacol 27, 379–389.
  725. Moncada, S., 1992, Nitric oxide gas: mediator, modulator, and pathophysiologic entity, J. Lab. Clin. Med. 120:187–191.
  726. Morena, M., Cristol, J. P., Bosc, J. Y., Tetta, C., Forret, G., descomps, B., and Canaud, B., 1998, Convective and diffusive losses of vitamin C during hemodiafiltration session: a contributive factor to oxidative stress in hemodialysis patients, Nephrol. Dial. Transplant. 13:A200.
  727. Morena, M., Cristol, J. P., and Canaud, B., 2000, Why hemodialysis patients are in a prooxidant state? What could be done to correct the pro/antioxidant imbalance, Blood Purif. 18: 191–199.
  728. Mori, T. A., Woodman, R. J., Burke, V., Puddey, I. B., Croft, K. D., and Beilin, L. J., 2003, Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated hypertensive type 2 diabetic subjects, Free Radic. Biol. Med. 35:772–781.
  729. Morisco, F., Verde, V., Fogliano, V., Ritieni, A., Marmo, R., De Luise, G., Tuccillo, C., and Caporaso, N., 2004, Oxidative status in chronic hepatitis C: the influence of antiviral therapy and prognostic value of serum hydroperoxide assay, Free Radic. Res. 38:573–58
  730. Morita, T., and Kourembanas, S., 1995, Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide, J. Clin. Invest. 96: 2676–2682.
  731. Morley, J. E., and Perry, H. M., III, 2000, Androgen deficiency in aging men: role of testosterone replacement therapy, J. Lab. Clin. Med. 135:370–378.
  732. Morris, C. R., Kuypers, F. A., Larkin, S., Sweeters, N., Simon, J., Vichinsky, E. P., and Styles, L. A., 2000, Arginine therapy: a novel strategy to induce nitric oxide production in sickle cell disease, Br. J. Haematol. 111:498–500.
  733. Morrow, J. D., and Jackson Roberts, L., 1997, The isoprostanes: unique bioactive products of lipid peroxidation, Prog. Lipid Res. 36:1–21.
  734. Morrow, J. D., Frei, B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W. E., Oates, J. A., and Roberts, L. J., 1995, Increase in circulating products of lipid peroxidation (F2- isoprostanes) in smokers. Smoking as a cause of oxidative damage, N. Engl. J. Med. 332: 1198–1203.
  735. Morsy, M. D., Niazy, W. H., and Zalat, S. I., 2010, Improvement of renal oxidative stress markers after ozone administration in diabetic nephropathy in rats, Diab. Metab. Disord. 2010 in press.
  736. Mosmann, T. R., and Sad, S., 1996, The expanding universe of T-cell subsets: Th1, Th2 and more, Immunol. Today 17:138–146.
  737. Motzer, R. J., Rakhit, A., Thompson, J. A., Nemunaitis, J., Murphy, B. A., Ellerhorst, J., Schwartz, L. H., Berg, W. J., and Bukowski, R. M., 2001, Randomized multicenter phase II trial of subcutaneous recombinant human interleukin-12 versus interferon-alpha 2a for patients with advanced renal cell carcinoma, J. Interferon Cytokine Res. 21:257–263.
  738. Mouitys-Mickalad, A., Deby, C., Deby-Dupont, G., and Lamy, M., 1998, An electron spin resonance (ESR) study on the mechanism of ascorbyl radical production by metal-binding proteins, BioMetals 11:81–88.
  739. Mudd, J. B., Dawson, P. J., and Santrock, J., 1997, Ozone does not react with human erythrocyte membrane lipids, Arch. Biochem. Biophys. 341:251–258.
  740. Muller, W. A., 2002, Leukocyte-endothelial cell interactions in the inflammatory response, Lab. Invest. 82:521–533.
  741. Murai, A., Nakajima, T., and Tahara, N., 2003, Verification of ozone clusters (O6 & O9), Ozone Sci. Eng. 25:211–221.
  742. Murphy, W. J., and Longo, D. L., 2000, Growth hormone as an immunomodulating therapeutic agent, Immunol. Today 21:211–213.
  743. Murry, C. E., Jennings, R. B., and Reimer, K. A., 1986, Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium, Circulation 74:1124–1136.
  744. Murry, C. E., Soonpaa, M. H., Reinecke, H., Nakajima, H., Nakajima, H. O., Rubart, M., Pasumarthi, K. B., Virag, J. I., Bartelmez, S. H., Poppa, V., Bradford, G., Dowell, J. D., Williams, D. A., and Field, L. J., 2004, Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts, Nature 428:664–668.
  745. Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., and Miller, A. H., 2001, Paroxetine for the prevention of depression induced by high-dose interferon alfa, N. Engl. J. Med. 344:961–966.
  746. Nakao, A., Sugimoto, R., Billiar, T. R., and McCurry, K. R., 2009a, Therapeutic antioxidant medical gas, J. Clin. Biochem. Nutr. 44:1–13.
  747. Nakao, A., Faleo, G., Nalesnik, M. A. et al., 2009b, Low-dose carbon monoxide inhibits progressive chronic allograft nephropathy and restores renal allograft function, Am. J. Physiol. Renal Physiol. 297:F19–F26.
  748. Nakao, N., Frodl, E. M., Widner, H., Carlson, E., Eggerding, F. A., Epstein, C. J., and Brundin, P., 1995, Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson’s disease, Nat. Med. 1:226–231.
  749. Natelson, B. H., 2001, Chronic fatigue syndrome, JAMA 285:2557–2559.
  750. Nath, K. A., Haggard, J. J., Croatt, A. J., Grande, J. P., Poss, K. D., and Alam, J., 2000, The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo, Am. J. Pathol. 156:1527–1535.
  751. Nathan, C. F., and Cohn, Z. A., 1981, Antitumor effects of hydrogen peroxide in vivo, J. Exp. Med. 154:1539–1553.
  752. Nathan, C. F., Brukner, L. H., Silverstein, S. C., and Cohn, Z. A., 1979a, Extracellular cytolysis by activated macrophages and granulocytes. I. Pharmacologic triggering of effector cells and the release of hydrogen peroxide, J. Exp. Med. 149:84–99.
  753. Nathan, C. F., Silverstein, S. C., Brukner, L. H., and Cohn, Z. A., 1979b, Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity, J. Exp. Med. 149:100–113.
  754. Nemoto, S., and Finkel, T., 2002, Redox regulation of forkhead proteins through a p66shcdependent signalling pathway, Science 295:2450–2452.
  755. Neuhaus, O., Farina, C., Yassouridis, A., Wiendl, H., Then, B. F., Dose, T., Wekerle, H., and Hohlfeld, R., 2000, Multiple sclerosis: comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells, Proc. Natl. Acad. Sci. USA 97:7452–7457.
  756. Neumann, A. U., Lam, N. P., Dahari, H., Gretch, D. R., Wiley, T. E., Layden, T. J., and Perelson, A. S., 1998, Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-a therapy, Science 282:103–107.
  757. Newsome, D. A., Swartz, M., Leone, N. C., Elston, R. C., and Miller, E., 1988, Oral zinc in macular degeneration, Arch. Ophthalmol. 106:192–198.
  758. Nicolaides, N., 1974, Skin lipids:their biochemical uniqueness, Science 186:19–26.
  759. Nieva, J., and Wentworth, P., Jr., 2004, The antibody-catalyzed water oxidation pathway – a new chemical arm to immune defense? Trends Biochem. Sci. 29:274–278.
  760. Niki, E., 2009, Lipid peroxidation: physiological levels and dual biological effects, Free Radic. Biol. Med. 47:469–484.
  761. Noguchi, P., 2003, Risks and benefits of gene therapy, N. Engl. J. Med. 348:193–194.
  762. Nortvedt, M. W., Riise, T., Myhr, K. M., Nyland, H. I., and Hanestad, B. R., 1999, Type I interferons and the quality of life of multiple sclerosis patients. Results from a clinical trial on interferon alfa-2a, Mult. Scler. 5:317–322.
  763. Noyer, C. M., and Brandt, L. J., 1999, Hyperbaric oxygen therapy for perineal Crohn’s disease, Am. J. Gastroenterol. 94:318–321.
  764. Null, 1996, Ozone: a wide-spectrum realer, Penthouse Mag. January 12.
  765. Oberley, T. D., and Oberley, L. W., 1997, Antioxidant enzyme levels in cancer, Histol. Histopathol. 12(2):525–535.
  766. O’Byrne, P. M., Inman, M. D., and Adelroth, E., 2004, Reassessing the Th2 cytokine basis of asthma, Trends Pharmacol. Sci. 25:244–248.
  767. Oehler, M. K., and Bicknell, R., 2000, The promise of anti-angiogenic cancer therapy, Br. J. Cancer 82:749–752.
  768. O’Farrelly, C., and Crispe, I. N., 1999, Prometheus through the looking glass: reflections on the hepatic immune system, Immunol. Today 20:394–398.
  769. Ohkura, N., and Sakagushi, S., 2009, A novel modifier of regulatory T cells, Nat. Immunol. 10: 685–686.
  770. Okabe, N., 2001, The pathogenesis of Crohn’s disease, Digestion 63(Suppl 1):52–59.
  771. Olin, J. W. 2006. A multicenter, randomized, double-blind, placebo-controlled study of immune modulation therapyin patients with symptomatic peripheral arterial diseases: the SIMPADICO trial. Presented at: Smaller Late-Breaking Clinical Trials I, American College of Cardiology 55th Annual Scientific Sessions, Atlanta, GA, March 11–14.
  772. Olivieri, G., Bodycote, J., and Wolff, S., 1984, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine, Science 223:594–597.
  773. Olivieri, N. F., and Brittenham, G. M., 1997, Iron-chelating therapy and the treatment of thalassemia, Blood 89:739–761.
  774. Olsen, S. J., DeBess, E. E., McGivern, T. E., Marano, N., Eby, T., Mauvais, S., Balan, V. K., Zirnstein, G., Cieslak, P. R., and Angulo, F. J., 2001, A nosocomial outbreak of fluoroquinoloneresistant salmonella infection, N. Engl. J. Med. 344:1572–1579.
  775. Olwin, J. H., Ratajczak, H. V., and House, R. V., 1997, Successful treatment of herpetic infections by autohemotherapy, J. Altern. Complement. Med. 3:155–158.
  776. Onik, G., Maroon, J., Helms, C., Schweigel, J., Mooney, V., Kahanovitz, N., Day, A., Morris, J., McCulloch, J. A., and Reicher, M., 1987, Automated percutaneous discectomy: initial patient experience. Work in progress, Radiology 162:129–132.
  777. O’Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., and Folkman, J., 1997, Endostatin: an endogenous inhibitor of angiogenesis and tumor growth, Cell 88:277–285.
  778. Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A., and Anversa, P., 2001, Mobilized bone marrow cells repair the infarcted heart, improving function and survival, Proc. Natl. Acad. Sci. USA 98:10344–10349.
  779. Orringer, E. P., Casella, J. F., Ataga, K. I., Koshy, M., Adams-Graves, P., Luchtman-Jones, L., Wun, T., Watanabe, M., Shafer, F., Kutlar, A., Abboud, M., Steinberg, M., Adler, B., Swerdlow, P., Terregino, C., Saccente, S., Files, B., Ballas, S., Brown, R., Wojtowicz-Praga, S., and Grindel, J. M., 2001, Purified poloxamer 188 for treatment of acute vaso-occlusive crisis of sickle cell disease: a randomized controlled trial, JAMA 286:2099–2106.
  780. Orta de Velasquez, Ma. T., Rojas, Ma. N., Martìnez, J. L., and Monje, I., 2001, Destruction of helminth eggs (Ascaris suum) by ozone, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 63–71.
  781. Otterbein, L. E., Kolls, J. K., Mantell, L. L., Cook, J. L., Alam, J., and Choi, A. M. K., 1999, Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury, J. Clin. Invest. 103:1047–1054.
  782. Overgaard, J., Gonzalez, G. D., Hulshof, M. C., Arcangeli, G., Dahl, O., Mella, O., and Bentzen, S. M., 1995, Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma. European Society for Hyperthermic Oncology, Lancet 345:540–543.
  783. Owen, C. G., Fletcher, A. E., Donoghue, M., and Rudnicka, A. R., 2003, How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? Br. J. Ophthalmol. 87:312–317.
  784. Packer, L., Roy, S., and Sen, C. K., 1997, Alpha-lipoic acid: a metabolic antioxidant and potential redox modulator of transcription, Adv. Pharmacol. 38:79–101.
  785. Padayatty, S. J., Riordan, H. D., Hewitt, S. M. et al., 2006, Intravenously administered vitamin C as cancer therapy: three cases, CMAJ 174:937–942.
  786. Pamphilon, D., 2000, Viral inactivation of fresh frozen plasma, Br. J. Haematol. 109:680–693.
  787. Pannen, B. H. J., Köhler, N., Hole, B., Bauer, M., Clemens, M. G., and Geiger, K. K., 1998, Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats, J. Clin. Invest. 102:1220–1228.
  788. Pantel, K., Cote, R. J., and Fodstad, Ø., 1999, Detection and clinical importance of micrometastatic disease, J. Natl. Cancer Inst. 91:1113–1124.
  789. Pardo, C. A., Xu, Z., Borchelt, D. R., Price, D. L., Sisodia, S. S., and Cleveland, D. W., 1995, Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons, Proc. Natl. Acad. Sci. USA 92: 954–958.
  790. Parker, A. J., Wessely, S., and Cleare, A. J., 2001, The neuroendocrinology of chronic fatigue syndrome and fibromyalgia, Psychol. Med. 31:1331–1345.
  791. Parks, D. A., and Granger, D. N., 1983, Ischemia-induced vascular changes: role of xanthine oxidase and hydroxyl radicals, Am, J. Physiol. 245:G285–G289.
  792. Parmiani, G., Rodolfo, M., and Melani, C., 2000, Immunological gene therapy with ex vivo genemodified tumor cells: a critique and a reappraisal, Hum. Gene. Ther. 11:1269–1275.
  793. Parola, M., Bellomo, G., Robino, G., Barrera, G., and Dianzani, M. U., 1999, 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications, Antiox. Redox Signal. 1:255–284.
  794. Patterson, C., and Runge, M. S., 2000, Therapeutic myocardial angiogenesis via vascular endothelial growth factor gene therapy: moving on down the road, Circulation 102:940–942.
  795. Pauleikhoff, D., and Koch, J. M., 1995, Prevalence of age-related macular degeneration, Curr. Opin. Ophthalmol. 6:51–56.
  796. Pauleikhoff, D., Barondes, M. J., Minassian, D., Chisholm, I. H., and Bird, A. C., 1990, Drusen as risk factors in age-related macular disease, Am. J. Ophthalmol. 109:38–43.
  797. Paulesu, L., Luzzi, E., and Bocci, V., 1991, Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF-a) on human leucocytes, Lymphokine Cytokine Res. 10:409–412.
  798. Pawliuk, R., Westerman, K. A., Fabry, M. E., Payen, E., Tighe, R., Bouhassira, E. E., Acharya, S. A., Ellis, J., London, I. M., Eaves, C. J., Humphries, R. K., Beuzard, Y., Nagel, R. L., and Leboulch, P., 2001, Correction of sickle cell disease in transgenic mouse models by gene therapy, Science 294:2368–2371.
  799. Payne, L. C., and Krueger, J. M., 1992, Interactions of cytokines with the hypothalamus-pituitary axis, J. Immunother. 12:171–173.
  800. Payr, E., 1935, Über Ozonbehandlung in der Chirurgie, Münch. Med. Wochenschr. 82:220–291.
  801. Pecorelli, A., Bocci, V., Acquaviva, A., Belmonte, G., Gardi, C., Virgili, F., Ciccoli, L., and Valacchi, G., 2013, NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol 267, 30-40
  802. Pembrey, M. E., Bygren, L. O., Kaati, G. et al., 2006, Sex-specific, male-line transgenerational responses in humans, Eur. J. Hum. Genet. 14:159–166.
  803. Peng, J., Jones, G. L., and Watson, K., 2000, Stress proteins as biomarkers of oxidative stress: effects of antioxidant supplements, Free Radic. Biol. Med. 28:1598–1606.
  804. Peralta, C., Leon, O. S., Xaus, C., Prats, N., Jalil, E. C., Planell, E. S., Puig-Parellada, P., Gelpi, E., and Rosello-Catafau, J., 1999, Protective effect of ozone treatment on the injury associated with hepatic ischemia-reperfusion: antioxidant-prooxidant balance, Free Radic. Res. 31:191– 196.
  805. Peralta, C., Xaus, C., Bartrons, R., Leon, O. S., Gelpi, E., and Rosello-Catafau, J., 2000, Effect of ozone treatment on reactive oxygen species and adenosine production during hepatic ischemiareperfusion, Free Radic. Res. 33:595–605.
  806. Perdue, M. H., 1999, Mucosal immunity and inflammation III. The mucosal antigen barrier: cross talk with mucosal cytokines, Am. J. Physiol. 277:G1–G5.
  807. Perletti, G., Concari, P., Giardini, R., Marras, E., Piccinini, F., Folkman, J., and Chen, L., 2000, Antitumor activity of endostatin against carcinogen-induced rat primary mammary tumors, Cancer Res. 60:1793–1796.
  808. Perry, G., Nunomura, A., Hirai, K., Zhu, X., Perez, M., Avila, J., Castellani, R. J., Atwood, C. S., Aliev, G., Sayre, L. M., Takeda, A., and Smith, M. A., 2002, Is oxidative damage the fundamental pathogenic mechanism of Alzheimer’s and other neurodegenerative diseases? Free Radic. Biol. Med. 33:1475–1479.
  809. Petersen, K. F., Oral, E. A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G. W., DePaoli, A. M., Taylor, S. I., Gorden, P., and Shulman, G. I., 2002, Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy, J. Clin. Invest. 109:1345–1350.
  810. Peterson, L. R., 1998, Estrogen replacement therapy and coronary artery disease, Curr. Opin. Cardiol. 13:223–231.
  811. Petralia, B., Tommasini, G., Lavaroni, A., and Fabris, G., 2001, A tutto gas! Il “mal di schiena” curato con l’ozonoterapia, Riv. Neuroradiol. 14:71–73.
  812. Pianko, S., and McHutchison, J., 1999, Chronic hepatitis B: new therapies on the horizon? Lancet 354:1662–1663.
  813. Pickup, J., Mattock, M., and Kerry, S., 2002, Glycaemic control with continuous subcutaneous insulin infusion compared with intensive insulin injections in patients with type 1 diabetes: metaanalysis of randomised controlled trials, BMJ 324:705.
  814. Pierce, G. F., Tarpley, J. E., Tseng, J., Bready, J., Chang, D., Kenney, W. C., Rudolph, R., Robson, M. C., Vande Berg, J., Reid, P., Kaufman, S., and Farrell, C. L., 1995, Detection of plateletderived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds, J. Clin. Invest. 96:1336–1350.
  815. Piguet, B., Palmvang, I. B., Chisholm, I. H., Minassian, D., and Bird, A. C., 1992, Evolution of age-related macular degeneration with choroidal perfusion abnormality, Am. J. Ophthalmol. 113:657–663.
  816. Pippard, M. J., and Weatherall, D. J., 2000, Oral iron chelation therapy for thalassaemia: an uncertain scene, Br. J. Haematol. 111:2–5.
  817. Piroddi, M., Depunzio, I., Calabrese, V., et al., 2007, Oxidatively-modified and glycated proteins as candidate pro-inflammatory toxins in uremia and dialysis patients. Amino Acids 32:573–592.
  818. Pizarro, T. T., Michie, M. H., Bentz, M., Woraratanadharm, J., Smith, M. F., Jr., Foley, E., Moskaluk, C. A., Bickston, S. J., and Cominelli, F., 1999, IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: expression and localization in intestinal mucosal cells, J. Immunol. 162:6829–6835.
  819. Podda, M., Traber, M. G., Weber, C., Yan, L.-J., and Packer, L., 1998, UV-irradiation depletes antioxidants and causes oxidative damage in a model of human skin, Free Radic. Biol. Med. 24:55–65.
  820. Polidori, M. C., Mecocci, P., Levine, M., and Frei, B., 2004, Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation, Arch. Biochem. Biophys. 423:109–115.
  821. Polidori, M. C., Stahl, W., Eichler, O., Niestroj, I., and Sies, H., 2001, Profiles of antioxidants in human plasma, Free Radic. Biol. Med. 30:456–462.
  822. Poli, G., Schaur, R. J., Siems, W. G., and Leonarduzzi, G., 2008, 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest, Med. Res. Rev. 28:569–631.
  823. Polman, C. H., and Uitdehaag, B. M., 2000, Drug treatment of multiple sclerosis, Brit, Med. J. 321:490–494.
  824. Polman, C., Barkhof, F., Kappos, L., Pozzilli, C., Sandbrink, R., Dahlke, F., Jakobs, P., and Lorenz, A., 2003, Oral interferon beta-1a in relapsing-remitting multiple sclerosis: a double-blind randomized study, Mult. Scler. 9:342–348.
  825. Powell, P., Bentall, R. P., Nye, F. J., and Edwards, R. H., 2001, Randomised controlled trial of patient education to encourage graded exercise in chronic fatigue syndrome, BMJ 322: 387– 390.
  826. Prengler, M., Pavlakis, S. G., Prohovnik, I., and Adams, R. J., 2002, Sickle cell disease: the neurological complications, Ann. Neurol. 51:543–552.
  827. Present, D. H., Rutgeerts, P., Targan, S., Hanauer, S. B., Mayer, L., van Hogezand, R. A., Podolsky, D. K., Sands, B. E., Braakman, T., DeWoody, K. L., Schaible, T. F., and van Deventer, S. J. H., 1999, Infliximab for the treatment of fistulas in patients with Crohn’s disease, N. Engl. J. Med. 340:1398–1405.
  828. Prins, J. B., Bleijenberg, G., Bazelmans, E., Elving, L. D., de Boo, T. M., Severens, J. L., van der Wilt, G. J., Spinhoven, P., and van der Meer, J. W., 2001, Cognitive behaviour therapy for chronic fatigue syndrome: a multicentre randomised controlled trial, Lancet 357: 841–847.
  829. Prows, D. R., Shertzer, H. G., Daly, M. J., Sidman, C. L., and Leikauf, G. D., 1997, Genetic analysis of ozone-induced acute lung injury in sensitive and resistant strains of mice, Nat. Genet. 17:471–474.
  830. Pryor, W. A., 1992, How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts? Free Radic. Biol. Med. 12:83–88.
  831. Pryor, W. A., 2000, Vitamin E and heart disease: basic science to clinical intervention trials, Free Radic. Biol. Med. 28:141–164.
  832. Pryor, W. A., Squadrito, G. L., and Friedman, M., 1995, The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products, Free Radic. Biol. Med. 19:935–941.
  833. Pullar, J. M., Vissers, M. C., and Winterbourn, C. C., 2000, Living with a killer: the effects of hypochlorous acid on mammalian cells, IUBMB. Life 50:259–266.
  834. Purasiri, P., Mckechnie, A., Heys, S. D., and Eremin, O., 1997, Modulation in vitro of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids, Immunology 92:166–172.
  835. Puskas, F., Gergely, P., Jr., Banki, K., and Perl, A., 2000, Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C, FASEB J. 14:1352–1361.
  836. Qi, W.-N., and Scully, S. P., 1997, Extracellular collagen modulates the regulation of chondrocytes by transforming growth factor-b1, J. Orthopaed. Res. 15:483–490.
  837. Radu, R. A., Mata, N. L., Nusinowitz, S., Liu, X., Sieving, P. A., and Travis, G. H., 2003, Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt’s macular degeneration, Proc. Natl. Acad. Sci. USA 100:4742–4747.
  838. Rafikova, O., Rafikov, R., and Nudler, E., 2002, Catalysis of S-nitrosothiols formation by serum albumin: the mechanism and implication in vascular control, Proc. Natl. Acad. Sci. USA 99:5913–5918.
  839. Ragab, A., Shreef, E., Behiry, E. et al., 2009, Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss, J. Laryngol. Otol. 123:54–60.
  840. Raghu, G., Brown, K. K., Bradford, W. Z., Starko, K., Noble, P. W., Schwartz, D. A., and King, T. E., Jr., 2004, A placebo-controlled trial of interferon gamma-1b in patients with idiopathic pulmonary fibrosis, N. Engl. J. Med. 350:125–133.
  841. Rahman, I., Clerch, L. B., and Massaro, D., 1991, Rat lung antioxidant enzyme induction by ozone, Am. J. Physiol. 260:L412–L418.
  842. Ranjbar, S., and Holmes, H., 1996, Influence of hydrogen peroxide on the in vitro infectivity of human immunodeficiency virus, Free Radic. Biol. Med. 20:573–577.
  843. Rasmussen, H., Chu, K. W., Campochiaro, P., Gehlbach, P. L., Haller, J. A., Handa, J. T., Nguyen, Q. D., and Sung, J. U., 2001, Clinical protocol. An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD), Hum. Gene. Ther. 12:2029–2032.
  844. Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiss, C., Strauer, B. E., Feelisch, M., and Kelm, M., 2002, Evidence for in vivo transport of bioactive nitric oxide in human plasma, J. Clin. Invest. 109:1241–1248.
  845. Rattan, V., Shen, Y., Sultana, C., Kumar, D., and Kalra, V. K., 1997, Diabetic RBC-induced oxidant stress leads to transendothelial migration of monocyte-like HL-60 cells, Am. J. Physiol. 273:E369–E375.
  846. Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., and Rice-Evans, C., 1999, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic. Biol. Med. 26:1231–1237.
  847. Re, L., Malcangi, G., Mercante, O., Gagliardi, G., Rampoldi, N., 2015, Stevens-Johnson Syndrome Treated with Ozone Hemo Therapy: A Case Report , IJMPCR, 4(4): 92-96
  848. Re L, Martínez-Sánchez G, Bordicchia M, Malcangi G, Pocognoli A, Morales-Segura MA, Rothchild J and Rojas A., 2014, Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result. EJP, 742: 158–162.
  849. Reddy, S. P., Harwood, R. M., Moore, D. F., Grimm, E. A., Murray, J. L., and Vadhan-Raj, S., 1997, Recombinant Interleukin-2 in combination with recombinant interferon-g in patients with advanced malignancy: a phase 1 study, J. Immunother. 20:79–87.
  850. Reeve, V. E., and Tyrrell, R. M., 1999, Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse, Proc. Natl. Acad. Sci. USA 96:9317–9321.
  851. Reichlin, S., 1993, Neuroendocrine-immune interactions, N. Engl. J. Med. 329:1246–1253. Reid, S., Chalder, T., Cleare, A., Hotopf, M., and Wessely, S., 2000, Chronic fatigue syndrome, BMJ 320:292–296.
  852. Reimold, A. M., 2003, New indications for treatment of chronic inflammation by TNF-alpha blockade, Am. J. Med. Sci. 325:75–92.
  853. Reisberg, B., Doody, R., Stoffler, A., Schmitt, F., Ferris, S., and Mobius, H. J., 2003, Memantine in moderate-to-severe Alzheimer’s disease, N. Engl. J. Med. 348:1333–1341.
  854. Reiter, R. J., 1991, Pineal melatonin: cell biology of its synthesis and of its physiological interactions, Endocr. Rev. 12:151–180.
  855. Renaud, B., and Brun-Buisson, C., 2001, Outcomes of primary and catheter-related bacteremia. A cohort and case- control study in critically ill patients, Am. J. Respir. Crit. Care Med. 163: 1584–1590.
  856. Renke, M., Tylicki, L., Rutkowski, P. et al., 2008, The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebocontrolled, randomised, open, cross-over study, Kidney Blood Press Res. 31:404–410.
  857. Resnick, H. E., and Howard, B. V., 2002, Diabetes and cardiovascular disease, Annu. Rev. Med. 53:245–267.
  858. Reth, M., 2002, Hydrogen peroxide as second messenger in lymphocyte activation, Nat. Immunol. 3:1129–1134.
  859. Revel, M., 2003, Interferon-beta in the treatment of relapsing-remitting multiple sclerosis, Pharmacol. Ther. 100:49–62.
  860. Rhee, S. G., Bae, Y. S., Lee, S. R., and Kwon, J., 2000, Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation, Sci. STKE 53:PE1, October 10.
  861. Rice, R. G., 2001, Century 21 – pregnant with ozone, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Volume I (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 1–19.
  862. Rice-Evans, C., and Miller, N. J., 1994, Total antioxidant status in plasma and body fluids, Meth. Enzimol. 234:279–293.
  863. Richards, S. C., and Scott, D. L., 2002, Prescribed exercise in people with fibromyalgia: parallel group randomised controlled trial, BMJ 325:185–188.
  864. Richter, C., Gogvadze, V., Laffranchi, R., Schlapbach, R., Schweizer, M., Suter, M., Walter, P., and Yaffee, M., 1995, Oxidants in mitochondria: from physiology to diseases, Biochim. Biophys. Acta 1271:67–74.
  865. Richter, C., Park, J. W., and Ames, B. N., 1988, Normal oxidative damage to mitochondrial and nuclear DNA is extensive, Proc. Natl. Acad. Sci. USA 85:6465–6467.
  866. Riedemann, N. C., Guo, R. F., and Ward, P. A., 2003, Novel strategies for the treatment of sepsis, Nat. Med. 9:517–524.
  867. Riethmüller, G., Klein, C. A., and Pantel, K., 1999, Hunting down the seminal cells of clinical metastases, Immunol. Today 20:294–296.
  868. Riksen, N. P., Rongen, G. A., Blom, H. J., Russel, F. G., Boers, G. H., and Smits, P., 2003, Potential role for adenosine in the pathogenesis of the vascular complications of hyperhomocysteinemia, Cardiovasc. Res. 59:271–276.
  869. Riva Sanseverino, E., 1989, Knee-joint disorders treated by oxygen-ozone therapy, Eur. Medicophysica 25:163–170.
  870. Riva Sanseverino, E., Meduri, R.A., Pizzino, A., Prantera, M., Martini, E., 1990. Effects of oxygen-ozone therapy on age-related degenerative retinal maculopathy. Panminerva Med 32, 77–84.
  871. Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., and Kehrl, J. H., 1986, Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro, Proc. Natl. Acad. Sci. USA 83:4167–4171.
  872. Roberts, W. C., 1996, The underused miracle drugs: the statin drugs are to atherosclerosis what penicillin was to infectious disease, Am, J. Cardiol. 78:377–378.
  873. Robinson, D., Hamid, Q., Bentley, A., Ying, S., Kay, A. B., and Durham, S. R., 1993, Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma, J. Allergy Clin. Immunol. 92:313–324.
  874. Rocchini, A. P., 2002, Childhood obesity and a diabetes epidemic, N. Engl. J. Med. 346:854– 855.
  875. Rodríguez, M.M., García, J.R., Menendez, S., Devesa, E., Valverde, S., 1998a. [Ozone therapy in the ischemic cerebrovascular disease]. Rev CENIC Cienc Biol 29, 145–148.
  876. Rodríguez, M.M., Menéndez, S., Devesa, E., Gonzáles, R., 1998b. [Ozone therapy in the treatment of senile dementia]. Rev CENIC Cienc Biol 29, 141–144.
  877. Rodríguez, M.M., Menéndez, S., García, J.R., Devesa, E., Cámbara, A., 1998c. [Ozone therapy in the treatment of old patients suffering from Parkinson’s syndromes]. Rev CENIC Cienc Biol 29, 149–152.
  878. Roederer, M., Staal, F. J. T., Raju, P. A., Ela, S. W., Herzenberg Le., A., and Herzenberg L. A., 1990, Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetylLcysteine, Proc. Natl. Acad. Sci. USA 87:4884–4888.
  879. Rokitansky, O., 1982, Klinik und Biochemie der Ozontherapie, Hospitalis 52:643–647.
  880. Rokitansky, O., Rokitansky, A., Steiner, J., Trubel, W., Viebahn, R., and Washüttl, J., 1981, Die Ozontherapie bei peripheren, arteriellen Durchblutungs-störungen; klinik, biochemische und blutgasanalytische Untersuchungen, in Wasser IOA, Ozon-Weltkongress, Berlin, pp. 53–75.
  881. Romero Valdes, A., Menendez Cepero, S., Gomez Moraleda, M., and Ley Pozo, J., 1993, Ozone therapy in the advanced stages of arteriosclerosis obliterans, Angiologia 45: 146–148.
  882. Romero, A. et al., 1988, La ozonoterapia en la aterosclerosis obliterante, CENIC Ciencias Biologicas 20:70–76.
  883. Romero, A. et al., 1993, Arteriosclerosis obliterans and ozone therapy: its administration by different routes, Angiologia 177–179.
  884. Romero, M. J., Bosch-Morell, F., Romero, B., Rodrigo, J. M., Serra, M. A., and Romero, F. J., 1998, Serum malondialdehyde: possible use for the clinical management of chronic hepatitis C patients, Free Radic. Biol. Med. 25:993–997.
  885. Rosa, L., Rosa, E., Sarner, L., and Barrett, S., 1998, A close look at therapeutic touch, JAMA 279:1005–1010.
  886. Rosen, L. S., 2001, Angiogenesis inhibition in solid tumors, Cancer J. 7(suppl 3):S120–S128.
  887. Rosen, P., Nawroth, P. P., King, G., Moller, W., Tritschler, H. J., and Packer, L., 2001, The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society, Diab. Metab. Res. Rev. 17:189–212.
  888. Rosenberg, G. A., 1999, Ischemic brain edema, Prog. Cardiovasc. Dis. 42:209–216.
  889. Rosenberg, S. A., 2001, Progress in human tumour immunology and immunotherapy, Nature 411:380–384.
  890. Rosenberg, S. A., Lotze, M. T., Muul, L. M., Chang, A. E., Avis, F. P., Leitman, S., Linehan, W. M., Robertson, C. N., Lee, R. E., Rubin, J. T., Seipp, C. A., Simpson, C. G., and White, D. E., 1987, A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone, N. Engl. J. Med. 316:889–897.
  891. Rossio, J. L., and Goldstein, A. L., 1977, Immunotherapy of cancer with thymosin, World J. Surg. 1:605–616.
  892. Roth, J. A., and Cristiano, R. J., 1997, Gene therapy for cancer: what have we done and where are we going? J. Natl. Cancer Inst. 89:21–39.
  893. Rotilio, G., 2001, Risk from exposure to metals: deficits and excesses (Cu, Fe, Mn, Al, Cr, B), in Nutrition and Brain (J. D. Fernstrom, R. Uauy, and P. Arroyo, Eds.), Karger AG, Basel, pp. 247– 262.
  894. Rotilio, G., Carri, M. T., Rossi, L., and Ciriolo, M. R., 2000, Copper-dependent oxidative stress and neurodegeneration, IUBMB Life 50:309–314.
  895. Rousseau, Y., Haeffner-Cavaillon, N., Poignet, J. L., Meyrier, A., and Carreno, M. P., 2000, In vivo intracellular cytokine production by leukocytes during haemodialysis, Cytokine 12:506–517.
  896. Rowland, L. P., and Shneider, N. A., 2001, Amyotrophic lateral sclerosis, N. Engl. J. Med. 344:1688–1700.
  897. Rowland, M., 2000, Transmission of Helicobacter pylori: is it all child’s play? Lancet 355: 332– 333.
  898. Rubartelli, A., Poggi, A., Sitia, R., and Zocchi, M. R., 1999, HIV-1 Tat: a polypeptide for all seasons, Immunol. Today 19:543–545.
  899. Rubin, P., Hanley, J., Keys, H. M., Marcial, V., and Brady, L., 1979, Carbogen breathing during radiation therapy-the Radiation Therapy Oncology Group Study, Int. J. Radiat. Oncol. Biol. Phys. 5:1963–1970.
  900. Rudick, R. A., Cohen, J. A., Weinstock-Guttman, B., Kinkel, R. P., and Ransohoff, R. M., 1997, Management of multiple sclerosis, N. Engl. J. Med. 337:1604–1611.
  901. Rudikoff, D., and Lebwohl, M., 1998, Atopic dermatitis, Lancet 351:1715–1721.
  902. Rudman, D., Feller, A. G., Nagraj, H. S., Gergans, G. A., Lalitha, P. Y., Goldberg, A. F., Schlenker, R. A., Cohn, L., Rudman, I. W., and Mattson, D. E., 1990, Effects of human growth hormone in men over 60 years old, N. Engl. J. Med. 323:1–6.
  903. Ruidavets, J. B., Cournot, M., Cassadou, S. et al., 2005, Ozone air pollution is associated with acute myocardial infarction, Circulation 111:563–569.
  904. Ruggenenti, P., Schieppati, A., and Remuzzi, G., 2001, Progression, remission, regression of chronic renal diseases, Lancet 357:1601–1608.
  905. Ruiz, L., Carcelain, G., Martinez-Picado, J., Frost, S., Marfil, S., Paredes, R., Romeu, J., Ferrer, E., Morales-Lopetegi, K., Autran, B., and Clotet, B., 2001, HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection, AIDS 15:F19–F27.
  906. Ryan, H. E., Lo, J., and Johnson, R. S., 1998, HIF-1 alpha is required for solid tumor formation and embryonic vascularization, EMBO J. 17:3005–3015.
  907. Ryter, S. W., Choi, A. M., 2009, Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy. Am. J. Respir. Cell Mol. Biol. 41:251–260.
  908. Ryter, S. W., and Tyrrell, R. M., 2000, The heme synthesis and degradation pathways: role in oxidant sensitivity. Heme oxygenase has both pro- and antioxidant properties, Free Radic. Biol. Med. 28:289–309.
  909. Sagara, Y., Dargusch, R., Chambers, D., Davis, J., Schubert, D., and Maher, P., 1998, Cellular mechanisms of resistance to chronic oxidative stress, Free Radic. Biol. Med. 24:1375–1389.
  910. Sakagushi, S., Yamagushi, T., Nomura, T., and Ono, M., 2008, Regulatory T cells and immune tolerance, Cell 133:775–787.
  911. Saliou, C., Kitazawa, M., McLaughlin, L., Yang, J. P., Lodge, J. K., Tetsuka, T., Iwasaki, K., Cillard, J., Okamoto, T., and Packer, L., 1999, Antioxidants modulate acute solar ultraviolet radiation-induced NF- kappa-B activation in a human keratinocyte cell line, Free Radic. Biol. Med. 26:174–183.
  912. Salvioli, S., Capri, M., Santoro, A. et al., 2008, The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians, Biotechnol. J. 3:740–749.
  913. Samanta, A., and Beardsley, J., 1999, Low back pain: which is the best way forward? BMJ 318:1122–1123.
  914. Sanchez, G. M., Al Dalain, S., Menendez, S. et al., 2005, Therapeutic efficacy of ozone in patients with diabetic foot, Eur. J. Pharmacol. 523:151–161.
  915. Sands, B. E., Anderson, F. H., Bernstein, C. N., Chey, W. Y., Feagan, B. G., Fedorak, R. N., Kamm, M. A., Korzenik, J. R., Lashner, B. A., Onken, J. E., Rachmilewitz, D., Rutgeerts, P., Wild, G., Wolf, D. C., Marsters, P. A., Travers, S. B., Blank, M. A., and van Deventer, S. J., 2004, Infliximab maintenance therapy for fistulizing Crohn’s disease, N. Engl. J. Med. 350: 876–885.
  916. Saran, M., Beck-Speier, I., Fellerhoff, B., and Bauer, G., 1999, Phagocytic killing of microorganisms by radical processes: consequences of the reaction of hydroxyl radicals with chloride yielding chlorine atoms, Free Radic. Biol. Med. 26:482–490.
  917. Sardina, J. O. et al., 1991, Tratamiento de la giardiasis recidivante con ozono, CENIC Ciencias Biologicas 20:61–64.
  918. Sarks, J. P., Sarks, S. H., and Killingsworth, M. C., 1988, Evolution of geographic atrophy of the retinal pigment epithelium, Eye 2(Pt 5):552–577.
  919. Sarnesto, A., Linder, N., and Raivio, K. O., 1996, Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein, Lab. Invest. 74:48–56.
  920. Sartor, R. B., 2000, New therapeutic approaches to Crohn’s disease, N. Engl. J. Med. 342: 1664–1666.
  921. Sasaki, H., Wakutani, T., Oda, S., and Yamasaki, Y., 1967, Application of hydrogen peroxide infusion to maxillary cancer, Yonago Acta Med. 11:141–149.
  922. Sastre, J., Pallardo, F. V., and Vina, J., 2003, The role of mitochondrial oxidative stress in aging, Free Radic. Biol. Med. 35:1–8.
  923. Sato, K., Balla, J., Otterbein, L., Smith, R. N., Brouard, S., Lin, Y., Csizmadia, E., Sevigny, J., Robson, S. C., Vercellotti, G., Choi, A. M., Bach, F. H., and Soares, M. P., 2001, Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants, J. Immunol. 166:4185–4194.
  924. Sato, Y., Sato, K., and Suzuki, Y., 1999, Mechanisms of free radical-induced hemolysis of human erythrocytes: comparison of calculated rate constants for hemolysis with experimental rate constants, Arch. Biochem. Biophys. 366:61–69.
  925. Schmid, P., Cox, D., Bilbe, G., McMaster, G., Morrison, C., Stähelin, H., Lüscher, N., and Seiler, W., 1993, TGF-bs and TGF-b type II receptor in human epidermis: differential expression in acute and chronic skin wounds, J. Pathol. 171:191–197.
  926. Schreiber, S., Heinig, T., Thiele, H. G., and Raedler, A., 1995, Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease, Gastroenterology 108:1434–1444.
  927. Schrope, M., 2000, Successes in fight to save ozone layer could close holes by 2050, Nature 408:627.
  928. Schultze, H. E., and Heremans, J. F., 1966, Molecular biology of human proteins, Volume 1, Elsevier, Amsterdam, p. 473.
  929. Schulz, S., 1986, The role of ozone/oxygen in clindamycin-associated enterocolitis in the Djungarian hamster (Phodopus sungorus sungorus), Lab. Anim. 20:41–48.
  930. Schulz, S., Haussler, U., Mandic, R. et al., 2008, Treatment with ozone/oxygenpneumoperitoneum results in complete remission of rabbit squamous cell carcinomas, Int. J. Cancer 122: 2360–2367.
  931. Schwartz, R. S., and Curfman, G. D., 2002, Can the heart repair itself? N. Engl. J. Med. 346:2– 4.
  932. Schwarz, K. B., 1996, Oxidative stress during viral infection: a review, Free Radic. Biol. Med. 21:641–649.
  933. Scott, M. D., van den Berg, J. J., Repka, T., Rouyer-Fessard, P., Hebbel, R. P., Beuzard, Y., and Lubin, B. H., 1993, Effect of excess alpha-hemoglobin chains on cellular and membrane oxidation in model beta-thalassemic erythrocytes, J. Clin. Invest. 91:1706–1712.
  934. Sechi, L. A., Lezcano, I., Nunez, N., Espim, M., Dupre, I., Pinna, A., Molicotti, P., Fadda, G., and Zanetti, S., 2001, Antibacterial activity of ozonized sunflower oil (Oleozon), J. Appl. Microbiol. 90:279–284.
  935. Seddon, J. M., Ajani, U. A., Sperduto, R. D., Hiller, R., Blair, N., Burton, T. C., Farber, M. D., Gragoudas, E. S., Haller, J., and Miller, D. T., 1994, Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group, JAMA 272:1413–1420.
  936. Seddon, J. M., Gensler, G., Milton, R. C., Klein, M. L., and Rifai, N., 2004, Association between C-reactive protein and age-related macular degeneration, JAMA 291:704–710.
  937. Seeman, T. E., and Robbins, R. J., 1994, Aging and hypothalamic-pituitary-adrenal response to challenge in humans, Endocr. Rev. 15:233–260.
  938. Seifried, H. E., McDonald, S. S., Anderson, D. E., Greenwald, P., and Milner, J. A., 2003, The antioxidant conundrum in cancer, Cancer Res. 63:4295–4298.
  939. Sega, A., Zanardi, I., Chiasserini, L. et al., 2010, Properties of sesame oil by detailed (1)H and (13) C NMR assignments before and after ozonation and their correlation with iodine value, peroxide value and viscosity measurements, Chem. Phys. Lipids 163:148–156.
  940. Seixas, E., Gozzelino, R., Chora, A., et al., 2009, Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc. Natl. Acad. Sci. USA 106:15837–15842.
  941. Semenza, G. L., 2001, Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology, Trends Mol. Med. 7:345–350.
  942. Semenza, G. L., 2003, Targeting HIF-1 for cancer therapy, Nat. Rev. Cancer 3:721–732.
  943. Servaes, P., Verhagen, C., and Bleijenberg, G., 2002, Fatigue in cancer patients during and after treatment: prevalence, correlates and interventions, Eur. J. Cancer 38:27–43.
  944. Shanahan, F., 2002, Crohn’s disease, Lancet 359:62–69.
  945. Sharma, Y. K., and Davis, K. R., 1997, The effects of ozone on antioxidant responses in plants, Free Radic. Biol. Med. 23:480–488.
  946. Sharpe, M. C., Archard, L. C., Banatvala, J. E., Borysiewicz, L. K., Clare, A. W., David, A., Edwards, R. H., Hawton, K. E., Lambert, H. P., Lane, R. J. et al., 1991, A report – chronic fatigue syndrome: guidelines for research, J. R. Soc. Med. 84:118–121.
  947. Shaschova, N. M., Kachalina, T. S., and Nevmjatullin, A. L., 1995, Application of ozonotherapy in complex treatment of inner female genital inflammatory diseases, in Proceedings Ozone in Medicine, 12th World Congress of the International Ozone Association, Lille France, 15th–18th May 1995 (International Ozone Association, Ed.), Instaprint S.A., Tours, pp. 145–155.
  948. Sheldon, T., 2004, Netherlands to crack down on complementary medicine, BMJ 328:485.
  949. Shiba, M., Tadokoro, K., Sawanobori, M., Nakajima, K., Suzuki, K., and Juji, T., 1997, Activation of the contact system by filtration of platelet concentrates with a negatively charged white cellremoval filter and measurement of venous blood bradykinin level in patients who received filtered platelets, Transfusion 37:457–462.
  950. Shinriki, N., Ishizaki, K., Yoshizaki, T., Miura, K., and Ueda, T., 1988, Mechanism of inactivation of tobacco mosaic virus with ozone, Wat. Res. 22:933–938.
  951. Shinriki, N., Suzuki, T., Takama, K., Fukunaga, K., Ohgiya, S., Kubota, K., and Miura, T., 1998, Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone, Haematologia 29:229–239.
  952. Shiomori, T., Miyamoto, H., and Makishima, K., 2001, Significance of airborne transmission of methicillin-resistant Staphylococcus aureus in an otolaryngology-head and neck surgery unit, Arch. Otolaryngol. Head Neck Surg. 127:644–648.
  953. Shiozawa, A., 2000, Characterization of reactive oxygen species generated from the mixture of NaClO and H2 O2 used as root canal irrigants. J. Endod. 26:11–15.
  954. Shull, S., Heintz, N. H., Periasamy, M., Manohar, M., Janssen, Y. M. W., Marsh, J. P., and Mossman, B. T., 1991, Differential regulation of antioxidant enzymes in response to oxidants, J. Biol. Chem. 266:24398–24403.
  955. Siemann, D. W., Hill, R. P., and Bush, R. S., 1977, The importance of the pre-irradiation breathing times of oxygen and carbogen (5% CO2: 95% O2) on the in vivo radiation response of a murine sarcoma, Int. J. Radiat. Oncol. Biol. Phys. 2:903–911.
  956. Siemann, D. W., Horsman, M. R., and Chaplin, D. J., 1994, The radiation response of KHT sarcoma following nicotinamide treatment and carbogen breathing, Radiother. Oncol. 31:117– 122.
  957. Siemsen, C.-H., 1995, Ozon-Anwendung bei akuten und chronischen Gelenkerkrankungen, in Ozon-Handbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. V-9.2 1–V-9.2 14.
  958. Siems, W., and Grune, T., 2003, Intracellular metabolism of 4-hydroxynonenal, Mol. Aspects Med. 24:167–175.
  959. Singh RL, Singh RK, Tripathi AK, Gupta N, Kumar A, Singh AK, Mahdi AA, Prasad R, Singh RK., 2004, Circadian periodicity of plasma lipid peroxides and anti-oxidant enzymes in pulmonary tuberculosis, Indian J Clin Biochem.,Jan;19(1):14-20.
  960. Silver, F. H., and Glasgold, A. I., 1995, Cartilage wound healing. An overview, Otolaryngol. Clin. N. Am. 28:847–864.
  961. Simonian, N. A., and Coyle, J. T., 1996, Oxidative stress in neurodegenerative diseases, Annu. Rev. Pharmacol. Toxicol. 36:83–106.
  962. Sinclair, D. A., 2005, Toward a unified theory of caloric restriction and longevity regulation, Mech. Ageing Dev. 126:987–1002.
  963. Sirito, M. A., 2006, Oxygen-ozone therapy for local adipose deposits and oedematous fibrosclerotic panniculopathy. Riv. It Ossigeno Ozonoterapia 5:37–40.
  964. Slavin, J., 1996, The role of cytokines in wound healing, J. Pathol. 178:5–10.
  965. Sliwa, K., and Ansari, A. A., 2008, Immunosuppression as therapy for congestive heart failure, Lancet 371:184–186.
  966. Slonim, A. D., and Singh, N., 2001, Nosocomial bloodstream infection and cost, Crit. Care Med. 29:1849.
  967. Slonim, A. E., Bulone, L., Damore, M. B., Goldberg, T., Wingertzahn, M. A., and McKinley, M. J., 2000, A preliminary study of growth hormone therapy for Crohn’s disease, N. Engl. J. Med. 342:1633–1637.
  968. Small, D. L., Morley, P., and Buchan, A. M., 1999, Biology of ischemic cerebral cell death, Prog. Cardiovasc. Dis. 42:185–207.
  969. Smith, L. J., Shamsuddin, M., Sporn, P. H., Denenberg, M., and Anderson, J., 1997, Reduced superoxide dismutase in lung cells of patients with asthma, Free Radic. Biol. Med. 22: 1301– 1307.
  970. Smith, L., 1969, Chemonucleolysis, Clin. Orthop. 67:72.
  971. Snyder, S. H., and Baranano, D. E., 2001, Heme oxygenase: a font of multiple messengers, Neuropsychopharmacology 25:294–298.
  972. Soares, C., 2004, Body building, Sci. Am. 290(20):22.
  973. Sohal, R. S., Mockett, R. J., and Orr, W. C., 2002, Mechanisms of aging: an appraisal of the oxidative stress hypothesis, Free Radic. Biol. Med. 33:575–586.
  974. Soholm, B., 1998, Clinical improvement of memory and other cognitive functions by Ginkgo biloba: review of relevant literature, Adv. Ther. 15:54–65.
  975. Song, C. W., Hasegawa, T., Kwon, H. C., Lyons, J. C., and Levitt, S. H., 1992, Increase in tumor oxygenation and radiosensitivity caused by pentoxifylline, Radiat. Res. 130:205–210.
  976. Song, C. W., Lee, I., Hasegawa, T., Rhee, J. G., and Levitt, S. H., 1987, Increase in pO2 and radiosensitivity of tumors by Fluosol-DA (20%) and carbogen, Cancer Res. 47:442–446.
  977. Song, C. W., Shakil, A., Griffin, R. J., and Okajima, K., 1997, Improvement of tumor oxygenation status by mild temperature hyperthermia alone or in combination with carbogen, Semin. Oncol. 24:626–632.
  978. Song, C. W., Shakil, A., Osborn, J. L., and Iwata, K., 1996, Tumour oxygenation is increased by hyperthermia at mild temperatures, Int. J. Hyperthermia 12:367–373.
  979. Sorensen, P. S., Ross, C., Clemmesen, K. M., Bendtzen, K., Frederiksen, J. L., Jensen, K., Kristensen, O., Petersen, T., Rasmussen, S., Ravnborg, M., Stenager, E., and Koch-Henriksen, N., 2003, Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis, Lancet 362:1184–1191.
  980. Spencer, F. A., Allegrone, J., Goldberg, R. J., Gore, J. M., Fox, K. A., Granger, C. B., Mehta, R. H., and Brieger, D., 2004, Association of statin therapy with outcomes of acute coronary syndromes: the GRACE study, Ann. Intern. Med. 140:857–866.
  981. Sperduto, R. D., Ferris, F. L., I., and Kurinij, N., 1990a, Do we have a nutritional treatment for age-related macular degeneration? Arch. Ophthalmol. 108:1403–1405.
  982. Sperduto, R. D., Ferris, F. L., III, and Kurinij, N., 1990b, Do we have a nutritional treatment for age-related cataract or macular degeneration? Arch. Ophthalmol. 108:1403–1405.
  983. Sporn, M. B., and Roberts, A. B., 1993, A major advance in the use of growth factors to enhance wound healing, J. Clin. Invest. 92:2565–2566.
  984. Stadlbauer, T. H. W., Eisele, A., Heidt, M. C. et al., 2008, Preconditioning with ozone abrogates acute rejection and prolongs cardiac allograft survival in rats, Transplant. Proc. 40:974–977.
  985. Stadtman, E. R., and Oliver, C. N., 1991, Metal-catalyzed oxidation of proteins. Physiological consequences, J. Biol. Chem. 266:2005–2008.
  986. Stamler, J. S., 2004, S-nitrosothiols in the blood: roles, amounts, and methods of analysis, Circ. Res. 94:414–417.
  987. Stamler, J. S., Singel, D. J., and Loscalzo, J., 1992, Biochemistry of nitric oxide and its redoxactivated forms, Science 258:1898–1902.
  988. Stamm, C., Westphal, B., Kleine, H. D., Petzsch, M., Kittner, C., Klinge, H., Schumichen, C., Nienaber, C. A., Freund, M., and Steinhoff, G., 2003, Autologous bone-marrow stem-cell transplantation for myocardial regeneration, Lancet 361:45–46.
  989. Stasi, R., Abriani, L., Beccaglia, P., Terzoli, E., and Amadori, S., 2003, Cancer-related fatigue: evolving concepts in evaluation and treatment, Cancer 98:1786–1801.
  990. Steece-Collier, K., Maries, E., and Kordower, J. H., 2002, Etiology of Parkinson’s disease: genetics and environment revisited, Proc. Natl. Acad. Sci. USA 99:13972–13974.
  991. Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., and Remaut, E., 2000, Treatment of murine colitis by Lactococcus lactis secreting interleukin-10, Science 289:1352–1355.
  992. Stein, J. L., and Schwartzbrod, J. K., 1990, Experimental contamination of vegetables with helminth eggs, Wat. Sci. Tech. 22:51–57.
  993. Steinberg, M. H., 1999, Management of sickle cell disease, N. Engl. J. Med. 340:1021–1030.
  994. Steinhart, H., Schulz, S., and Mutters, R., 1999, Evaluation of ozonated oxygen in an experimental animal model of osteomyelitis as a further treatment option for skull-base osteomyelitis, Eur. Arch. Otorhinolaryngol. 256:153–157.
  995. Stephan, F., Cheffi, A., and Bonnet, F., 2001, Nosocomial infections and outcome of critically ill elderly patients after surgery, Anesthesiology 94:407–414.
  996. Steuer-Vogt, M. K., Bonkowsky, V., Ambrosch, P., Scholz, M., Neiss, A., Strutz, J., Hennig, M., Lenarz, T., and Arnold, W., 2001, The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial, Eur. J. Cancer 37:23–31.
  997. Stiller, B., Sonntag, J., Dahnert, I., Alexi-Meskishvili, V., Hetzer, R., Fischer, T., and Lange, P. E., 2001, Capillary leak syndrome in children who undergo cardiopulmonary bypass: clinical outcome in comparison with complement activation and C1 inhibitor, Intensive Care Med. 27:193–200.
  998. Stockley, R. A., Mannino, D., and Barnes, P. J., 2009, Burden and pathogenesis of COPD, Proc. Am. Thorac. Soc. 6:524–526.
  999. Stone, J. R., and Collins, T., 2002, The role of hydrogen peroxide in endothelial proliferative responses, Endothelium 9:231–238.
  1000. Stone, J. R., and Yang, S., 2006, Hydrogen peroxide: a signalling messenger, Antioxid. Redox Signal 8:243–270.
  1001. Stover, B. H., Shulman, S. T., Bratcher, D. F., Brady, M. T., Levine, G. L., and Jarvis, W. R., 2001, Nosocomial infection rates in US children’s hospitals’ neonatal and pediatric intensive care units, Am. J. Infect. Control 29:152–157.
  1002. Strauer, B. E., and Kornowski, R., 2003, Stem cell therapy in perspective, Circulation 107: 929– 934.
  1003. Strauer, B. E., Brehm, M., Zeus, T., Gattermann, N., Hernandez, A., Sorg, R. V., Kogler, G., and Wernet, P., 2001, Intracoronary, human autologous stem cell transplantation for myocardial regeneration following myocardial infarction, Dtsch. Med. Wochenschr 126:932–938.
  1004. Stewart, S. T., Cutler, D. M., and Rosen, A. B., 2009, Forecasting the effects of obesity and smoking on US life expectancy, N. Engl. J. Med. 361:2252–2260.
  1005. Stocco, D. M., and McPhaul, M., 2006, Physiology of testicular steroidogenesis, in Physiology of Reproduction (3rd Ed.) (J. D. Neill, Ed.), Elsevier, San Diego, CA:977–1016.
  1006. Su, W. Y., and Gordon, T., 1997, In vivo exposure to ozone produces an increase in a 72-kDa heat shock protein in guinea pigs, J. Appl. Physiol. 83:707–711.
  1007. Subarsky, P., and Hill, R. P., 2003, The hypoxic tumour microenvironment and metastatic progression, Clin. Exp. Metastasis 20:237–250.
  1008. Suckfull, M., 2002, Fibrinogen and LDL apheresis in treatment of sudden hearing loss: a randomised multicentre trial, Lancet 360:1811–1817.
  1009. Suhadolnik, R. J., Peterson, D. L., O’Brien, K., Cheney, P. R., Herst, C. V., Reichenbach, N. L., Kon, N., Horvath, S. E., Iacono, K. T., Adelson, M. E., De Meirleir, K., De Becker, P., Charubala, R., and Pfleiderer, W., 1997, Biochemical evidence for a novel low molecular weight 2-5Adependent RNase L in chronic fatigue syndrome, J. Interferon Cytokine Res. 17:377–385.
  1010. Sun, J. S., Lu, F. J., Huang, W. C., Hou, S. M., Tsuang, Y. H., and Hang, Y. S., 1999,
  1011. Antioxidant status following acute ischemic limb injury: a rabbit model, Free Radic. Res. 31:9– 21.
  1012. Swartz, M. N., 1988, The chronic fatigue syndrome – one entity or many? N. Engl. J. Med. 319:1726–1728.
  1013. Sweet, F., Kao, M.-S., Lee, S.-C. D., Hagar, W. L., and Sweet, W. E., 1980, Ozone selectively inhibits growth of human cancer cells, Science 209:931–933.
  1014. Symons, M. C., Rusakiewicz, S., Rees, R. C., and Ahmad, S. I., 2001, Hydrogen peroxide: a potent cytotoxic agent effective in causing cellular damage and used in the possible treatment for certain tumours, Med. Hypotheses 57:56–58.
  1015. Szatrowski, T. P., and Nathan, C. F., 1991, Production of large amounts of hydrogen peroxide by human tumor cells, Cancer Res. 51:794–798.
  1016. Tabaracci, G., 2001, L’ozonoterapia con tecnica “classica” intramuscolo paravertebrale, Riv. Neuroradiol. 14:67–70.
  1017. Tacchini, L., Pogliaghi, G., Radice, L., Bernelli-Zazzera, A., and Cairo, G., 1996, Posttranscriptional control of increased hepatic catalase gene expression in response to oxidative stress, Redox Report 2:273–278.
  1018. Taga, K., Mostowski, H., and Tosato, G., 1993, Human interleukin-10 can directly inhibit T-cell growth, Blood 81:2964–2971.
  1019. Tamura, Y., Peng, P., Liu, K., Daou, M., and Srivastava, P. K., 1997, Immunotherapy of tumors with autologous tumor-derived heat shock protein preparations, Science 278:117–120.
  1020. Tan, S., Yokoyama, Y., Dickens, E., Cash, T. G., Freeman, B. A., and Parks, D. A., 1993, Xanthine oxidase activity in the circulation of rats following hemorrhagic shock, Free Radic. Biol. Med. 15:407–414.
  1021. Tarkington, B. K., Duvall, T. R., and Last, J. A., 1994, Ozone exposure of cultured cells and tissues, Meth. Enzymol. 234:257–265.
  1022. Tateishi-Yuyama, E., Matsubara, H., Murohara, T., Ikeda, U., Shintani, S., Masaki, H., Amano, K., Kishimoto, Y., Yoshimoto, K., Akashi, H., Shimada, K., Iwasaka, T., and Imaizumi, T., 2002, Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial, Lancet 360:427–435.
  1023. Taylor, R. S., Belli, A. M., and Jacob, S., 1999, Distal venous arterialisation for salvage of critically ischaemic inoperable limbs, Lancet 354:1962–1965.
  1024. Teicher, B. A., Rose, C. M., 1984, Perfluorochemical emulsions can increase tumor radiosensitivity. Science 223:934–936.
  1025. Tepel, M., van der, G. M., Statz, M., Jankowski, J., and Zidek, W., 2003, The antioxidant acetylcysteine reduces cardiovascular events in patients with end-stage renal failure: a randomized, controlled trial, Circulation 107:992–995.
  1026. Thiele, J. J., Traber, M. G., Tsang, K., Cross, C. E., and Packer, L., 1997a, In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine skin, Free Radic. Biol. Med. 23:385–391.
  1027. Thiele, J. J., Traber, M. T., Podda, M., Tsang, K., Cross, C. E., and Packer, L., 1997b, Ozone depletes tocopherols and tocotrienols topically applied to murine skin, FEBS Lett 401: 167–170.
  1028. Thomas, J. A., Darby, T. D., Wallin, R. F., Garvin, P. J., and Martis, L., 1978, A review of the biological effects of di-(2-ethylhexyl) phthalate, Toxicol. Appl. Pharmacol. 45:1–27.
  1029. Thomas, T., Thomas, G., McLendon, C., Sutton, T., and Mullan, M., 1996, Beta-Amyloidmediated vasoactivity and vascular endothelial damage, Nature 380:168–171.
  1030. Thomson, A. J., Webb, D. J., Maxwell, S. R., and Grant, I. S., 2002, Oxygen therapy in acute medical care, BMJ 324:1406–1407.
  1031. Thorburn, A. N., and Hansbro, P. M., 2010, Harnessing regulatory T cells to suppress asthma: from potential to therapy, Am. J. Respir. Cell Mol. Biol. in press.
  1032. Tibbles, P. M., and Edelsberg, J. S., 1996, Hyperbaric-oxygen therapy, N. Engl. J. Med. 334: 1642–1648.
  1033. Ting, H. H., Timimi, F. K., Boles, K. S., Creager, S. J., Ganz, P., and Creager, M. A., 1996, Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus, J. Clin. Invest. 97:22–28.
  1034. Tisdale, M. J., 2002, Cachexia in cancer patients, Nat. Rev. Cancer 2:862–871.
  1035. Titheradge, M. A., 1999, Nitric oxide in septic shock, Biochim. Biophys. Acta 1411:437–455.
  1036. Topol, E. J., 2004, Intensive statin therapy – a sea change in cardiovascular prevention, N. Engl. J. Med. 350:1562–1564.
  1037. Torre-Amione, G., Anker, S. D., Bourge, R. C. et al., 2008, Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM trial): a placebo-controlled randomised trial, Lancet 371:228–236.
  1038. Torre-Amione, G., Sestier, F., Radovancevic, B., and Young, J., 2004, Effects of a novel immune modulation therapy in patients with advanced chronic heart failure: results of a randomized, controlled, phase II trial, J. Am. Coll. Cardiol. 44:1181–1186.
  1039. Torri, G., Della Grazia, A., and Casadei, C., 1999, Clinical experience in the treatment of lumbar disk disease, with a cycle of lumbar muscle injections of an oxygen + ozone mixture, Int. J. Med. Biol. Environ. 27:177–183.
  1040. Tosetti, F., Ferrari, N., De Flora, S., and Albini, A., 2002, Angioprevention’: angiogenesis is a common and key target for cancer chemopreventive agents, FASEB J. 16:2–14.
  1041. Toze, S., 1999, PCR and the detection of microbial pathogens in water and wastewater, Wat. Res. 33:3545–3556.
  1042. Tracey, K. J., 2002, The inflammatory reflex, Nature 420:853–859.
  1043. Traverso, N., Menini, S., Odetti, P., Pronzato, M. A., Cottalasso, D., and Marinari, U. M., 2002, Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver, Free Radic. Biol. Med. 32:350–359.
  1044. Travagli, V., Zanardi, I., and BocciSilvietti, A. V., 2007, A physicochemical investigation on the effects of ozone on blood, Intern. J. Biolog. Macromol. 41:504–511.
  1045. Travagli, V., Zanardi, I., Gabbrielli, A., Paccagnini, E., and Bocci, V., 2009a, Artif. Organs, October 10 PMID 19817737.
  1046. Travagli, V., Zanardi, I., and Bocci, V., 2009b, Topical applications of ozone and ozonated oils as anti-infective agents: an insight into the patent claims, Recent Pat. Antiinfect. Drug Discov. 4:130–142.
  1047. Travagli, V., Zanardi, I., Bernini, P. et al., 2010, Effects of ozone blood treatment on the metabolite profile of human blood, Intern. J. Toxicol. in press.
  1048. Travagli, V., Zanardi, I., Gabbrielli, A., Paccagnini, E., Bocci, V., 2010a, Are dialysis devices usable as ozone gas exchangers? Artif Organs 34(2):170–175. doi: 10.1111/j.15251594.2009.00767.x.
  1049. Travagli, V., Zanardi, I., Bernini, P., et al., 2010b, Effects of ozone blood treatment on the metabolite profile of human blood. Int. J. Toxicol. 29:165–174.
  1050. Travagli, V., Zanardi, I., Valacchi, G., Bocci, V., 2010c, Ozone and ozonated oils in skin diseases: a review. Mediat. Inflamm. doi: 10.1155/2010/610418.
  1051. Trippel, S. B., 1995, Growth factor actions on articular cartilage, J. Rheumatol. 43:129–132.
  1052. Tse, H. F., Kwong, Y. L., Chan, J. K., Lo, G., Ho, C. L., and Lau, C. P., 2003, Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation, Lancet 361:47–49.
  1053. Tylicki, L., Biedunkiewicz, B., Nieweglowski, T., Chamienia, A., Slizien, A. D., Luty, J., LysiakSzydlowska, W., and Rutkowski, B., 2004a, Ozonated autohemotherapy in patients on maintenance hemodialysis: influence on lipid profile and endothelium, Artif. Organs 28:234–237.
  1054. Tylicki, L., Biedunkiewcz, B., Rachon, D. et al., 2004b, No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients, Mediators Inflamm. 13:377–380.
  1055. Tylicki, L., Niew, G. T., Biedunkiewicz, B., Burakowski, S., and Rutkowski, B., 2001, Beneficial clinical effects of ozonated autohemotherapy in chronically dialysed patients with atherosclerotic ischemia of the lower limbs – pilot study, Int. J. Artif. Organs 24:79–82.
  1056. Tylicki, L., Nieweglowski, T., Biedunkiewicz, B., Chamienia, A., Debska-Slizien, A., Aleksandrowicz, E., Lysiak-Szydlowska, W., and Rutkowski, B., 2003, The influence of ozonated autohemotherapy on oxidative stress in hemodialyzed patients with atherosclerotic ischemia of lower limbs, Int. J. Artif. Organs 26:297–303.
  1057. Ueno, I., Hoshino, M., Miura, T., and Shinriki, N., 1998, Ozone exposure generates free radicals in the blood samples in vitro. Detection by the ESR spin-trapping technique, Free Radic. Res. 29:127–135.
  1058. Unger, R. H., 2002, Lipotoxic diseases, Annu. Rev. Med. 53:319–336.
  1059. Urschel, H. C., 1967, Cardiovascular effects of hydrogen peroxide: current status, Dis. Chest 51:180–192.
  1060. Valacchi, G., and Bocci, V., 1999, Studies on the biological effects of ozone: 10. Release of factors from ozonated human platelets, Mediators Inflamm. 8:205–209.
  1061. Valacchi, G., and Bocci, V., 2000, Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells, Mediators Inflamm. 9:271–276. Valacchi, G., Fortino, V., Bocci, V., 2005, The dual action of ozone on the skin. Br. J. Dermatol. 153:1096–1100.
  1062. Valacchi, G., Pagnin, E., Okamoto, T., Corbacho, A. M., Olano, E., Davis, P. A., van der Vliet, A., Packer, L., and Cross, C. E., 2003, Induction of stress proteins and MMP-9 by 0.8 ppm of ozone in murine skin, Biochem. Biophys. Res. Commun. 305:741–746.
  1063. Valacchi, G., van der Vliet, A., Schock, B. C., Okamoto, T., Obermuller-Jevic, U., Cross, C. E., and Packer, L., 2002, Ozone exposure activates oxidative stress responses in murine skin, Toxicology 179:163–170.
  1064. Valacchi, G., Weber, S. U., Luu, C., Cross, C. E., and Packer, L., 2000, Ozone potentiates vitamin E depletion by ultraviolet radiation in the murine stratum corneum, FEBS Lett. 466: 165– 168.
  1065. Valdagni, R., and Amichetti, M., 1994, Report of long-term follow-up in a randomized trial comparing radiation therapy and radiation therapy plus hyperthermia to metastatic lymph nodes in stage IV head and neck patients, Int. J. Radiat. Oncol. Biol. Phys. 28:163–169.
  1066. Valeri, C. R., Contreas, T. J., Feingold, H., Shebley, R. H., and Jaeger, R. J., 1973, Accumulation of di-2-ethylhexyl phthalate (DEHP) in whole blood, platelet concentrates and platelet-poor plasma. I: effect of DEHP on platelet survival and function, Environ. Health Perspect. 3: 103–118.
  1067. Van der Zee, J., van Beek, E., Dubbelman, T. M. A. R., and Van Steveninck, J., 1987, Toxic effects of ozone on murine L929 fibroblasts, Biochem. J. 247:69–72.
  1068. Van Leeuwen, R., Vingerling, J. R., Hofman, A., de Jong, P. T., and Stricker, B. H., 2003, Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement, BMJ 326:255–256.
  1069. Van Parijs, L., and Abbas, A. K., 1998, Homeostasis and self-tolerance in the immune system: turning lymphocytes off, Science 280:243–248.
  1070. Varro, J., 1966, Über das Krebsproblem und seine Therapie, Ztschr, Int. Med. Ges. F. Blut. U. Geschwulstkrankheiten 4:5–6.
  1071. Varro, J., 1974, Die krebsbehandlung mit ozon, Erfahrungsheilkunde 23:178–181.
  1072. Varro, J., 1983, Ozone applications in cancer cases, in Medical Applications of Ozone (J. LaRaus, Ed.), International Ozone Association, Pan American Committee, Norwalk, CT, pp. 94– 95.
  1073. Vasiliou, V., Pappa, A., and Petersen, D. R., 2000, Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism, Chem. Biol. Interact. 129:1–19.
  1074. Vaughn, J. M., Chen, Y. S., Novotny, J. F., and Strout, D., 1990, Effects of ozone treatment on the infectivity of hepatitis A virus, Can. J. Microbiol. 36:557–560.
  1075. Vaupel, P., and Hockel, M., 2000, Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance, Int. J. Oncol. 17:869–879.
  1076. Verga, C., 1989, Nuovo approccio terapeutico alle ernie e protrusioni discali lombari, Riv. Neuroradiol. 2:148.
  1077. Verma, A., Hirsch, D. J., Glatt, C. E., Ronnett, G. V., and Snyder, S. H., 1993, Carbon monoxide: a putative neural messenger, Science 259:381–384.
  1078. Verrax, J., and Calderon, P. B., 2009, Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects, Free Radic. Biol. Med. 47:32–40.
  1079. Verrazzo, G., Coppola, L., Luongo, C., Sammartino, A., Giunta, R., Grassia, A., Ragone, R., and Tirelli, A., 1995, Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease, Undersea Hyperbar. Med. 22: 17–22.
  1080. Verteporfin in Photodynamic Therapy (VIP) Study Group, 2003, Verteporfin therapy of subfoveal choroidal neovascularization in pathologic myopia: 2-year results of a randomized clinical trial – VIP report no. 3, Ophthalmology 110:667–673.
  1081. Victor, V. M., McCreath, K. J., and Rocha, M., 2006, Recent progress in pharmacological research of antioxidants in pathological conditions, cardiovascular health, Recent Pat. Antinfect. Drug Discov. 1:17–31.
  1082. Victorin, K., 1992, Review of the genotoxicity of ozone, Mutat. Res. 277:221–238.
  1083. Videm, V., Mollnes, T. E., Bergh, K., Fosse, E., Mohr, B., Hagve, T. A., Aasen, A. O., and Svennevig, J. L., 1999, Heparin-coated cardiopulmonary bypass equipment. II. Mechanisms for reduced complement activation in vivo, J. Thorac. Cardiovasc. Surg. 117:803–809.
  1084. Viebahn-Hänsler, R., 1999a, The use of ozone in medicine, ODREI Publishers, Iffezheim, pp. 1–148.
  1085. Viebahn-Hänsler, R., 1999b, Einfluss auf den erythrozytenstoffwechsel, in Ozon-Handbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. 1–15.
  1086. Viebahn-Hänsler, R., Lell, B., and Kremsner, P. G., 2001, The effect of ozone on plasmodium falciparum-infected red blood cells, in Proceedings of the 15th Ozone World Congress, London, UK, 11th–15th September 2001, Medical Therapy Conference (IOA 2001, Ed.), Speedprint MacMedia Ltd, Ealing, London, UK, pp. 26–39.
  1087. Vingerling, J. R., Hofman, A., Grobbee, D. E., and de Jong, P. T., 1996, Age-related macular degeneration and smoking. The Rotterdam Study, Arch. Ophthalmol. 114:1193–1196.
  1088. Viru, A., and Tendzegolskis, Z., 1995, Plasma endorphin species during dynamic exercise in humans, Clin. Physiol. 15:73–79.
  1089. Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., and Topol, E. J., 2003, Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials, Lancet 361:2017–2023.
  1090. Vollmer, T., Key, L., Durkalski, V., Tyor, W., Corboy, J., Markovic-Plese, S., Preiningerova, J., Rizzo, M., and Singh, I., 2004, Oral simvastatin treatment in relapsing-remitting multiple sclerosis, Lancet 363:1607–1608.
  1091. Von Harsdorf, R., Poole-Wilson, P. A., and Dietz, R., 2004, Regenerative capacity of the myocardium: implications for treatment of heart failure, Lancet 363:1306–1313.
  1092. Wadhwa, P. D., Zielske, S. P., Roth, J. C., Ballas, C. B., Bowman, J. E., and Gerson, S. L., 2002, Cancer gene therapy: scientific basis, Annu. Rev. Med. 53:437–452.
  1093. Wagner, M., Cadetg, P., Ruf, R., Mazzucchelli, L., Ferrari, P., and Redaelli, C. A., 2003, Heme oxygenase-1 attenuates ischemia/reperfusion-induced apoptosis and improves survival in rat renal allografts, Kidney Int. 63:1564–1573.
  1094. Wahl, C., Liptay, S., Adler, G., and Schmid, R. M., 1998, Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B, J. Clin. Invest. 101:1163–1174.
  1095. Wang, P., Chen, H., Qin, H., Sankarapandi, S., Becher, M. W., Wong, P. C., and Zweier, J. L., 1998, Overexpression of human copper, zinc-superoxide dismutase (SOD1) prevents postischemic injury, Proc. Natl. Acad. Sci. USA 95:4556–4560.
  1096. Warkentin, T. E., 2003, Heparin-induced thrombocytopenia: pathogenesis and management, Br. J. Haematol. 121:535–555.
  1097. Warlow, C., Sudlow, C., Dennis, M., Wardlaw, J., and Sandercock, P., 2003, Stroke, Lancet 362:1211–1224.
  1098. Warren, H. S., Suffredini, A. F., Eichacker, P. Q., and Munford, R. S., 2002, Risks and benefits of activated protein C treatment for severe sepsis, N. Engl. J. Med. 347:1027–1030.
  1099. Warren, J. B., and Higenbottam, T., 1996, Caution with use of inhaled nitric oxide, Lancet 348:629–630.
  1100. Wasser, G. H., 1995a, Behandlung von Verletzungen mit ozoniertem Wasser, in OzonHandbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. V-7.4 1–V-7.4 8.
  1101. Wasser, G. H., 1995b, Zerebrale Durchblutungsstörungen, in Ozon-Handbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, pp. V6.3 1–V-6.3 12.
  1102. Weber, W., and Butcher, J., 2001, Doubts over cell therapy for Parkinson’s disease, Lancet 357:859.
  1103. Webster, G. J., Hallett, R., Whalley, S. A., Meltzer, M., Balogun, K., Brown, D., Farrington, C. P., Sharma, S., Hamilton, G., Farrow, S. C., Ramsay, M. E., Teo, C. G., and Dusheiko, G. M., 2000, Molecular epidemiology of a large outbreak of hepatitis B linked to autohaemotherapy, Lancet 356:379–384.
  1104. Weck, P. K., Buddin, D. A., and Whisnant, J. K., 1988, Interferons in the treatment of genital human papillomavirus infections, Am. J. Med. 85:159–164.
  1105. Wehrli, F., and Steinbart, H., 1954, Erfahrungen mit der Haematogenen Oxydations – Therapie (HOT), Ars. Medici. 10:44–51.
  1106. Wei, Y., Chen, K., Whaley-Connell, A. T., Stump, C. S. et al., 2008, Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species, Am. J. Physiol. Regul. Integr. Comp. Physiol. 294:R673–R680.
  1107. Weksler, M. E., Pawelec, G., and Franceschi, C., 2009, Immune therapy for age-related diseases, Trends Immunol. 30:344–350.
  1108. Weleber, R. G., 1996, The Cuban experience. False hope for a cure for retinitis pigmentosa, Arch. Ophthalmol. 114:606–607.
  1109. Wells, K. H., Latino, J., Gavalchin, J., and Poiesz, B. J., 1991, Inactivation of human immunodeficiency virus type 1 by ozone in vitro, Blood 78:1882–1890.
  1110. Wenning, W., Haghikia, A., Laubenberger, J. et al., 2009, Treatment of progressive multifocal leukoencephalopathy associated with natalizumab, N. Engl. J. Med., 361:1075–1080.
  1111. Wenzel, R. P., and Edmond, M. B., 1999, The evolving technology of venous access, N. Engl. J. Med. 340:48–50.
  1112. Wenzel, R. P., and Edmond, M. B., 2001, The impact of hospital-acquired bloodstream infections, Emerg. Infect. Dis. 7:174–177.
  1113. Werkmeister, H., 1995, Dekubitalgeschwüre und die Behandlung mit der OzonUnterdruckbegasung, in Ozon-Handbuch. Grundlagen. Prävention. Therapie (E. G. Beck, and R. Viebahn-Hänsler, Eds.), Ecomed, Landsberg, p. V-7.1 1–V-7.1 22.
  1114. Wessely, S., 2001, Chronic fatigue: symptom and syndrome, Ann. Intern. Med. 134:838–843.
  1115. West, I. C., 2000, Radicals and oxidative stress in diabetes, Diabet. Med. 17:171–180.
  1116. West, S., Vitale, S., Hallfrisch, J., Munoz, B., Muller, D., Bressler, S., and Bressler, N. M., 1994, Are antioxidants or supplements protective for age related macular degeneration? Arch. Ophthalmol. 112:222–227.
  1117. Westendorp, M. O., Shatrov, V. A., Schulze-Osthoff, K., Frank, R., Kraft, M., Los, M., Krammer,
  1118. P. H., Droge, W., and Lehmann, V., 1995, HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state, EMBO J. 14:546–554.
  1119. Whysner, J., Conaway, C. C., Verna, L., and Williams, G. M., 1996, Vinyl chloride mechanistic data and risk assessment: DNA reactivity and cross-species quantitative risk extrapolation, Pharmacol. Ther. 71:7–28.
  1120. Wieczorek, G., Asemissen, A., Model, F. et al., 2009, Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue, Cancer Res. 69:599–608.
  1121. Wiernsperger, N. F., 2003, Oxidative stress as a therapeutic target in diabetes: revisiting the controversy, Diabetes Metab. 29:579–585.
  1122. Wigley, F. M., Wise, R. A., Seibold, J. R., McCloskey, D. A., Kujala, G., Medsger, T. A., Jr., Steen, V. D., Varga, J., Jimenez, S., and Mayes, M., 1994, Intravenous iloprost infusion in patients with Raynaud phenomenon secondary to systemic sclerosis. A multicenter, placebocontrolled, double-blind study, Ann. Intern. Med. 120:199–206.
  1123. Williams, H., 2002, New treatments for atopic dermatitis, BMJ 324:1533–1534.
  1124. Williamson, L. M., 2000, Leucocyte depletion of the blood supply – how will patients benefit? Br. J. Haematol. 110:256–272.
  1125. Willis, W. D. J., 1995, Il sistema somatosensoriale, in Fisiologia (R. M. Berne, and M. N. Levy, Eds.), Casa Editrice Ambrosiana, Milano, pp. 130–151.
  1126. Wilson, P. W., and Grundy, S. M., 2003a, The metabolic syndrome: practical guide to origins and treatment: part I, Circulation 108:1422–1424.
  1127. Wilson, P. W., and Grundy, S. M., 2003b, The metabolic syndrome: a practical guide to origins and treatment: part II, Circulation 108:1537–1540.
  1128. Wing, K., and Sakaguchi, S., 2010, Regulatory T cells exert checks and balances on self tolerance and autoimmunity, Nat. Immunol. Jan. 11(1):7–13.
  1129. Wiseman, H., and Halliwell, B., 1996, Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer, Biochem. J. 313:17–29.
  1130. Witko-Sarsat, V., Friedlander, M., Nguyen, K. T., Capeillere-Blandin, C., Nguyen, A. T., Canteloup, S., Dayer, J. M., Jungers, P., Drueke, T., and Descamps-Latscha, B., 1998, Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure, J. Immunol. 161:2524–2532.
  1131. Witko-Sarsat, V., Rieu, P., Descamps-Latscha, B., Lesavre, P., and Halbwachs-Mecarelli, L., 2000, Neutrophils: molecules, functions and pathophysiological aspects, Lab. Invest. 80:617– 653.
  1132. Witschi, H., Espiritu, I., Pinkerton, K. E., Murphy, K., and Maronpot, R. R., 1999, Ozone carcinogenesis revisited, Toxicol. Sci. 52:162–167.
  1133. Wolff, H. H., 1974, Die Behandlung peripherer Durchblutungsstörungen mit Ozon, Erfahr. Hk. 23:181–184.
  1134. Wolff, H. H., 1979, Das medizinische Ozon. Theoretische Grundlagen, Therapeutische Anwendungen, Verlag für Medizin, Heidelberg.
  1135. Wolff, S., 1996, Aspects of the adaptive response to very low doses of radiation and other agents, Mutat. Res. 358:135–142.
  1136. Wood, K. C., Hsu, L. L., Gladwin, M. T., 2008, Sickle cell disease vasculopathy: a state of nitric oxide resistance. Free Radic. Biol. Med. 44:1506–1528.
  1137. Wood, M. J., Johnson, R. W., McKendrick, M. W., Taylor, J., Mandal, B. K., and Crooks, J., 1994, A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster, N. Engl. J. Med. 330:896–900.
  1138. Xu, R. X., 2004, Burns regenerative medicine and therapy, Karger Publishers, Basel.
  1139. Yakes, F. M., and Van Houten, B., 1997, Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress, Proc. Natl. Acad. Sci. USA 94:514–519.
  1140. Yamamoto, H., Yamamoto, Y., Yamagami, K., Kume, M., Kimoto, S., Toyokuni, S., Uchida, K., Fukumoto, M., and Yamaoka, Y., 2000, Heat-shock preconditioning reduces oxidative protein denaturation and ameliorates liver injury by carbon tetrachloride in rats, Res. Exp. Med. (Berl) 199:309–318.
  1141. Yamamoto, Y., 2000, Fate of lipid hydroperoxides in blood plasma, Free Radic. Res. 33:795– 800.
  1142. Yang, J. C., Haworth, L., Sherry, R. M., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Steinberg, S. M., Chen, H. X., and Rosenberg, S. A., 2003, A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer, N. Engl. J. Med. 349:427–434.
  1143. Yee Koh, M., Spivak-Kroizman, T. R., Powis, G., 2008, HIF-1 regulation: not so easy come,easy go. Trends Biochem. Sci. 33:526–534.
  1144. Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., and Mizuno, Y., 1996, Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease, Proc. Natl. Acad. Sci. USA 93:2696–2701.
  1145. Young, S. D., Marshall, R. S., and Hill, R. P., 1988, Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells, Proc. Natl. Acad. Sci. USA 85:9533–9537.
  1146. Youngman, L. D., Park, J. Y., and Ames, B. N., 1992, Protein oxidation associated with aging is reduced by dietary restriction of protein or calories, Proc. Natl. Acad. Sci. USA 89:9112–9116.
  1147. Yu, B. P., 1994, Cellular defenses against damage from reactive oxygen species, Physiol. Rev. 74:139–162.
  1148. Yu, B. P., 1996, Aging and oxidative stress: modulation by dietary restriction, Free Radic. Biol. Med. 21:651–668.
  1149. Zabel, W., 1960, Ganzheitsbehandlung der Geschwulsterkrankungen, Hippokrates 31:751–760.
  1150. Zagury, D., Lachgar, A., Chams, V., Fall, L. S., Bernard, J., Zagury, J. F., Bizzini, B., Gringeri, A., Santagostino, E., Rappaport, J., Feldman, M., Burny, A., and Gallo, R. C., 1998, Interferon alpha and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS, Proc. Natl. Acad. Sci. USA 95:3851–3856.
  1151. Zajicek, G., 1995, The placebo effect is the healing force of nature, Cancer J. 8:44–45.
  1152. Zamora, Z., Gonzales, R., Guanche, D., 2008, Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa. Inflamm. Res. 57:39–43.
  1153. Zanardi, I., Travagli, V., Gabbrielli, A., Chiasserini, L., and Bocci, V., 2008, Physico-chemical characteruzation of sesame oil derivatives, Lipids 43:877–886.
  1154. Zeuzem, S., 2004, Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: who responds less well? Ann. Intern. Med. 140:370–381.
  1155. Zhang, Y., and Hogg, N., 2004, S-nitrosohemoglobin: a biochemical perspective, Free Radic. Biol. Med. 36:947–958.
  1156. Zhong, H., De Marzo, A. M., Laughner, E., Lim, M., Hilton, D. A., Zagzag, D., Buechler, P., Isaacs, W. B., Semenza, G. L., and Simons, J. W., 1999, Overexpression of hypoxiainducible factor 1alpha in common human cancers and their metastases, Cancer Res. 59: 5830–5835.
  1157. Zhulina, N. I. et al. 1993, Ozonetherapy efficiency in the treatment of patients with atherosclerosis of coronary and cerebral vessels, in Ozone in Medicine, in Proceedings of the 11th Ozone World Congress (P. A. C. International Ozone Association, Ed.), Stamford, CT, pp. M-2-9-11.
  1158. Zino, S., Skeaff, M., Williams, S., and Mann, J., 1997, Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants, BMJ 314:1787–1791.
  1159. Zoukourian, C., Wautier, M. P., Chappey, O., Dosquet, C., Rohban, T., Schmidt, A. M., Stern, D., and Wautier, J. L., 1996, Endothelial cell dysfunction secondary to the adhesion of diabetic erythrocytes. Modulation by iloprost, Int. Angiol. 15:195–200.
  1160. Zucker et al., 2014, Nrf2 Amplifies Oxidative Stress via Induction of Klf9, Molecular Cell, Vol 53, Issue 6, p916–928, 20
  1161. Zuckerbraun, B. S., and Billiar, T. R., 2003, Heme oxygenase-1: a cellular Hercules, Hepatology 37:742–744.
    Cerrar